Medical Therapy. Adverse Effects or Lack of Adverse Effects

Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins

Fatemeh Kohram, Zicheng Deng, Yufang Zhang, Abid Al Reza, Enhong Li, Olena A Kolesnichenko, Samriddhi Shukla, Vladimir Ustiyan, Jose Gomez-Arroyo, Anusha Acharya, Donglu Shi, Vladimir V. Kalinichenko, Alan P. KennyUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center and University of Cincinnati.United States BiologicsBiologics 2023; 17: 43-55DOI: 10.2147/BTT.S400006 AbstractIntroduction: Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins (ACDMPV) […]

Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins Read More »

Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease

Pauline de Jager, Martha A. Q. Curley, Ira M. Cheifetz, Martin C. J. KneyberBeatrix Children’s Hospital and University Medical Center Groningen. Children’s Hospital of Philadelphia and University of Pennsylvania. Rainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Netherlands and United States Pediatric Critical Care MedicinePediatr Crit Care Med 2023; DOI: 10.1097/PCC.0000000000003211

Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease Read More »

Assessment of the effect of two regimens of milrinone infusion in paediatric patients with pulmonary artery hypertension undergoing corrective cardiac procedure: A prospective observational study

Mrugesh Prajapati, Jigar Patel, Hasmukh Patel, Hemang Gandhi, Guriqbal Singh, Pravin PatelU.N. Mehta Institute of Cardiology and Research CenterIndia Annals of Pediatric CardiologyAnn Pediatr Cardiol 2022; 15: 358-363DOI: 10.4103/apc.apc_230_21 AbstractBackground: The aim of the study was to compare the effect of two different regimens of milrinone in pediatric patients with pulmonary artery hypertension (PAH) undergoing corrective procedure.Materials

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Asystole in 2 Pediatric Patients During Dexmedetomidine Infusion

Katrin Lichtsinn, Ila Sehgal, Alexandra WilsonUniversity of Texas at Austin, Dell Medical School and Dell Children’s AscensionUnited States Journal of Pharmacy PracticeJ Pharm Pract 2023; 36: 176-179DOI: 10.1177/08971900211027133 AbstractIntroduction: Bradycardia is a known side effect of dexmedetomidine. Reports of sinus pauses or asystole, however, are rare. We present 2 cases of pediatric patients who developed asystole on

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Treprostinil in Neonates with Congenital Diaphragmatic Hernia-Related Pulmonary Hypertension

Felix R. De Bie, Catherine M. Avitabile, Sabrina Flohr, Sierra Land, Leny Mathew, Yan Wang, Devon Ash, Natalie E. Rintoul, Holly L. HedrickChildren’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Cluster Woman and Child. United States and Belgium Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113420 AbstractObjective: To describe our experience with treprostinil, evaluate

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Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis

Fen Cao, Kun Wu, Yongzhi Zhu, Junjun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhongwu BaoHuaihua First People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2023; 9: DOI: 10.3389/fcvm.2022.1055897 AbstractBackground: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by pulmonary vascular remodeling and increased pulmonary artery pressure, leading

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis Read More »

Case Report: Selexipag in pediatric pulmonary hypertension: Initiation, transition, and titration

Jenna M. Faircloth, Neelam D. Bhatt, Corey A. Chartan, Ryan D. Coleman, Natalie Villafranco, Fadel E. Ruiz, Raysa Morales-Demori, Elise Whalen, Erin Ely, Rozmeen Fombin, Nidhy P. VargheseTexas Children’s Hospital and Baylor College of Medicine.United States Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1050508 AbstractSelexipag, a selective prostacyclin receptor agonist, is approved for treating pulmonary arterial

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Propranolol Therapy for Congenital Chylothorax

Roxane Handel-Orefice, Bevin Midura, June K. Wu, Elvira Parravicini, Russell S. Miller, Carrie J. ShawberColumbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children’s HospitalUnited States PediatricsPediatrics 2023; 151: DOI: 10.1542/peds.2022-058555 AbstractCongenital chylothorax is a rare and often severe anomaly without well-established medical therapies. Previously, propranolol use in patients with lymphatic malformations

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Safety of chronic high-dose calcium channel blockers exposure in children with pulmonary arterial hypertension

Yan Wu, Fu-Hua Peng, Xin Gao, Xin-Xin Yan, FengWen Zhang, Jiang-Shan Tan, Song Hu, Lu HuaFuwai Hospital and Chinese Academy of Medical Sciences and Peking Union Medical College.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.918735 AbstractBackground: Chronic calcium channel blockers (CCBs) are indicated in children with idiopathic/heritable pulmonary arterial hypertension (IPAH/HPAH) and positive response to

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Home High-Flow Nasal Cannula Therapy in Children with Congenital Heart Disease

Yuka Hanaki, Jun Muneuchi, Junko Yamamoto, Chie Yokota, Junya Ohmura, Hiroki Ezaki, Miwa Yoshino, Ryoko Nakamura, Miho Takeichi, Yuichiro Sugitani, Ryouhei Matsuoka, Hirohito Doi, Mamie Watanabe, Yasukiko TakahashiKyushu Hospital and Japan Community Healthcare Organization. Japan Pediatric CardiologyPediatr Cardiol 2022; 43: 1131-1135DOI: 10.1007/s00246-022-02834-y AbstractHigh-flow nasal cannula (HFNC) therapy has been applied in the perioperative respiratory care for

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