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Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension

Nicolas Philip, Xin Yun, Hongyang Pi, Samuel Murray, Zack Hill, Jay Fonticella, Preston Perez, Cissy Zhang, Wimal Pathmasiri, Susan Sumner, Laura Servinsky, Haiyang Jiang, John C. Huetsch, William M. Oldham, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Evan Brittain, Catherine E. Simpson, Anne Le, Larissa A. Shimoda, Karthik SureshJohns Hopkins University School of Medicine. […]

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Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling

Ling Tang, Xiao Zhou, Aili Guo, Lizhang Han, Silin PanJinan Central Hospital. Central Hosptial. Qilu Hospital. Qingdao Women and Children’s Hospital. Shandong University.China Cardiovascular ToxicologyCardiovasc Toxicol 2024;DOI: 10.1007/s12012-023-09822-5 AbstractHigh expression of the zinc finger X-chromosomal protein (ZFX) correlates with proliferation, aggressiveness, and development in many types of cancers. In the current report, we investigated the efficacy

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling Read More »

Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling

Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D. Korman, Sara O. Vargas, Joseph C. Wu, Kurt R. Stenmark, Vinicio de Jesus Perez, Mark R. Nicolls,Benjamin A. Raby, Ke Yuan European Molecular

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Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension

Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins,

Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension Read More »

Tumor Necrosis Factor-α-Induced Protein-8-like 2 Transfected Adipose-Derived Stem Cells Regulated the Dysfunction of Monocrotaline Pyrrole-Induced Pulmonary Arterial Smooth Muscle Cells and Pulmonary Arterial Endothelial Cells

Jing Li, Xin He, Feng Liu, Kinglong Zheng, Jing JiangFirst Affiliated Hospital of Xi’an Jiaotong University. Fourth Military Medical University.China Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2024; 83:73-85DOI: 10.1097/FJC.0000000000001505 AbstractPulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) activation. For decades, the therapies for PAH

Tumor Necrosis Factor-α-Induced Protein-8-like 2 Transfected Adipose-Derived Stem Cells Regulated the Dysfunction of Monocrotaline Pyrrole-Induced Pulmonary Arterial Smooth Muscle Cells and Pulmonary Arterial Endothelial Cells Read More »

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

Manivannan Yegambaram, Xutong Sun, Alejandro Garcia Flores, Qing Lu, Jamie Soto, Jaime Richards, Saurabh Aggarwal, Ting Wang, Haiwei Gu, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2023; 24:DOI: 10.3390/ijms242417533 AbstractThe disruption of mitochondrial dynamics has been identified in cardiovascular diseases, including

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells Read More »

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Yi‑Chia Wu, Wei‑Ting Wang, Ming‑Chun Yang, Yu‑Tsun Su, Jwu‑Lai Yeh, Jong‑Hau Hsu, Jiunn‑Ren WuKaohsiung Medical University Hospital and Kaohsiung Medical University. Kaohsiung Municipal Ta-Tung Hospital. E-Da Hospital and I-Shou University.Taiwan Biological ResearchBiol Res 2023; DOI: 10.1186/s40659-023-00480-z AbstractBackground: Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension Read More »

Inhalable Nitric Oxide Delivery Systems for Pulmonary Arterial Hypertension Treatment

Yoogyeong Oh, Kyungtae Park, Sungwon Jung, Moonhyun Choi, Taihyun Kim, Yoojin Kim, Yoojin Lee, Jae Young Choi, Yang-Hee Kim, Se Yong Jung, Jinkee HongYonsei University College of Medicine. University of Southampton.Republic of Korea and United Kingdom SmallSmall 2023; DOI: 10.1002/smll.202308936 AbstractPulmonary arterial hypertension (PAH) is a severe medical condition characterized by elevated blood pressure in the

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Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C. U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwarzHarper Cancer Research Institute and University of Notre Dame.United States Circulation ResearchCirc Res 2023; 133: 704-719DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao1, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene RabinovitchLucile Packard Children’s Hospital and Stanford University School of Medicine. University Medical Center

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension Read More »

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