Pediatric Pulmonary Vascular Disease

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial

Christine M. Pierce, Min H. Zhang, Baldvin Jonsson, Dinu Iorga, Narayan Cheruvu, Cecile C. Balagtas, Robin H. SteinhornGreat Ormond Street Hospital for Children. Pfizer Inc. Karolinska Institute and University Hospital. Rady Children’s Hospital and University of California San Diego.United States Journal of PediatricsJ Pediatr 2021; 237: 154-161DOI: 10.1016/j.jpeds.2021.05.051 AbstractObjective: To investigate the efficacy and safety of sildenafil […]

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial Read More »

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC

Wanjie Huang, Na Liu, Xin Tong, Yanna DuShengjing Hospital of China Medical University. The First Affiliated Hospital of Zhengzhou University.China International Journal of Molecular MedicineInt J Mol Med 2022; 49: DOI: 10.3892/ijmm.2021.5074 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC Read More »

Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations

Alexandra Heath-Freudenthal, Lilian Toledo-Jaldin, Inge von Alvensleben, Litzi Lazo Vega, Rodrigo Mizutani, Margaret Stalker, Hussna Yasini, Fanny Mendizabal, Jesus Dorado Madera, William Mundo, Melany Castro-Monrroy, Julie A. Houck, Any Moreno-Aramayo, Valquiria Miranda-Garrido, Emily J. Su, Dino A. Giussani, Steven H. Abman, Lorna G. Moore, Colleen G. JulianKardiozentrum. Hospital Materno-Infantil. University of Colorado. Universidad Mayor de San Andrés. University of Cambridge.Bolivia, United States and United Kingdom HypertensionHypertension 2022; 79: 1286-1296DOI: 10.1161/HYPERTENSIONAHA.122.19078 AbstractBackground: Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring and occur

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Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension

Shinichi Takatsuki, Tomotaka Nakayama, Yurika Shimizu, Reiko Kawai, Hiroyuki MatsuuraToho University Omori Medical Center. Kochi Medical School Hospital.Japan Cardiology in the YoungCardiol Young 2023; 33: 196-200DOI: 10.1017/S1047951122000415 AbstractObjective: This study aimed to investigate the safety, tolerability, and efficacy of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.Methods: This retrospective cohort study included clinical

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Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea

Melissa A. Maloney, Sally L. Davidson, Ramon A. Durazo-Arvizu, Jacqueline M. Breunig, Daniel U. Okpara, Emily S. GillettChildren’s Hospital Los Angeles and University of Southern California Keck School of Medicine.United States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2022; 18: 1629-1637DOI: 10.5664/jcsm.9944 AbstractStudy objectives: Pulmonary hypertension (PH) is a rare yet serious complication of obstructive sleep

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Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy

Regan E. Geisinger, Amy H. Stanford, Brady Thomas, Steven H. Abman, Patrick J. McNammaraUniversity of Iowa. University of Colorado.United States Journal of PediatricsJ Pediatr 2022; DOI: 10.1016/j.jpeds.2022.11.026 AbstractThe effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10),

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Riociguat in children with pulmonary arterial hypertension: The PATENT-CHILD study

Humberto García Aguilar, Matthias Gorenflo, D. Dunbar Ivy, Shahin Moledina, Biagio Castaldi, Hidekazu Ishida, Paweł Cześniewicz, Jacek Kusa, Oliver Miera, Joseph Pattathu, Ken‐Pen Weng, Laszlo Ablonczy, Christian Apitz, Marta Katona, Kenichi Kurosaki, Tomas Pulido, Hiroyuki Yamagishi, Kazushi Yasuda, Galia Cisternas, Melanie Goth, Susanne Lippert, Anna Radomskyj, Soundos Saleh, Stefan Willmann, Gabriela Wirsching, Damien Bonnet, Maurice

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High-Altitude Pulmonary Edema in Colorado Children: A Cross-Sectional Survey and Retrospective Review

Timothy D. Kelly, Maxene Meier, Jason P. Weinman, Dunbar Ivy, John T. Brinton, Deborah R. LiptzinIndiana University. University of Colorado and Children’s Hospital Colorado. Colorado School of Public Health.United States High Altitude Medicine and BiologyHigh Alt Med Biol 2022; 23: 119-124DOI: 10.1089/ham.2021.0121 AbstractIntroduction: Few studies of high-altitude pulmonary edema (HAPE) are specific to the pediatric population. The

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Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics

Florian Kipfmueller, Lukas Schroeder, Ulrich Gembruch, Suemeyra Akkas, Flaminia Pugnaloni, Bartolomeo Bo, Lotte Lemloh, Annegret Geipel, Christoph Berg, Andreas Heydweiller, Andreas MuellerUniversity of Bonn. Ospidale Bambinu Gesu. University Hospital Cologne.Germany and Italy Journal of Clinical MedicineJ Clin Med 2022; 11: DOI: 10.3390/jcm11113038 AbstractBackground: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia

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Clinical Significance of Early Pulmonary Hypertension in Preterm Infants

Sanne Arjaans, Marian W. F. Fries, Mirthe H. Schoots, Carine F. M. Schilte, Marc T. R. Roofthooft, Elianne J. L. E. Vrijlandt, Arie F. Bos, Elisabeth M. W. Kooi, Rolf M. F. BergerUniversity of Groningen, Beatrix Children’s Hospital and University Medical Center Groningen.Netherlands Journal of PediatricsJ Pediatr 2022; 251: 74-81DOI: 10.1016/j.jpeds.2022.07.039 AbstractObjective: To characterize different phenotypes of

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