Pediatric Pulmonary Vascular Disease

Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension

Michal Schäfer, Benjamin S. Frank, D. Dunbar Ivy, Max B. Mitchell, Kathryn K. Collins, Pei-Ni Jone, Johannes C. von AlvenslebenUniversity of Colorado and Children’s Hospital Colorado.United States Journal of the American Heart AssociationJ Am Heart Assoc 2022; 11: DOI: 10.1161/JAHA.121.024787 AbstractBackground: Electromechanical dyssynchrony is a well described comorbidity in pulmonary arterial hypertension (PAH). ECG-derived measurements reflective […]

Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension Read More »

Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Danielle S. Roberts, Laura G. Sherlock, Janelle N. Posey, Jamie L. Archambault, Eva S. Nozik, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus.United States Physiological ReportsPhysiol Rep 2022; 10: DOI: 10.14814/phy2.15482 AbstractSerotonin (5-hydroxytryptamine, 5-HT) is a potent pulmonary vasoconstrictor and contributes to high pulmonary vascular resistance in the developing ovine lung. In experimental pulmonary hypertension (PH), pulmonary expression of tryptophan hydroxylase-1 (TPH1),

Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension Read More »

Association between pulmonary vein stenosis and necrotizing enterocolitis or gastrointestinal pathology: A case-control study

Jennifer Duchon, Christiana Farkouh‑Karoleski, Dominique D. Bailey, Usha S. KrishnanBronx Care Hospital System. Columbia University Irving Medical Center. Valley Health System. United States Annals of Pediatric CardiologyAnn Pediatr Cardiol 2022; 15: 13-19DOI: 10.4103/apc.apc_210_21 AbstractObjective: Pulmonary vein stenosis (PVS) is an emerging cause of pulmonary hypertension in preterm infants. It is an often lethal condition with poor long.term

Association between pulmonary vein stenosis and necrotizing enterocolitis or gastrointestinal pathology: A case-control study Read More »

Pulmonary Hypertension in Preterm Infants Treated With Laser vs Anti-Vascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity

Christopher R. Nitkin, Nicholas A. Bamat, Joanne Lagatta, Sara B. DeMauro, Henry C. Lee, Ravi Mangal Patel, Brian King, Jonathan L. Slaughter, J. Peter Campbell, Troy Richardson, Tamorah LewisUniversity of Missouri Kansas City School and Children’s Mercy Hospital. University of Pennsylvania and Children’s Hospital of Philadelphia. Medical College of Wisconsin. Stanford University. Emory University and

Pulmonary Hypertension in Preterm Infants Treated With Laser vs Anti-Vascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity Read More »

Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study

Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep HarigopalNewcastle University and Royal Victoria Infirmary. United Kingdom Archives of Disease in Childhood. Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2022; 107: 13-19DOI: 10.1136/archdischild-2021-322001 AbstractObjectives: To assess the minimum incidence of life-threatening bronchopulmonary dysplasia (BPD), defined as need for positive pressure respiratory support or pulmonary vasodilators

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Pulmonary artery acceleration time in young children is determined by heart rate and transpulmonary gradient but not by pulmonary blood flow: A simultaneous echocardiography-cardiac catheterization study

Christiana Tai, Anyir Hsieh, Anita J. Moon-Grady, Roberta L. Keller, David Teitel, Hythem M. NawaytouUniversity of California, San FranciscoUnited States EchocardiographyEchocardiography 2022; 39: 895-905DOI: 10.1111/echo.15397 AbstractIntroduction: Pulmonary artery acceleration time (PAAT) is considered useful for the non-invasive evaluation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR). PAAT is dependent on PAP, PVR, pulmonary artery compliance,

Pulmonary artery acceleration time in young children is determined by heart rate and transpulmonary gradient but not by pulmonary blood flow: A simultaneous echocardiography-cardiac catheterization study Read More »

Upregulated TSP1 and CD47 Expression in the Lung in Nitrofen-induced Congenital Diaphragmatic Hernia

Hajime TakayasuKitasato University. University of Tsukuba.Japan Pediatrics InternationalPediatr Int 2022; DOI: 10.1111/ped.15447 AbstractBackground: Persistent pulmonary hypertension remains a major cause of mortality and morbidity in congenital diaphragmatic hernia (CDH). The secreted glycoprotein thrombospondin-1 (TSP1), a ligand for receptor CD47, is widely expressed on both systemic and pulmonary vascular cells. TSP1-CD47 signaling has been reported to be one

Upregulated TSP1 and CD47 Expression in the Lung in Nitrofen-induced Congenital Diaphragmatic Hernia Read More »

Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study

Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel GanzevoortUniversity of Amsterdam and Emma Children’s Hospital. University of Groningen, University Medical Center Groningen and Beatrix Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Leiden University Medical Center. Erasmus University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2022; 181: 1709-1718DOI: 10.1007/s00431-021-04355-x AbstractThe aim was

Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study Read More »

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial

Christine M. Pierce, Min H. Zhang, Baldvin Jonsson, Dinu Iorga, Narayan Cheruvu, Cecile C. Balagtas, Robin H. SteinhornGreat Ormond Street Hospital for Children. Pfizer Inc. Karolinska Institute and University Hospital. Rady Children’s Hospital and University of California San Diego.United States Journal of PediatricsJ Pediatr 2021; 237: 154-161DOI: 10.1016/j.jpeds.2021.05.051 AbstractObjective: To investigate the efficacy and safety of sildenafil

Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial Read More »

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC

Wanjie Huang, Na Liu, Xin Tong, Yanna DuShengjing Hospital of China Medical University. The First Affiliated Hospital of Zhengzhou University.China International Journal of Molecular MedicineInt J Mol Med 2022; 49: DOI: 10.3892/ijmm.2021.5074 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC Read More »

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