Mechanical and Computer Models of Pulmonary Vascular Disease

A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics

Jason M. Szafron, Weiguang Yang, Jeffrey A. Feinstein, Marlene Rabinovitch, Alison L. MarsdenStanford University.United States Biomechanics and Modeling in MechanobiologyBiomech Model Mechanobiol 2023; DOI: 10.1007/s10237-023-01744-z AbstractHemodynamic loading is known to contribute to the development and progression of pulmonary arterial hypertension (PAH). This loading drives changes in mechanobiological stimuli that affect cellular phenotypes and lead to pulmonary […]

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Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively

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Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study

Rachelle Walter, Kendall Hunter, Kurt Stenmark, Vitaly O. KheyfetsUniversity of ColoradoUnited States Journal of Biomechanical EngineeringJ Biomech Eng 2022; 144: DOI: 10.1115/1.4051719 AbstractPulmonary hypertension (PH) is a progressive disease that is characterized by a gradual increase in both resistive and reactive pulmonary arterial (PA) impedance. Previous studies in a rodent model of PH have shown that

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