Fresh (PHresh). Less than 1-2 years since publication

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells

Manivannan Yegambaram, Marissa D. Pokharel, Xutong Sun, Qing Lu, Jamie Soto, Saurabh Aggarwal, Emin Maltepe, Jeffery R. Fineman, Ting Wang, Stephen M. BlackFlorida International University. University of California San Francisco. United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26083815 AbstractIt is well-established that mitochondrial dysfunction plays a critical role in the […]

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension

Sunil K. Sati, Ujala Rana, Chintamani Joshi, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04098-7 AbstractBackground: Impaired angiogenesis contributes to increased pulmonary vascular resistance in persistent pulmonary hypertension of the newborn (PPHN). Notch signaling, critical to lung angiogenesis, is modulated by micro-RNAs (miR). RNA sequencing of pulmonary arterial endothelial cells

Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension Read More »

Persistent pulmonary hypertension of the newborn infant (PPHN) due to premature closure of the ductus arteriosus (DA)

Ayevbekpen Grace Okoye, Adrita Khawash, Mahesh Nanjundappa, Matthew Jones, Anne GreenoughKings College Hospital NHS Foundation Trust. Evelina Children’s Hospital and Guys and St Thomas Hospital. United Kingdom Case Reports in Perinatal MedicineCase Rep Perinat Med 2025; 13: DOI: 10.1515/crpm-2024-0001 AbstractObjectives: To describe the course of an infant with persistent pulmonary hypertension of the newborn (PPHN) secondary to

Persistent pulmonary hypertension of the newborn infant (PPHN) due to premature closure of the ductus arteriosus (DA) Read More »

Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children

Bibhuti B. DasUniversity of Mississippi Medical Center.United States ChildrenChildren 2025; 12: DOI: 10.3390/children12040476 AbstractPulmonary hypertension (PH) is a progressive disorder characterized by obstructive changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance (PVR), right ventricular (RV) strain, and eventual RV failure (RVF). Despite advancements in medical therapy, PH remains associated with significant morbidity and

Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children Read More »

Real-Time Assessment of Pulmonary Blood Flow in Pulmonary Vein Stenosis Using the Fluoroscopic Flow Calculator

Yuval Barak-Corren, Mudit Gupta, Yoav Dori, Jessica Tang, Christopher L. Smith, Jonathan J. Rome, Matthew J. Gillespie, Matthew A. Jolley, Michael L. O’Byrne, Ryan CallahanChildren’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania.United States Journal of the Society for Cardiovascular Angiography and InterventionsJ Soc Cardiovasc Angiogr Interv 2025; 4:DOI: 10.1016/j.jscai.2025.102639 AbstractBackground: Restenosis

Real-Time Assessment of Pulmonary Blood Flow in Pulmonary Vein Stenosis Using the Fluoroscopic Flow Calculator Read More »

Pulmonary vein stenosis: future optimism

Patcharapong Suntharos, Marin Satawiriya, Lourdes R. PrietoCleveland Clinic Children’s Hospital. Ramathibodi Hospital, Mahidol University. Nicklaus Children’s Hospital.United States and Thailand Current Opinion in CardiologyCurr Opin Cardiol 2025; DOI: 10.1097/HCO.0000000000001217 AbstractPurpose of review: Pulmonary vein stenosis (PVS) is a rare disease with high morbidity and mortality. Prevention of restenosis remains challenging. This review will highlight recent advances in

Pulmonary vein stenosis: future optimism Read More »

Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management

Samuel F. Schaeffer, Bwaar Omer, Akshaya Vachhaarajani, Chaitanya PanchangamUniversity of Missouri.United States NeoreviewsNeoreviews 2025; 26: e316-e327DOI: 10.1542/neo.26-5-013 AbstractScreening for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) was recommended by the American Thoracic Society in 2015. However, the definition of BPD has since changed. This review summarizes the current definition of BPD, the recommendations and

Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management Read More »

Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways

Katharina Nubbemeyer, Julia Krabbe, Svenja Böll, Anna Michely, Sebastian Kalverkamp, Jan Spillner, Christian MartinRWTH Aachen University. Ruhr University Bochum. Germany BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13040856 AbstractBackground/Objectives: Pulmonary hypertension is a progressive disease leading to right heart failure. One treatment strategy is to induce vasodilation via the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway. There

Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways Read More »

Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes

Renping Mao, Weiwei Ruan, Jianming Zhu, Li Li, Haiyan Jiang, Yanhong LiAffiliated Women and Children’s Hospital of Ningbo University.China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1511892 AbstractBackground: Congenital hepatic hemangioma with arteriovenous fistula (HHAVF) is a rare condition in newborns that may manifest as respiratory distress, pulmonary hypertension, and heart failure shortly after birth. This report

Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes Read More »

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