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Targeted Therapies for Neonatal Pulmonary Hypertension: Beyond Nitric Oxide

Jeanne Carroll, Rohit Rao, Robin H. SteinhornUniversity of California, San Diego and Rady Children’s Hospital. United States Clinics in PerinatologyClin Perinatol 2024; 51: 113-126DOI: 10.1016/j.clp.2023.11.008 AbstractPulmonary hypertension in the neonatal population can be acute or chronic and carries significant risk for morbidity and mortality. It can be idiopathic but more often is associated with comorbid pulmonary […]

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Pulmonary Vascular Regulation in the Fetal and Transitional Lung

Hannah Holmes, Brahmdeep S. Saini, Olivia J. Moir, Jack R. T. Darby, Janna L. Morrison, Liqun Sun, Mike SeedHospital for Sick Children and University of Toronto. University of South Australia. Canada and Australia Clinics in PerinatologyClin Perinatol 2024; 51: 1-19DOI: 10.1016/j.clp.2023.11.003 AbstractFetal lungs have fewer and smaller arteries with higher pulmonary vascular resistance (PVR) than a

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Recurrent Syncope Unveiling Pulmonary Hypertension Secondary to Pulmonary Artery Thrombi in a Pediatric Patient

Dina AlkhateebAltamimi, Karim Khalidi, Rima Khasawneh, Abdulhadi Alzaben, Khaled SalaymehAl Khalidi Hospital. Yarmouk University. Jordan CureusCureus 2024; 16DOI: 10.7759/cureus.51812 AbstractWe present a case of a nine-year-old female patient who presented with recurrent syncope and was ultimately diagnosed with pulmonary hypertension (PH) secondary to pulmonary artery thrombi in the context of anti-phospholipid syndrome (APS). Extensive investigations including

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Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling

Ling Tang, Xiao Zhou, Aili Guo, Lizhang Han, Silin PanJinan Central Hospital. Central Hosptial. Qilu Hospital. Qingdao Women and Children’s Hospital. Shandong University.China Cardiovascular ToxicologyCardiovasc Toxicol 2024;DOI: 10.1007/s12012-023-09822-5 AbstractHigh expression of the zinc finger X-chromosomal protein (ZFX) correlates with proliferation, aggressiveness, and development in many types of cancers. In the current report, we investigated the efficacy

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Guidelines and Recommendations for Targeted Neonatal Echocardiography and Cardiac Point-of-Care Ultrasound in the Neonatal Intensive Care Unit: An Update from the American Society of Echocardiography

Patrick J. McNamara, Amish Jain, Afif El-Khuffash, Regan Giesinger, Dany Weisz, Lindsey Freud, Philip T. Levy, Shazia Bhombal, Willemde Boode, Tina Leone, Bernadette Richards, Yogen Singh, Jennifer M. Acevedo, John Simpson, Shahab Noori, Wyman W. LaiUniversity of Iowa. University of Toronto. Royal College of Surgeons in Ireland. Boston Children’s Hospital and Harvard Medical School. Emory

Guidelines and Recommendations for Targeted Neonatal Echocardiography and Cardiac Point-of-Care Ultrasound in the Neonatal Intensive Care Unit: An Update from the American Society of Echocardiography Read More »

Stent Implantation Across the Atrial Flow Regulator Device

Enrico Piccinelli, Fausto Frazzetto, Mara Pilati, Gianfranco ButeraBambino Gesù Hospital and Research Institute. Politecnico di Torino. Università del Piemonte Orientale. Italy Pediatric CardiologyPediatr Cardiol 2024;DOI: 10.1007/s00246-024-03405-z AbstractThe Atrial Flow Regulator (AFR) is a self-expandable double-disc device with a central fenestration, intended to maintain a calibrated communication across the interatrial septum. We reported for the first time

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Challenges in clinical identification of right ventricular dysfunction in preterm infants with persistent pulmonary hypertension of the newborn

Faith Zhua, Caio Barbosa de Oliveira, Nada Mohsen, Ashraf Kharrat, Poorva Deshpande, Luc Mertens, Amish JainMount Sinai Hospital, Hospital for Sick Children and University of Toronto.Canada Early Human DevelopmentEarly Hum Dev 2024; 190DOI: 10.1016/j.earlhumdev.2024.105942 AbstractBackground: Right ventricular dysfunction, typically qualitatively diagnosed (Q-RVd) in preterm infants, requires echocardiography which is not always acutely available. We aimed to identify

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Survival of Infants With Severe Congenital Kidney Disease After ECMO and Kidney Support Therapy

Kara Short, Martha McBride, ScottAnderson, Rachel Miller, Daryl Ingram, Carl Coghill, Brian Sims, David AskenaziChildren’s of Alabama and University of Alabama at Birmingham.United States PediatricsPediatrics 2024; DOI: 10.1542/peds.2023-062717 AbstractCongenital kidney failure not only affects the homeostatic functions of the kidney, but also affects neonatal respiratory integrity. Until recently, extracorporeal membrane oxygenation (ECMO) support was not used

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Survival outcomes for congenital heart disease from Southern Malaysia: results from a congenital heart disease registry

Mohd Nizam Mat Bah, Aina Salwa Kasim, Mohd Hanafi Sapian, Emieliyuza Yusnita AliasHospital Sultanah Aminah.Malaysia Archives of Diseases in ChildhoodArch Dis Child 2024;DOI: 10.1136/archdischild-2023-326622 AbstractObjective: Limited population-based studies are available on the survival of congenital heart disease (CHD) from lower- and middle-income countries. Therefore, we evaluated the survival from birth until 15 years and associated factors for

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Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Marissa D. Pokharel, Alejandro Garcia-Flores, David Marciano, Maria C. Franco, Jeffrey R. Fineman, Saurabh Aggarwal, Ting Wang, Stephen M. BlackFlorida International University. University of California, San Francisco.United States Redox BiologyRedox Biol 2024; 70:DOI: 10.1016/j.redox.2024.103049 AbstractOnce thought of in terms of bioenergetics, mitochondria are now widely accepted as both the orchestrator of cellular health and the gatekeeper

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