Medical Therapy. Adverse Effects or Lack of Adverse Effects

Bleeding Complications in Neonates Receiving Extracorporeal Membrane Oxygenation and Controlled Hypothermia

Swosti Joshi, Vilmaris Quinones Cardona, Erica Poletto, Ogechukwu MenkitiDrexel University College of Medicine Philadelphia. Saint Christopher’s Hospital for Children.United States American Journal of PerinatologyAm J Perinatol 2022; DOI: 10.1055/a-1786-8688 AbstractObjective: Safety and efficacy data on controlled hypothermia (CH) for neonates with moderate to severe hypoxic ischemic encephalopathy has been extrapolated to a subgroup of these patients who […]

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Pulmonary vasodilator therapies in pulmonary arterial hypertension associated with CHD: a systematic review and network meta-analysis

Jun Yasuhara, Kae Watanabe, Atsuyuki Watanabe, Takuro Shirasu, Yuichi Matsuzaki, Hirofumi Watanabe, Hisato Takagi, Naokata Sumitomo, Toshiki KunoNationwide Children’s Hospital. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. University of Tsukuba Hospital. University of Virginia. McGill University. Medical University of South Carolina. Shizuoka Medical Center. Saitama Medical

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Implementation of an Inhaled Nitric Oxide Weaning Protocol and Stewardship in a Level 4 NICU to Decrease Inappropriate Use

Walid A. Hussain, Deborah S. Bondi, Pooja Shah, Sherwin E. Morgan, Sudhir Sriram, Michael D. SchreiberLoyola University Medical Center. University of Chicago Medicine Comer Children’s Hospital. United States Journal of Pediatric Pharmacology and TherapeuticsJ Pediatr Pharmacol Ther 2022; 27: 284-291DOI: 10.5863/1551-6776-27.3.284 AbstractObjective: Inhaled nitric oxide (iNO) is an effective but expensive treatment of pulmonary hypertension in newborns,

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Oral hymecromone decreases hyaluronan in human study participants

Joelle I. Rosser, Nadine Nagy, Riya Goel, Gernot Kaber, Sally Demirdjian, Jamie Saxena, Jennifer B. Bollyky, Adam R. Frymoyer, Ana E. Pacheco-Navarro, Elizabeth B. Burgener, Jayakumar Rajadas, Zhe Wang, Olga Arbach, Colleen E. Dunn, Anissa Kalinowski, Carlos E. Milla, Paul L. BollykyStanford University. UCSF School of Pharmacy. Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin

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Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series

Swosti Joshi, Vilmaris Quinones Cardona, Ogechukwu R. MenkitiDrexel University College of Medicine and St. Christopher’s Hospital for Children.United States SAGE Medical Case ReportsSAGE Med Cas Rep 2022; DOI: 10.1177/2050313X221102289 AbstractTreatment of neonates with persistent pulmonary hypertension of newborn includes optimization of ventilatory support, use of pulmonary vasodilators, and/or inotropic support. If refractory to this management, some

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Acute Pulmonary Vasodilator Testing and Long-Term Clinical Course in Segmental Pulmonary Vascular Disease

Liezl Domingo, H. Sonali Magdo, Ronald W. DayUniversity of Utah and Primary Children’s Hospital.United States Pediatric CardiologyPediatr Cardiol 2018; 39: 501-508DOI: 10.1007/s00246-017-1780-9 AbstractResults of acute pulmonary vasodilator testing (AVT) and the outcome of medical therapy have not been described in patients with segmental pulmonary vascular disease (SPVD). We sought to compare the pulmonary vasodilatory effects of

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Use of Pulmonary Arterial Hypertension Therapies in Patients with a Fontan Circulation: Current Practice Across the United Kingdom

Andrew Constantine, Robert M. R. Tulloh, Konstantinos Dimopoulos, Petra Jenkins, Robin Condliffe, Katrijn Jansen, Natali A. Y. Chung, James Oliver, Helen Parry, Samantha Fitzsimmons, Niki Walker, Stephen John Wort, Vasilios Papaioannou, Kate von Klemperer, Paul CliftRoyal Brompton HospitalRoyal Brompton and Harefield Hospitals. Imperial College London. Liverpool Heart and Chest Hospital. University Hospital Bristol. Royal Hallamshire

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Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn

Sourabh Verma, Rishi Lumba, Sadaf H. Kazmi, Michelle J. Vaz, Shrawani Soorneela Prakash, Sean M. Bailey, Pradeep V. Mally, Tara M. RandisNYU Grossman School of Medicine. University of South Florida. United States American Journal of PerinatologyAm J Perinatol 2022; 39: 1441-1448DOI: 10.1055/s-0040-1722653 AbstractObjective: The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in

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Milrinone Versus Sildenafil in Treatment of Neonatal Persistent Pulmonary Hypertension: A Randomized Control Trial

Safaa S. Iman, Rania A. El-Farrash, Amr S. Taha, Ghada A. SalehAin Shams University and Cairo Ministry of Health.Egypt Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2022; 80: 746-752DOI: 10.1097/FJC.0000000000001332 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a condition caused by failure of pulmonary vascular adaptation at birth, resulting in severe hypoxia. Several therapeutic modalities are

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Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study

Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel GanzevoortUniversity of Amsterdam and Emma Children’s Hospital. University of Groningen, University Medical Center Groningen and Beatrix Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Leiden University Medical Center. Erasmus University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2022; 181: 1709-1718DOI: 10.1007/s00431-021-04355-x AbstractThe aim was

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