Pediatric Pulmonary Vascular Disease

An electrocardiographic score to predict pulmonary hypertension in children with atrial septal defect

Indah K Murni, Taichi Kato, Muhammad Taufik Wirawan, Nadya Arafuri, Kristia Hermawan, Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Sasmito Nugroho, Noormanto Noormanto, Noriaki Emoto, Lucia Kris DinartiUniversitas Gadjah Mada and Dr. Sardjito Hospital. Nagoya University Graduate School of Medicine. Kobe University Graduate School of Medicine. Kobe Pharmaceutical University.Indonesia and Japan BioMed Central PediatricsBMC Pediatr 2023;

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Pulmonary vascular disease as a complication of pediatric congenital heart diseases

Julie Wacker, Raphael Joye, Leon Genecand, Frederic Lador, Maurice BeghettiGeneva University Hospitals. Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pédiatrique.Switzerland Translational PediatricsTransl Pediatr 2023; 12: 1041-1052DOI: 10.21037/tp-23-64 AbstractCongenital and acquired heart diseases can cause pulmonary hypertension (PH) in children, either by increasing pulmonary blood flow (PBF), left atrial pressure (LAp), and/or pulmonary vascular resistance (PVR).

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Cardiopulmonary Phenotypes and Protein Signatures in Children With Down Syndrome

Emily M. DeBoer, Kristine Wolter-Warmerdam, Robin R. Deterding, Juana Marmolejo, Tom Blumenthal, Joaquin M. Espinosa, Francis Hickey, Brandie D. WagnerUniversity of Colorado School of Medicine. United States Clinical PediatricsClin Pediatr 2023; DOI: 10.1177/00099228231179453 AbstractPulmonary disease, lower respiratory tract infection, and pneumonia are the largest causes of morbidity and mortality in individuals with Down syndrome (DS), but

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The role of rhIGF-1/BP3 in the prevention of pulmonary hypertension in bronchopulmonary dysplasia and its underlying mechanism

Sehua Qu, Lianqiang Shan, Xin Chen, Zhen Zhang, Yumeng Wu, Yun Chen, Feixiang Zhuo, Yitong Wang, Huaifu DongThe First Affiliated Hospital of Bengbu Medical College. China BioMed Central Pulmonary MedicineBMC Pulm Med 2023; 23: DOI: 10.1186/s12890-023-02498-1 AbstractBackground: This study aimed to determine whether postnatal treatment with recombinant human IGF-1 (rhIGF-1)/binding peptide 3 (BP3) ameliorates lung injury and

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Quantitative Measures of Right Ventricular Size and Function by Echocardiogram Correlate with Cardiac Catheterization Hemodynamics in Congenital Diaphragmatic Hernia

Catherine M. Avitabile, Sabrina Flohr, Leny Mathew, Yan Wang, Devon Ash, David B. Frank, Jennifer E. Tingo, Natalie E. Rintoul, Holly L. HedrickUniversity of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Journal of PediatricsJ Pediatr 2023; 261DOI: 10.1016/j.jpeds.2023.113564 AbstractObjective: To evaluate associations between cardiac catheterization (cath) hemodynamics, quantitative measures of right ventricular

Quantitative Measures of Right Ventricular Size and Function by Echocardiogram Correlate with Cardiac Catheterization Hemodynamics in Congenital Diaphragmatic Hernia Read More »

Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia

Jason O. Robertson, Peter Bazeley, Serpil C. Erzurum, Kewal AsosinghCleveland Clinic.United States Scientific ReportsSci Rep 2023; 13DOI: 10.1038/s41598-023-37050-y AbstractCongenital diaphragmatic hernia (CDH) is a neonatal anomaly that includes pulmonary hypoplasia and hypertension. We hypothesized that microvascular endothelial cell (EC) heterogeneity is different in CDH lungs and related to lung underdevelopment and remodeling. To test this, we

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Evaluation of Postnatal Complications in Clinical and Histological Chorioamnionitis in Extremely Preterm Infants: A Japanese Cohort Study

Shuji Ishida, Hidehiko Nakanishi, Rika Sekiya, Kohei Kawada, Yukako Kosaka, Ayano Yamaguchi, Mari Ooka, On befalf of the Neonatal Research Network of JapanKitasato University.Japan American Journal of PerinatologyAm J Perinatol 2023; DOI: 10.1055/a-2113-4332 AbstractObjective: Terminating pregnancy appropriately before the intrauterine infection has progressed may have an improved prognosis for preterm infants. We evaluate how the combination of histological chorioamnionitis (hCAM) and clinical chorioamnionitis

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Dynamics of pulmonary hypertension severity in the first 48 h in neonates with prenatally diagnosed congenital diaphragmatic hernia

Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn.  Royal Hospital for Children.Germany and United Kingdom Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1164473 AbstractIntroduction: Pulmonary hypertension (PH) is one of the major contributing factors to the high morbidity and mortality in neonates with congenital

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Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia

Krithika Lingappan, Oluyinka O. Olutoye II, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. KeswaniChildren’s Hospital of Philadelphia. Baylor College of Medicine and Texas Children’s Hospital. University of Delaware. United States American Journal of Physiology Lung Cellular and

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Case report: Central venous catheter thrombosis complicated by chronic thromboembolic disease/pulmonary hypertension in two children requiring parenteral nutrition

Maja Hanuna, Joseph Pattathu, Joscha Buech, Christine Kamla, Nikolaus Kneidinger, Juergen Behr, Katrin Milger, Tobias Veit, Marina Nagel, Jan Abicht, Robert Dalla-Pozza, Marcus Fischer, Andre Jakob, Matthias Hermann, Rene Schramm, Laura L. Rosenthal, Nikolaus Haas, Jürgen Hörer, Christian Hagl, Sebastian G. MichelLudwig Maximilian University Munich. Munich Heart Alliance. Comprehensive Pneumology Center Munich. Heart and Diabetes

Case report: Central venous catheter thrombosis complicated by chronic thromboembolic disease/pulmonary hypertension in two children requiring parenteral nutrition Read More »

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