Review Articles Concerning Pulmonary Vascular Disease

Arteriovenous Malformations-Current Understanding of the Pathogenesis with Implications for Treatment

Katharina Schimmel, Khadem Ali, Serena Y. Tan, Joyce Teng, Huy M. Do, Gary K. Steinberg, David A. Stevenson, Edda SpiekerkoetterStanford University. Lucile Packard Children’s Hospital. United States International Journal of Molecular SciencesInt J Mol Sci 2021; 22: DOI: 10.3390/ijms22169037 AbstractArteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an […]

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Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children

Bibhuti B. DasUniversity of Mississippi Medical Center.United States ChildrenChildren 2025; 12: DOI: 10.3390/children12040476 AbstractPulmonary hypertension (PH) is a progressive disorder characterized by obstructive changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance (PVR), right ventricular (RV) strain, and eventual RV failure (RVF). Despite advancements in medical therapy, PH remains associated with significant morbidity and

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Pulmonary vein stenosis: future optimism

Patcharapong Suntharos, Marin Satawiriya, Lourdes R. PrietoCleveland Clinic Children’s Hospital. Ramathibodi Hospital, Mahidol University. Nicklaus Children’s Hospital.United States and Thailand Current Opinion in CardiologyCurr Opin Cardiol 2025; DOI: 10.1097/HCO.0000000000001217 AbstractPurpose of review: Pulmonary vein stenosis (PVS) is a rare disease with high morbidity and mortality. Prevention of restenosis remains challenging. This review will highlight recent advances in

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Pulmonary hypertension in pediatrics: from clinical suspicion to management

Julie Wacker, Maurice BeghettiGeneva University Hospitals. Switzerland European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06099-4 AbstractPediatric pulmonary hypertension differs from adult pulmonary hypertension in many ways, including multifactorial etiologies and comorbidities that can impact diagnosis, response to therapy, and outcome. The main etiologies of pediatric PH are idiopathic pulmonary arterial hypertension (PAH), PAH associated

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Risk stratification in Eisenmenger syndrome

Estibaliz Valdeolmillos, Athenaïs Boucly, Marc Humbert, Olivier Sitbon, Laurent Savale, David Montani, Jérôme Le Pavec, Elie Fadel, Magalie Ladouceur, Emmanuelle Fournier, Gregoire Albenque, Bastien Provost, Clément Batteux, Alain Fraisse, Michael A. Gatzoulis, Aleksander Kempny, Sebastien HascoëtHôpital Marie Lannelongue, les hôpitaux Paris Saint-Joseph et Marie Lannelongue and Université Paris-Saclay. Hôpitaux Universitaires de Genève. Royal Brompton Hospital.

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Summary for Clinicians: Clinical Practice Guideline on Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy

Ryan D. Coleman, Sarah P. Cohen, Pirooz Eghtesady, R. Mark Grady, David L. S. Morales. Don Hayes Jr., Joseph K. Ruminjo, W. Graham CarlosBaylor College of Medicine. Nationwide Children’s Hospital. Washington University School of Medicine. Cincinnati Children’s Hospital Medical Center. Indiana University School of Medicine. United States Annals of the American Thoracic SocietyAnn Am Thorac

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Respiratory Support Strategies for Surgical Neonates: A Review

Piero Alberti, Niyi Ade-Ajayi, Anne GreenoughKing’s College London.United Kingdom ChildrenChildren 2025; 12: DOI: 10.3390/children12030273 AbstractNeonates with congenital conditions which require surgical management frequently experience respiratory distress. This review discusses the management of pulmonary complications and the respiratory support strategies for four conditions: oesophageal atresia-tracheoesophageal fistula (OA-TOF), congenital diaphragmatic hernia (CDH), congenital lung malformations (CLM), and anterior

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Omphalocele and Associated Anomalies: Exploring Pulmonary Development and Genetic Correlations-A Literature Review

Dina Al Namat, Romulus Adrian Ros, Razan Al Namat, Elena Hanganu, Andrei Ivan, Delia Hînganu, Ancut Lupu, Marius Valeriu HînganuUniversity of Medicine and Pharmacy “Grigore T. Popa”. “Saint Mary” Emergency Children HospitalRomania DiagnosticsDiagnostics 2025; 15: DOI: 10.3390/diagnostics15060675 AbstractOmphalocele is a rare congenital abdominal wall defect, occurring in approximately 3.38 per 10,000 pregnancies. It is characterized by

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Contemporary treatment of right ventricular failure

Bibhuti B. Das, Shashi RajUniversity of Mississippi Medical Center. Narayana Health.United States and India Journal of Heart and Lung Transplantation OpenJHLT Open 2025; 7: DOI: 10.1016/j.jhlto.2024.100203 AbstractRight ventricular failure (RVF) is a clinical syndrome resulting from structural and functional changes in the right ventricle (RV), leading to inadequate blood flow to the pulmonary circulation and elevated

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Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome

Isabel De Brouchoven, Juan Lorand, Léon Bofferding, Arthur Sorlin, An Van Damme, Olivier DanhaiveSaint-Luc University Hospital,. Luxembourg Hospital Center. Laboratoire National de Santé. University of California San Francisco.Belgium, Luxembourg and United States Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1475143 AbstractIntroduction: Rare pathogenic variants in the PTPN11, KRAS, SOS1 and RAF1 genes are the main molecular causes of Noonan syndrome (NS).

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