Review Articles Concerning Pulmonary Vascular Disease

Evolving Role of Three-Dimensional Echocardiography for Right Ventricle Volume Analysis in Pediatric Heart Disease: Literature Review and Clinical Applications

Alessandra M. Ferraro, David M. Harrild, Andrew J. Powell, Philip T. Levy, Gerald R. MarxBoston Children’s Hospital and Harvard Medical School. Sapienza University of Rome. United States and Italy Journal of the American Society of EchocardiographyJ Am Soc Echocardiogr 2024;DOI: 10.1016/j.echo.2024.03.001 AbstractAccurate knowledge of right ventricle (RV) volumes and ejection fraction is fundamental to providing optimal […]

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Review of electrical impedance tomography in the pediatric patient

S. Cabezudo Ballesteros, P. Sanabria Carretero, F. Reinoso BarberoHospital Universitario La Paz.Spain Revista Española de Anestesiología y Reaminación (English Edition)Rev Esp Anestegiol Reamin (Eng Ed) 2024; DOI: 10.1016/j.redare.2024.03.007 AbstractElectrical impedance tomography (EIT) is a new method of monitoring non-invasive mechanical ventilation, at the bedside and useful in critically ill patients. It allows lung monitoring of ventilation

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A Comprehensive Review of Inhaled Nitric Oxide Therapy: Current Trends, Challenges, and Future Directions

Divyanshi Kaplish, Jayant D. Vagha, Revat J. Meshram, Sham LohiyaJawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & ResearchIndia CureusCureus 2024; 16:DOI: 10.7759/cureus.53558 AbstractThis comprehensive review explores the multifaceted landscape of inhaled nitric oxide (iNO) therapy, tracing its historical evolution, mechanisms of action, clinical applications, challenges, and future directions. The nitric oxide signaling pathway,

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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension

Zhe Wang, Yi-Xuan Zhang, Jun-Zhuo Shi, Yi Yan, Lu-Ling Zhao, Jie-Jian Kou, Yang-Yang He, Xin-Mei Xie, Si-Jin Zhang, Xiao-Bin PangHuaihe Hospital of Henan University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Guangdong Provincial People’s Hospital and Southern Medical University.China Hypertension ResearchHypertens Res 2024; DOI: 10.1038/s41440-024-01607-9 Abstractm6A (N6‑methyladenosine)

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Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

A. Dushani, C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. SchwarzBoston Children’s Hospital and Harvard Medical School. Indiana University School of Medicine.United States CellsCells 2024; 13:DOI: 10.3390/cells13030244 AbstractPulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations

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Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension

Michael W. Cookson, John P. KinsellaUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado.United States Clinics in PerinatologyClin Perinatol 2024; 51: 95-111DOI: 10.1016/j.clp.2023.11.001 AbstractPivotal trials investigating the use of inhaled nitric oxide (iNO) in the 1990s led to approval by the Food and Drug Administration in 1999. Inhaled nitric oxide is the only approved

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Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, “Precision-Medicine” Approach

Satyan Lakshminrusimha, Steven H. AbmanUniversity of California, Davis Children’s Hospital. University of Colorado Anschutz Medical Campus.United States Clinics in PerinatologyClin Perinatol 2024; 51: 77-94DOI: 10.1016/j.clp.2023.12.003 AbstractOxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clinical

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Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. RottkampUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2024; 51: 271-289DOI: 10.1016/j.clp.2023.10.002 AbstractLong-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN

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Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review

Kristen Coletti, K. Taylor Wild, Elizabeth E. Foglia, Suzan Cochius-den Otter, Haresh KirpalaniChildren’s Hospital of Philadelphia and University of Pennsylvania. Erasmus MC University Medical Center.United States and Netherlands Clinics in PerinatologyClin Perinatol 2024; 51: 253-269DOI: 10.1016/j.clp.2023.11.009 AbstractInhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn.

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Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings

Prathik Bandiya, Rajeshwari Madappa, Ajay Raghav JoshiSouth Hospital Complex and Dharmaram College Post. SIGMA Hospital. India Clinics in PerinatologyClin Perinatol 2024; 51: 237-252DOI: 10.1016/j.clp.2023.11.002 AbstractPersistent Pulmonary Hypertension of the Newborn (PPHN) is more common in low and middle income countries (LMICs) due to high incidence of sepsis, perinatal asphyxia and meconium aspiration syndrome. Presence of hypoxic

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