Review Articles Concerning Pulmonary Vascular Disease

High-altitude Illnesses and Air Travel: Pediatric Considerations

Nelson Villca, Adriana Asturizaga, Alexandra Heath-FreudenthalHospital Materno Infantil. Hospital de la Banca Privada. Kardiozentrum.Bolivia Pediatric Clinics of North AmericaPediatr Clin North Am 2021; 68: 305-319 DOI: 10.1016/j.pcl.2020.09.015 AbstractHealthy children may present acute mountain sickness (AMS) within a few hours after arrival at high altitudes. In few cases, serious complications may occur, including high-altitude pulmonary edema and rarely […]

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Respiratory physiology at high altitude and considerations for pediatric patients

Zvonimir Bebic, Melissa Brooks Peterson, David M. PolanerUniversity of Colorado and Children’s Hospital Colorado. Seattle Children’s Hospital and University of Washington School of Medicine.United States Paediatric AnaesthesiaPaediatr Anaesth 2022; 32: 118-125DOI: 10.1111/pan.14380 AbstractOver 150 million people, including many children, live at high altitude (>2500 m) with the majority residing in Asia and South America. With increases

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Evolving Role of Three-Dimensional Echocardiography for Right Ventricle Volume Analysis in Pediatric Heart Disease: Literature Review and Clinical Applications

Alessandra M. Ferraro, David M. Harrild, Andrew J. Powell, Philip T. Levy, Gerald R. MarxBoston Children’s Hospital and Harvard Medical School. Sapienza University of Rome. United States and Italy Journal of the American Society of EchocardiographyJ Am Soc Echocardiogr 2024;DOI: 10.1016/j.echo.2024.03.001 AbstractAccurate knowledge of right ventricle (RV) volumes and ejection fraction is fundamental to providing optimal

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Review of electrical impedance tomography in the pediatric patient

S. Cabezudo Ballesteros, P. Sanabria Carretero, F. Reinoso BarberoHospital Universitario La Paz.Spain Revista Española de Anestesiología y Reaminación (English Edition)Rev Esp Anestegiol Reamin (Eng Ed) 2024; DOI: 10.1016/j.redare.2024.03.007 AbstractElectrical impedance tomography (EIT) is a new method of monitoring non-invasive mechanical ventilation, at the bedside and useful in critically ill patients. It allows lung monitoring of ventilation

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A Comprehensive Review of Inhaled Nitric Oxide Therapy: Current Trends, Challenges, and Future Directions

Divyanshi Kaplish, Jayant D. Vagha, Revat J. Meshram, Sham LohiyaJawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & ResearchIndia CureusCureus 2024; 16:DOI: 10.7759/cureus.53558 AbstractThis comprehensive review explores the multifaceted landscape of inhaled nitric oxide (iNO) therapy, tracing its historical evolution, mechanisms of action, clinical applications, challenges, and future directions. The nitric oxide signaling pathway,

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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension

Zhe Wang, Yi-Xuan Zhang, Jun-Zhuo Shi, Yi Yan, Lu-Ling Zhao, Jie-Jian Kou, Yang-Yang He, Xin-Mei Xie, Si-Jin Zhang, Xiao-Bin PangHuaihe Hospital of Henan University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Guangdong Provincial People’s Hospital and Southern Medical University.China Hypertension ResearchHypertens Res 2024; DOI: 10.1038/s41440-024-01607-9 Abstractm6A (N6‑methyladenosine)

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Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

A. Dushani, C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. SchwarzBoston Children’s Hospital and Harvard Medical School. Indiana University School of Medicine.United States CellsCells 2024; 13:DOI: 10.3390/cells13030244 AbstractPulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations

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Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension

Michael W. Cookson, John P. KinsellaUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado.United States Clinics in PerinatologyClin Perinatol 2024; 51: 95-111DOI: 10.1016/j.clp.2023.11.001 AbstractPivotal trials investigating the use of inhaled nitric oxide (iNO) in the 1990s led to approval by the Food and Drug Administration in 1999. Inhaled nitric oxide is the only approved

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Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, “Precision-Medicine” Approach

Satyan Lakshminrusimha, Steven H. AbmanUniversity of California, Davis Children’s Hospital. University of Colorado Anschutz Medical Campus.United States Clinics in PerinatologyClin Perinatol 2024; 51: 77-94DOI: 10.1016/j.clp.2023.12.003 AbstractOxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clinical

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Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. RottkampUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2024; 51: 271-289DOI: 10.1016/j.clp.2023.10.002 AbstractLong-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN

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