Mechanical and Computer Models of Pulmonary Vascular Disease

A Computational Framework for Quantifying Hemodynamic Burden in Pediatric Pulmonary Vein Stenosis

Manish Bansal, Dan Lior, Avishek Mukherjee, Jeffrey S. Heinle, Athar M. Qureshi, Charles Puelz, Ravi K. BirlaTexas Children’s Hospital and Baylor College of Medicine. University of Houston. United States Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2026; DOI: 10.1016/j.jtcvs.2026.09.007 AbstractBackground: Pulmonary vein stenosis (PVS) is a rare but devastating pediatric disorder characterized by

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Developing a Digital Twin of the Cardiopulmonary System in a Mouse: Inferring Hemodynamics from Sparse Measurements

Vitaly O. Kheyfets, Kenzo Ichimura, Paul M. Heerdt, Mengqian Zhang, Ella Lyon, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado School of Medicine and University of Colorado Anschutz Medical Campus. Stanford University. Yale School of Medicine.United States Annals of Biomedical EngineeringAnn Biomed Eng 2026; DOI: 10.1007/s10439-026-04107-8 AbstractPurpose: The use of rodent models in the study of cardiopulmonary disease

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A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury

Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne HilgendorffHelmholtz Zentrum München and German Lung Research Center. University of Cambridge. University Hospital Ludwig-Maximilian University. Carl von Ossietzky University.Germany and United Kingdom American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00002.2026 AbstractPulmonary vascular disease (PVD) is

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Shunt configuration’s role in shaping hemodynamics of reverse Potts shunt in pediatric pulmonary arterial hypertension

Jinlong Liu, Xiafeng Yu, Jiwen Xiong, Yi Yan, Yanjun Sun, Yumin Zhong, Hao ZhangShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China Frontiers in Bioengineering and BiotechnologyFront Bioeng Biotechnol 2026; 13: DOI: 10.3389/fbioe.2025.1697468 AbstractObjectives: Reverse Potts shunt is a promising yet high-risk therapy for pediatric pulmonary arterial hypertension. Postoperative hemodynamics is critically influenced by

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Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior

Laura Yuriko González-Teshima, Keisuke Hakamada, Kozue Murata, Reiko Nakagawa, Shiro Baba, Yujiro Ide, Maiko Okamura, Akio Ikai, Tadashi Ikeda, Kenji Minatoya, Masaya Hagiwara, Masaya Ikegawa, Hidetoshi MasumotoKyoto University Graduate School of Medicine. RIKEN Center for Biosystems Dynamics Research. Doshisha University. Shizuoka General Hospital. Japan Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-25523-1 AbstractPulmonary arteriovenous malformations (PAVM) are

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Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model

Maria Niccum, Catherine M. Avitabile, Dana Albizem, Heather Meluskey, Christopher Penney, Brian D. Hanna, Michael L. O’Byrne, Zoheir Bshouty, David B. FrankPerelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia. University of Manitoba.United States and Canada Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70156 AbstractPediatric pulmonary arterial hypertension (PAH) has a long

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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Yifei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, Kentaro Iwasawa, Min Shi, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Debora I. Sinner, Xingchen Liu, Ko Chih Lin, Cheng-Lun Na, Keishi Kishimoto, Min-Chi Yang, Sushila Maharjan, Jason Tchieu, Jeffrey A. Whitsett, Yu Shrike Zhang, Kyle W. McCracken, Robbert J. Rottier, Darrell N. Kotton,

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Transcatheter Hepatic Conduit-Azygous Vein Connection Reduces Pulmonary Arteriovenous Malformations in a Cyanotic Fontan Patient

Kanishka Ratnayaka, Zhenglun A. Wei, Justin R. Ryan, Caitlin M. Heyden, Hari K. Narayan, Timothy C. Slesnick, Robert J. Lederman, John W. Moore, Ajit P. Yoganathan, Howaida G. El-SaidRady Children’s Hospital and University of California-San Diego. National Heart, Lung, and Blood Institute. University of Massachusetts Lowell. Children’s Healthcare of Atlanta, Georgia Institute of Technology and

Transcatheter Hepatic Conduit-Azygous Vein Connection Reduces Pulmonary Arteriovenous Malformations in a Cyanotic Fontan Patient Read More »

Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models

Mikala C. Mueller, Rachel Blomberg, Alicia E. Tanneberger, Duncan Davis-Hall, Keith B. Neeves, Chelsea M. MaginUniversity of Colorado. United States American Chemical Society Biomaterials Science and EngineeringACS Biomater Sci Eng 2025; DOI: 10.1021/acsbiomaterials.5c00123 AbstractPulmonary arterial hypertension (PAH) is a form of pulmonary vascular disease characterized by scarring of the small blood vessels that results in reduced

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Balloon Dilation Technique Influences Stent Shortening and Intentional Stent Fracture During Overexpansion of Drug-Eluting Stents: A Bench-Testing Study

Mudit Gupta, Ella B. Leeth, Yuval Barak-Corren, Ari J. Gartenberg, Elizabeth Silvestro, Michael L. O’Byrne, Ryan CallahanChildren’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Akron Children’s Hospital and Northeast Ohio Medical University.United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2025; DOI: 10.1002/ccd.31428 AbstractBackground and aims: Drug-eluting stents (DES) are not designed for overexpansion

Balloon Dilation Technique Influences Stent Shortening and Intentional Stent Fracture During Overexpansion of Drug-Eluting Stents: A Bench-Testing Study Read More »

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