Pediatric Pulmonary Vascular Disease

Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH)

Ivonne Wieland, Franziska Diekmann, Julia Carlens, Laura Hinze, Katharina Lambeck, Thomas Jack, Georg HansmannHannover Medical School.Germany Frontiers in PediatricsFront Pediat 2022; 10: DOI: 10.3389/fped.2022.1012738 AbstractBackground and objectives: Emerging evidence suggests that increased degradation of von Willebrand factor and decrease in high molecular weight multimers occurs in patients with pulmonary hypertension (PH). However, the link between acquired von […]

Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH) Read More »

DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines

Avante D. Milton, Hanadi Almazrouea, Yi Jina, Gloria Zenderb, Jennifer K. TrittmannaAbigail Wexner Research Institute at Nationwide Children’s Hospital. Ohio State University College of Medicine. United States Journal of Neonatal and Perinatal MedicineJ Neonatal Perinatal Med 2022; 15: 113-121DOI: 10.3233/NPM-210710 AbstractBackground: Bronchopulmonary dysplasia (BPD) is chronic lung disease of prematurity and pulmonary hypertension (PH) is a major

DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines Read More »

Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry

Aravanan Anbu Chakkarapani, Samir Gupta, Asma Jamil, Santosh Kumar Yadav, Nim Subhedar, Helmut D. HummlerSidra Medicine. Weill Cornell Medicine-Qatar. Durham University. Johns Hopkins University School of Medicine. Liverpool Women’s Hospital. University of Tuebingen.Qatar, United Kingdom, United States and Germany European Journal of PediatricsEur J Pediatr 2022; 181: 3915-3922DOI: 10.1007/s00431-022-04602-9 AbstractThis study aims to assess the effects of inhaled nitric oxide (iNO) on oxygenation in the

Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry Read More »

Screening Echocardiography Identifies Risk Factors for Pulmonary Hypertension at Discharge in Premature Infants with Bronchopulmonary Dysplasia

B. A. Madden, M. R. Conaway, S. A. Zanelli, M. A. McCullochAnn and Robert H. Lurie Children’s Hospital of Chicago. University of Virginia and University of Virginia Children’s Hospital.United States Pediatric CardiologyPediatr Cardiol 2022; 43: 1743-1751DOI: 10.1007/s00246-022-02911-2 AbstractHypothesis: Premature infants with bronchopulmonary dysplasia (BPD) are at increased risk of secondary pulmonary hypertension (BPD-PH). Prior studies yielded mixed

Screening Echocardiography Identifies Risk Factors for Pulmonary Hypertension at Discharge in Premature Infants with Bronchopulmonary Dysplasia Read More »

Neonatal outcome comparisons between preterm infants with or without early pulmonary hypertension following prolonged preterm premature rupture of membranes before 25 gestational weeks in Korean Neonatal Network

Ga Young Park, Won Soon Park, MinSun Kim, Myung Hee Lee, Ga Won Jeon, Sung Shin Kim, Yun Sil ChangSoonchunhyang University Bucheon Hospital and Soonchunhyang University School of Medicine. Samsung Medical Center and Sungkyunkwan University School of Medicine. Inje University Busan Paik Hospital and Inje University College of Medicine.Republic of Korea Journal of Maternal Fetal

Neonatal outcome comparisons between preterm infants with or without early pulmonary hypertension following prolonged preterm premature rupture of membranes before 25 gestational weeks in Korean Neonatal Network Read More »

Oxygen Saturation Index in Neonates with a Congenital Diaphragmatic Hernia: A Retrospective Cohort Study

Emily J. J. Horn-Oudshoorn, Marijn J. Vermeulen, Kelly J. Crossley, Suzan C. M. Cochius-den Otter, J. Marco Schnater, Irwin K.M. Reiss, Philip L. J. DeKoninckErasmus MC University Medical Center, Rotterdam. Monash University. Netherlands and Australia NeonatologyNeonatology 2022; 119: 111-118DOI: 10.1159/000520883 AbstractIntroduction: The oxygenation index (OI) is a marker for respiratory disease severity and adverse neonatal outcomes. The

Oxygen Saturation Index in Neonates with a Congenital Diaphragmatic Hernia: A Retrospective Cohort Study Read More »

Pulmonary hypertension screening in children with sickle cell disease

Kok Hoe Chan, Syeda Hiba Rizvi, Wilfredo De Jesus-Rojas, James M. Stark, Ricardo A. Mosquera, Adriana Carolina Prada-Ruiz, Traci Gonzales, Deborah L. Brown, Neethu M. Menon, Trinh T. Nguyen, Cindy K. Jon, Aravind YadavMcGovern Medical School at the University of Texas Health Science Center at Houston. Ponce Health Science University and Ponce Research Institute. Baylor

Pulmonary hypertension screening in children with sickle cell disease Read More »

A nomogram prediction model for early death in patients with persistent pulmonary hypertension of the newborn

Chuyang Lin, Jiao Mi, Yinyue Zhang†, Sichen Duan, Jinlin Wu, Yifei LiWest China Second University Hospital and Sichuan University.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: DOI: 10.3389/fcvm.2022.1077339 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a major lethal disorder in neonates that leads to an extremely high mortality rate. Thus, the early identification of

A nomogram prediction model for early death in patients with persistent pulmonary hypertension of the newborn Read More »

Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity

Eman El-Khateeb, Sahar Mohamed El-Haggar, Osama El-Razaky, Mohamed Ramadan El-Shanshory, Tarek Mohamed Mostafa68904Tanta University.United Kingdom and Egypt Journal of Cardiovascular Pharmacology and TherapeuticsJ Cardiovasc Pharmacol Ther 2022; DOI: 10.1177/10742484221132671 AbstractBackground: Pulmonary hypertension (PHT) is common in β-thalassemia patients due to hemolysis, iron overload and diminished nitric oxide (NO) levels. Biochemical markers can help to understand the pathophysiology and to introduce new therapies for this condition.Aim: This study

Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity Read More »

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

Ryan J. Carpenter, Nina Srdanovic, Karen Rychlik, Shawn K. Sen, Nicholas F. M. Porta, Aaron E. Hamvas, Karna Murthy, Amanda L. HauckLurie Children’s Hospital of Chicago and Northwestern University.United States Journal of PerinatologyJ Perinatol 2022; 42: 788-795DOI: 10.1038/s41372-022-01386-6 AbstractObjective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia Read More »

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