Fresh (PHresh). Less than 1-2 years since publication

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Yifei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, Kentaro Iwasawa, Min Shi, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Debora I. Sinner, Xingchen Liu, Ko Chih Lin, Cheng-Lun Na, Keishi Kishimoto, Min-Chi Yang, Sushila Maharjan, Jason Tchieu, Jeffrey A. Whitsett, Yu Shrike Zhang, Kyle W. McCracken, Robbert J. Rottier, Darrell N. Kotton, […]

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Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O’Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. PalmerOhio State University. University of Maryland School of Medicine. University of California San Diego. University of Colorado, Anschutz Medical Campus. United States Biotechnology and BioengineeringBiotechnol Bioeng 2025; DOI: 10.1002/bit.70012 AbstractPlasma transferrin (Tf)

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Development of late pulmonary hypertension after antenatal inflammation in experimental bronchopulmonary dysplasia

Paula Dias Maia, Gregory Seedorf, Tania Gonzalez, Elisa Bye, Benjamin S. Frank, Erica W. Mandell, Steven H. AbmanUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado. Unoted States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04223-6 AbstractBackground: Antenatal inflammation due to chorioamnionitis is strongly associated with the development of bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension (BPD-PH)

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Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study

Cynthia Kleppinger, Dunbar Ivy, Norman Stockbridge, Angela Bates, Stephanie Handler, Usha S. Krishnan, Mary P. Mullen, Delphine Yung, Rachel K. Hopper, Nidhy P. Varghese, Jef Fineman, Eric D. Austin, Catherine M. Avitabile, Grace Freire, Jennifer Clark, Haihao SunUnited States Food and Drug Administration. University of Colorado. Stollery Children’s Hospital. Medical College of Wisconsin. Columbia University

Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study Read More »

Echo-Derived Right Ventricular Strain Identifies Pulmonary Hypertension in Pediatric Ventricular Assist Device Patients

Ryan S. Bishop, Tam T. Doan, Claudia Lara, Lindsay F. Eilers, Hari P. Tunuguntla, Joseph A. Spinner, Ricardo H. Pignatelli, Anitha Parthiban, James C. WilkinsonTexas Children’s Hospital and Baylor College of Medicine.United States American Society for Artificial Internal OrgansASAIO 2025; DOI: 10.1097/MAT.0000000000002489 AbstractIdentifying pulmonary hypertension in pediatric patients with continuous-flow ventricular assist device (cf-VAD) remains challenging,

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TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension

M. L. Garcia-Hernandez, Javier Rangel-Moreno, Qingfu Xu, Ye Jin Jeong, Soumyaroop Bhattacharya, Ravi Misra, Stacey Duemmel, Ke Yuan, Benjamin D. KormanUniversity of Rochester Medical Center. Boston Children’s Hospital.United States Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.174456 AbstractThe pathobiology of pulmonary hypertension (PH) is complex and multiple cell types contribute to disease pathogenesis. We sought

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Anxiety and Depression Screening of Youth in Pediatric Pulmonary Hypertension Clinic: A Multi-Center, Cross-Sectional Study

Claire Parker, Elise Whalen, Michael A. Smith, Jasmine Becerra, Leah Stevens, Catherine M. Avitabile, Anna Brown, Michelle Cash, Emma Olson Jackson, Julia McSweeney, Kathleen Miller‐Reed, Janette T. Reyes, Cathy Sheppard, Mary P. Mullen, Pulmonary Hypertension Network (PPHNet)University of California, San Francisco and Benioff Children’s Hospital. Texas Children’s Hospital. University of Pennsylvania Perelman School of Medicine

Anxiety and Depression Screening of Youth in Pediatric Pulmonary Hypertension Clinic: A Multi-Center, Cross-Sectional Study Read More »

The Use of Vasodilator Therapy in Fontan Patients: A Single-Centre Experience

Alessia Faccini, Martina Avesani, Roberta Biffanti, Elettra Pomiato, Domenico Sirico, Alice Pozza, Alessia Cerutti, Elena Reffo, Biagio Castaldi, Giovanni Di SalvoUniversity Hospital Padua.Italy ChildrenChildren 2025; 12:DOI: 10.3390/children12060751 AbstractBackground: The aim of this study was to describe our centre experience in the use of pulmonary vasodilator therapy in Fontan patients.Methods: We retrospectively enrolled patients that underwent Fontan operation between

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Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States

Anne M. Sescleifer, Charbel Chidiac, Zane J. Hellmann, Katherine M. McDermott, Alejandro V. Garcia, Daniel S. Rhee, Mark B. Slidell, Daniel G. Solomon, Shauen M. KunisakiJohns Hopkins University School of Medicine. Yale School of Medicine.United States Journal of Pediatric SurgeryJ Pediatr Surg 2025; DOI: 10.1016/j.jpedsurg.2025.162423 AbstractPurpose: For over a decade, there has been evidence suggesting a lack

Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States Read More »

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring

Ze‑wen Chen, Yi‑fan Li, Hai‑long Qiu, Wen Xie, Tian‑yu Chen, Yong Zhang, Ji‑mei Chen, Jian Zhuang, Shu‑sheng WenGuangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) and Southern Medical University. China Current Medical ScienceCurr Med Sci 2025; DOI: 10.1007/s11596-025-00074-8 AbstractObjective: Electronic cigarettes (ECs) differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling. Pulmonary hypertension (PH),

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring Read More »

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