Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease

Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended-release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment

Xuemei Wu, Xiaohan Zhang, Ruichao Xu, Imam Hussain Shaik, Raman VenkataramananUniversity of Pittsburgh School of Pharmacy. Fujian Medical University Union Hospital. University of Virginia. University of Pittsburgh School of Medicine.United States and China British Journal of Clinical PharmacologyBrit J Clin Pharmacol 2022; 88: 587-599DOI: 10.1111/bcp.14966 AbstractAims: Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary arterial pressure, […]

Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended-release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment Read More »

Construction and Evaluation of a Bio-Engineered Pump to Enable Subpulmonary Support of the Fontan Circulation: A Proof-of-Concept Study

Christopher R. Broda, P. Alex Smith, Yaxin Wang, Hamsini Sriraman, Peter S. Owuor, Luiz C. Sampaio, Iki Adachi, Doris A. Taylor, Christopher R. Broda, P. Alex Smith, Yaxin Wang, Hamsini Sriraman, Peter S. OwuorBaylor College of Medicine and Texas Children’s Hospital. Texas Medical Center. Texas Heart Institute. Pennsylvania State University. University of Texas Health Science

Construction and Evaluation of a Bio-Engineered Pump to Enable Subpulmonary Support of the Fontan Circulation: A Proof-of-Concept Study Read More »

Cardiovascular magnetic resonance in autoimmune rheumatic diseases: a clinical consensus document by the European Association of Cardiovascular Imaging

S. Mavrogeni, A. Pepe, K. R. Nijveldt, N. Ntusi, L.M. Sierra-Galan, Bratis, J. Wei, M. Mukherjee, G. Markousis-Mavrogenis, L. Gargani, L.E. Sade, N. Ajmone-Marsan, M. P. Seferovic, E. Donal, Nurmohamed, M. Matucci Cerinic, P. Sfikakis, G. Kitas, J. Schwitter, J. A. C. Lima, Dana Dawson, Marc Dweck, Kristina H. Haugaa, Niall Keenan, James Moon, Ivan

Cardiovascular magnetic resonance in autoimmune rheumatic diseases: a clinical consensus document by the European Association of Cardiovascular Imaging Read More »

Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target

Katharina Schimmel, Kenzo Ichimura, Sushma Reddy, Francois Haddad, Edda SpiekerkoetterStanford University School of Medicine. United States Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: DOI: 10.3389/fcvm.2022.886553 AbstractMyocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following cardiac stress. “Replacement fibrosis” is a term used to describe wound healing in the acute phase of an

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Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis

Maria Anifanti, Stavros Giannakoulakos, Elpis Hatziagorou, Asterios Kampouras, John Tsanakas, Asterios Deligiannis, Evangelia KouidiAristotle University of Thessaloniki and Hippokration Hospital. Greece SensorsSensors 2022; 22: DOI: 10.3390/s22134884 AbstractSeveral studies have shown that patients with cystic fibrosis (CF), even at a young age, have pulmonary and cardiac abnormalities. The main complications are cardiac right ventricular (RV) systolic and/or

Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis Read More »

Natural history of Myhre syndrome

David Dawei Yang, Marlene Rio, Caroline Michot, Nathalie Boddaert, Wael Yacoub, Nicolas Garcelon, Briac Thierry, Damien Bonnet, Sophie Rondeau, Dominique Herve, Stephanie Guey, Francois Angoulvant, Valerie Cormier‑DaireUniversité de Paris. Hôpital Universitaire Necker-Enfants Malades. INSERM U. Hôpital Lariboisière. France Orphanet Journal of Rare DiseasesOrphanet J Rare Dis 2022; 17: DOI: 10.1186/s13023-022-02447-x AbstractBackground: Myhre syndrome (MS) is a rare

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A unique gut microbiota signature in pulmonary arterial hypertension: A pilot study

Arun Jose, Senu Apewokin, Walaa E. Hussein, Nicholas J. Ollberding, Jean M. Elwing, David B. HaslamUniversity of Cincinnati. Cincinnati Children’s Hospital Medical Center.United States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12051 AbstractPulmonary arterial hypertension (PAH) is a progressive, ultimately fatal cardiopulmonary disease associated with a number of physiologic changes, which is believed to result in imbalances

A unique gut microbiota signature in pulmonary arterial hypertension: A pilot study Read More »

Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major

Azza Abdel Gawad Tantawy, Mourad Alfy Ramzy Tadros, Amira Abdel Moneam Adly, Eman Abdel Rahman Ismail, Fatma A. Ibrahim, Nanis Mohammed Salah Eldin, Mahitab Morsy Hussein, Mervat Abdalhameed Alfeky, Sarah Mohammed Ibrahim, Marwa Adel Hashem, Fatma Soliman Elsayed EbeidAin Shams University. Military Medical Services and Military Medical Academy.Egypt CytokineCytokine 2023; 161: DOI: 10.1016/j.cyto.2022.156048 AbstractBackground: Endothelin-1 (ET-1), a potent endogenous vasoconstrictor, stimulates production of reactive oxygen species. Endothelial monocyte-activating polypeptide-II (EMAP-II) is a multifunctional polypeptide.Aim: To assess ET-1 gene polymorphism

Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major Read More »

The long-term efficacy in blood transfusions, hematologic parameter changes, and complications after splenectomy in patients with transfusion-dependent thalassemia

Nichanan Osataphan, Somying Dumnil, Adisak Tantiworawit, Teerachat Punnachet, Nonthakorn Hantrakun, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Kanda Fanhchaksai, Pimlak CharoenkwanChiang Mai University. Thailand Transfusion and Apheresis ScienceTransfus Apher Sci 2022; DOI: 10.1016/j.transci.2022.103620 AbstractBackground: A splenectomy can reduce transfusion requirements in patients with thalassemia. However, the role of a splenectomy remains controversial

The long-term efficacy in blood transfusions, hematologic parameter changes, and complications after splenectomy in patients with transfusion-dependent thalassemia Read More »

Hemodynamic Characteristics After Fontan Procedure in Patients with Down’s Syndrome

Masakazu Otsuka, Yoshihiko Kodama, Ayako Kuraoka, Yuichi Ishikawa, Makoto Nakamura, Toshihide Nakano, Hideaki Kado, Shintaro Umemoto, Ayako Ishikita, Ichiro Sakamoto, Tomomi Ide, Hiroyuki Tsutsui, Koichi SagawaFukuoka Children’s Hospital. Kyushu University Hospital.Japan Pediatric CardiologyPediatr Cardiol 2022; 43: 360-365DOI: 10.1007/s00246-021-02727-6 AbstractPatients with Down’s syndrome (DS) are generally regarded as not being good candidates for the Fontan procedure. However,

Hemodynamic Characteristics After Fontan Procedure in Patients with Down’s Syndrome Read More »

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