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Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension

Mohammad Shafiq, Zahid Rasool Lone, Adam Olaitan Abdulkareem, Gurpreet Kaur, Sai Navya, Himalaya Singh, Kumaravelu Jagavelu, Kashif HanifCSIR-Central Drug Research Institute and Academy of Scientific and Innovative Research. Ann & Robert H. Lurie Children’s Hospital. University of Illorin.India and United States Pulmonary Pharmacology and TherapeuticsPulm Pharmacol Ther 2023; 80: DOI: 10.1016/j.pupt.2023.102200 AbstractEndothelial dysfunction is critical in […]

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Novel Loss of Function KCNA5 Variants in Pulmonary Arterial Hypertension

Alba Vera-Zambrano, Mauro Lago-Docampo, Natalia Gallego, Juan Felipe Franco-Gonzalez, Daniel Morales-Cano, Alejandro Cruz-Utrilla, Marta Villegas-Esguevillas, Edgar Fernandez-Malave, Pilar Escribano-Subias, Jair Antonio-Tenorio-Castano, Francisco Perez-Vizcaino, Diana Valverde, Teresa Gonzalez, Angel CogolludoUniversidad Complutense de Madrid Facultad de Medicina. Universidad Autonoma de Madrid Facultad de Medicina. Instituto de Investigaciones Biomedicas Alberto Sols. Universidad de Vigo. Galicia Sur Health Research

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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension

Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala DakshinamurtiChildren’s Hospital Research Institute of Manitoba and University of Manitoba.Canada Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1144574 AbstractIntroduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in

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Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Qing Lu, Xutong Sun, Manivannan Yegambaram, Wojciech Ornatowski, Xiaomin Wu, Hui Wang, Alejandro Garcia-Flores, Victoria Da Silva, Evgen A. Zemskov, Haiyang Tang, Jeffrey R. Fineman, Kim Tieu,Ting Wang, Stephen M. BlackFlorida International University. University of Arizona Health Sciences. University of California San Francisco. United States Journal of Biological ChemistryJ Biol Chem 2023; 299:DOI: 10.1016/j.jbc.2023.103067 AbstractMitochondrial fission

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission Read More »

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

Miranda K. Culley, Rashmi J. Rao, Monica Mehta, Jingsi Zhao, Wadih El Khoury, Lloyd D. Harvey, Dror Perk, Yi Yin Tai, Ying Tang, Sruti Shiva, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y. ChanUniversity of Pittsburgh School of Medicine and University of Pittsburgh Medical Center. Albert Einstein College of Medicine. Stanford Children’s Health and Stanford

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function Read More »

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of California San Francisco. Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. Stanford University. Universidade de Pernambuco.United States and Brazil

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension Read More »

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model

Yi Peng, Jingbo Dai, You-Yang ZhaoAnn and Robert H. Lurie Children’s Hospital of Chicago. Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24032391 AbstractPulmonary arterial hypertension (PAH) is a progressive and inevitably fatal disease characterized by the progressive increase of pulmonary vascular resistance and obliterative

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model Read More »

The Anti-Inflammatory Effects and Clinical Potential of Dexmedetomidine in Pulmonary Arterial Hypertension

Yohei Yamaguchi, Susumu Hosokawa, Go Haraguchi, Yusuke Kajikawa, Makito Sakurai, Taku Ishii, Noboru Ando, Tomohiro Morio, Shozaburo Doi, Tetsushi FurukawaTokyo Medical and Dental University. Saitama Children’s Medical Center. National Hospital Organization Disaster Medical Center. Japan Journal of Pharmacology and Experimental TherapeuticsJ Pharmacol Exp Ther 2023; 385: 88-94DOI: 10.1124/jpet.122.001399 AbstractA pathogenic aspect of pulmonary arterial hypertension (PAH) is the aberrant pulmonary arterial smooth muscle cell

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Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension

Hui Zhang, Angelo D’Alessandro, Min Li, Julie A. Reisz, Suzette Riddle, Akshay Muralidhar, Todd Bull, Lan Zhao, Evgenia Gerasimovskaya, Kurt R. StenmarkUniversity of Colorado School of Medicine.  Imperial College London. United States and United Kingdom Vascular PharmacologyVasc Pharmacol 2023; 149: DOI: 10.1016/j.vph.2023.107157 AbstractRationale: Sildenafil, a well-known vasodilator known to interfere with purinergic signaling through effects on cGMP,

Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension Read More »

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertension after C75 treatment

Cuilan Hou, Lijian Xie, Tingxia Wang, Junmin Zheng, Yuqi Zhao, Qingzhu Qiu, Yi Yang, Tingting XiaoShanghai Children’s Hospital and Shanghai Jiao Tong University. NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology. Jin Shan Hospital and Fudan University. The Children’s Hospital and Zhejiang University School of Medicine. China BioMed Central Pulmonary MedicineBMC Pulm Med

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertension after C75 treatment Read More »

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