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Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M. KUonig, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K. Fleischmann, Daniela WenzelUniversity Hospital of the Ruhr University of Bochum and Ruhr University of Bochum. University Hospital of Nottingham. Massachusetts General Hospital and Harvard Medical School. University of […]

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High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin XiaoUniversity of South China. Affiliated Children’s Hospital of Xiangya School of Medicine. Third Xiangya Hospital. Second Xiangya Hospital. Central South University. Changsha Yali High School. China Journal of Cardiovascular Translational

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Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition

Xinyu Lia, Hui Li, Bo Feng, Xiaoyan Chen, Ting Chen, Jiafei Lu, Huating Xie, Nana Su, Houlin Chen, Chenghao Lou, Runxin Zhuang, Xi Chen, Shengwei Jin, Yu HaoSecond Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Ruijin Hospital and Shanghai Jiao Tong University School of Medicine. China Biomedicine and PharmacotherapyBiomed Pharmacother 2024; DOI: 10.1016/j.biopha.2024.117023

Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition Read More »

Fibroblasts in Pulmonary Hypertension: Roles and Molecular Mechanisms

Hui Zhang, Min Li, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado School of Medicine and School of Dental Medicine.United States CellsCells 2024; 13: DOI: 10.3390/cells13110914 AbstractFibroblasts, among the most prevalent and widely distributed cell types in the human body, play a crucial role in defining tissue structure. They do this by depositing and remodeling extracellular matrixes

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Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in mice

Xiao-Qing Sun, Timothy Klouda, Suzanne Barnasconi, Ingrid Schalij, Janne Schwab, Anders Hammer Nielsen-Kudsk, Julie Sørensen Axelsen, Asger Andersen, Jurjan Aman, Frances S. de Man, Harm Jan Bogaard, Ke Yuan, Keimei YoshidaAmsterdam UMC. Boston Children’s Hospital. Aarhus University Hospital.Netherlands, United States and Denmark American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell

Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in mice Read More »

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension

Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. GrahamUniversity of California, San Francisco and Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. United States Frontiers in ImmunologyFront Immunol 2024; DOI: 10.3389/fimmu.2024.1372957 AbstractBackground: Schistosomiasis

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3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension

Kenzo Ichimura, Mario Boehm, Adam M. Andruska, Fan Zhang, Katharina Schimmel, Spencer Bonham, Angela Kabiri, Vitaly O. Kheyfets, Shoko Ichimura, Sushma Reddy, Yuqiang Mao, Tianyi Zhang, Gordon Wang, Everton J. Santana, Xuefei Tian, Ilham Essafri, Ryan Vinh, Wen Tian, Mark R. Nicolls, Shin Yajima, Yasuhiro Shudo, John W. McArthur, Y. Joseph Woo, Ross J. Metzger,

3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension Read More »

Effect of Estrogen Receptor Alpha on Cardiopulmonary Adaptation to Chronic Developmental Hypoxia in a Rat Model

Nicholas T. Severyn, Patricia Esparza, Huanling Gao, Elizabeth A. Mickler, Marjorie E. Albrecht, Amanda Fisher, Bakhtiyor Yakubov, Todd G. Cook, James E. Slaven, Avram D. Walts, Robert S. Tepper, Tim LahmUniversity of Kentucky. Indiana University – Purdue University Indianapolis. University of Colorado. National Jewish Health.United States American Journal of Physiology Lung Cellular and Respiratory PhysiologyAm

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United

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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension Read More »

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