Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease

Systemic sclerosis sine scleroderma in children is more aggressive than in adults

Francesca Tirelli, Elisabetta Zanatta, Beatrice Moccaldi, Marco Binda, Giorgia Martini, Chiara Giraudo, Fabio Vittadello, Alessandra Meneghel, Francesco ZulianUniversity of Padova. Italy RheumatologyRheumatology 2024; DOI: 10.1093/rheumatology/keae304 AbstractObjectives: To compare the clinical and laboratory features of pediatric systemic sclerosis sine scleroderma (ssJSSc) with adult-onset ssSSc.Methods: Demographic, clinical and laboratory data of ssJSSc, retrospectively retrieved from our hospital medical records, case […]

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NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea

Xiaoting Yangzhong, Shu Hua, Yiqiong Wen, Xiaoqing Bi, Min Li, Yuanyuan Zheng, Shibo SunFirst Affiliated Hospital, Kunming Medical University.China Current Molecular MedicineCurr Mol Med 2024; DOI: 10.2174/0115665240294605240426123650 AbstractObstructive sleep apnea [OSA] is widespread in the population and affects as many as one billion people worldwide. OSA is associated with dysfunction of the brain system that controls

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Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies

Tsampika-Vasileia Kalamara, Konstantino Dodos, Efthymia VlachakiHippokration General Hospital and Aristotle University of Thessaloniki.Greece Frontiers in MedicineFront Med 2023; 10: DOI: 10.3389/fmed.2023.1259785 AbstractIntroduction: Thromboembolism (TE) and pulmonary hypertension (PH) constitute frequently occurring complications in patients with transfusion-dependent thalassemia and have been associated with splenectomy in different studies. Nevertheless, the size of the possible association varies greatly in literature. Herein,

Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies Read More »

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Mikala C. Mueller, Yanmei Du, Lori A. Walker, Chelsea M. MaginUniversity of Colorado, Anschutz Medical Campus.United States Matrix Biology PlusMatrix Biol Plus 2024; DOI: 10.1016/j.mbplus.2024.100145 AbstractRespiratory diseases like pulmonary arterial hypertension (PAH) frequently exhibit sexual dimorphism. Female PAH patients are more susceptible to the disease but have increased survival rates. This phenomenon is known as the

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Anesthetic challenges in patients with multicompartmental lymphatic failure after Fontan palliation undergoing transcatheter thoracic duct decompression

Kristen R. Groody, Susan C. Nicolson, David R. JobesChildren’s Hospital of Philadelphia. University of Michigan.United States Paediatric AnaesthesiaPaediatr Anaesth 2024; DOI: 10.1111/pan.14891 AbstractLymphatic flow abnormalities are central to the development of protein losing enteropathy, plastic bronchitis, ascites and pleural effusions in patients palliated to the Fontan circulation. These complications can occur in isolation or multicompartmental (two

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Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

Stefan Muenster, Iratxe Zarragoikoetxea, Andrea Moscatelli, Joan Balcells, Philippe Gaudard, Philippe Pouard, Nandor Marczin, Stefan P. JanssensUniversity Hospital Bonn. Hospital Universitari I Politècnic Fe. IRCCS Istituto Giannina Gaslini. Universitari Vall d’Hebron. University of Montpellier. Assistance Publique-Hopitaux de Paris and Hopital Necker-Enfants Malades. Imperial College. University Hospital Leuven.Germany, Spain, Italy, France, United Kingdom and Belgium Frontiers

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Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders

Haoran Shen, Rui Zheng, Mulong Du, David C. ChristianiNanjing Medical University. Harvard T.H. Chan School of Public Health. Massachusetts General Hospital.China and United States ThoraxThorax 2024; DOI: 10.1136/thorax-2023-221302 AbstractBackground: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the

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Causal association of depression, anxiety, cognitive performance, the brain cortical structure with pulmonary arterial hypertension: A Mendelian randomization study

Zeying Zhang, Shelby Kutty, Wei Peng, Gaoming Zeng, Haiyan Luo, Zhenghui Xiao, Qiming Liu, Yunbin XiaoSecond Xiangya Hospital of Central South University. Johns Hopkins School of Medicine. Hunan Children’s Hospital. China Journal of Affective DisordersJ Affect Dis 2024;DOI: 10.1016/j.jad.2024.01.276 AbstractBackground: Patients with pulmonary arterial hypertension (PAH) often present with anxiety, depression and cognitive deterioration. Structural changes in

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Low global arginine bioavailability: a common phenomenon in pulmonary hypertension

Dunia Hatabah, Teresa De Marco, Dana P. McGlothlin, Mary Malloy, Loretta Z. Reyes, Rawan Korman, Gregory J. Kato, Claudia R. MorrisEmory University School of Medicine. University of California, San Francisco. Kaiser Permanente San Francisco. Children’s Healthcare of Atlanta. Blood Science Consulting.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell

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The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a Sine Qua Non for True Therapeutic Success in Pulmonary Arterial Hypertension

David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Nathan Messas, Michele Giovinazzo, John D. CatravasJewish General Hospital and McGill University. Evangelismos Hospital and National and Kapodistrian University of Athens Medical School. Yitzchak Shamir Hospital and Tel Aviv University. Old Dominion University.Canada, Greece, Israel and United States Journal of Clinical MedicineJ Clin Med 2022; 11:DOI: 10.3390/jcm11154568 AbstractExercise-induced

The Paradox of Pulmonary Vascular Resistance: Restoration of Pulmonary Capillary Recruitment as a Sine Qua Non for True Therapeutic Success in Pulmonary Arterial Hypertension Read More »

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