Fresh (PHresh). Less than 1-2 years since publication

p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia

Lisandra Vila Ellis, Jonathan D. Bywaters, Amanda Ceas, Yun Liu, Jennifer M. S. Sucre, Jichao ChenNorthwestern University.  Vanderbilt University Medical Center. Cincinnati Children’s Hospital Medical Center.United States Journal of Clinical Investigation InsightsJCI Insights 2025;DOI: 10.1172/jci.insight.182880 AbstractBronchopulmonary dysplasia (BPD), a prevalent and chronic lung disease affecting premature newborns, results in vascular rarefaction and alveolar simplification. Although the […]

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Hereditary hemorrhagic telangiectasia in pediatrics: descriptive study in a specialized unit

Magalí Squitín Tasende, Nicolás Guerrero Serravalle, Lucía G. Pérez, Ana Braslavsky, Marcelo SerraHospital Italiano de Buenos Aires and Universidad Hospital Italiano.Argentina Archivos Argentinos de PediatríaArch Argent Pediatr 2025; DOI: 10.5546/aap.2025-10661.eng AbstractIntroduction. Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia characterized by bleeding telangiectasias and arteriovenous malformations (AVMs) in the brain, lungs, liver, and gastrointestinal

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Neighborhood Child Opportunity Index and Outcomes in Pediatric Pulmonary Hypertension

Jai Krishan Khurana, Stuart Lipsitz, Diana L. Geisser, Katie M. Moynihan, Mary P. MullenBoston Children’s Hospital, Brigham and Women’s Hospital and Harvard Medical School.United States Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03981-8 AbstractThe role of social determinants of health (SDoH) in pediatric pulmonary hypertension (PH) outcomes are inadequately characterized. We hypothesized outcomes differ according to SDoH with

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Transcatheter Versus Surgical Correction of Superior Sinus Venosus Defects: Comparison of the Outcomes and Late Complications

Puthiyedath Thejaswi, Kothandam Sivakumar, Farheen Qureshi, Pramod Sagar. Sreeja Pavithran, Ravi AgarwalMadras Medical Mission.India Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03975-6 AbstractTranscatheter correction (TC) of sinus venosus defects (SVD) is an emerging alternative to surgical correction (SC). Superior vena caval (SVC) or right upper pulmonary vein (RUPV) stenosis and sick sinus syndrome are complications of SC. This

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Severe pertussis complicated by pulmonary hypertension in a Moroccan infant: a case report

Mehdi Belhakim, Zineb El jaouhahri, Aicha Boudar, Loubna Benaddi, Karima Naanani, Rachida Habbal, Abdelaziz ChlilekUniversity Hospital Ibn Rochd, Children’s Hospital and University Hassan II.Morocco Journal of Medical Case ReportsJ Med Case Rep 2025; 19: DOI: 10.1186/s13256-024-04898-1 AbstractBackground: Despite high vaccination coverage among children, pertussis continues to pose a significant public health challenge in Morocco. Mortality primarily affects

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Liver and systemic hemodynamics in cirrhotic children.

Roberto Tambucci, Xavier Stephenne, Aniss Channaoui, Catherine de MagnéeCliniques Universitaires Saint-Luc and UCLouvain. Belgium World Journal of HepatologyWorld J Hepatol 2025; 17: DOI: 10.4254/wjh.v17.i7.103179 AbstractPortal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population. During cirrhosis progression, circulation becomes hyperdynamic, with cardiac, pulmonary and renal consequences. Cirrhotic

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Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2-5 weeks of age

Katarina Övermo Tydén, Kerstin Magnusson, Carmen Mesas Burgos, Baldvin Jonsson, Felicia NordenstamKarolinska Institutet and Karolinska University Hospital.Sweden Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1598695 AbstractIntroduction: Neonates with congenital diaphragmatic hernia (CDH) often present with pulmonary hypertension and various forms of cardiac dysfunction, affecting right or left ventricle or both. Although pulmonary hypertension typically improves over time,

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Pharmacologic Management of Segmental Pulmonary Hypertension in Children After Unifocalization and Pulmonary Artery Reconstruction: Initial Experience

Julian E. Cameron, Doff B. McElhinney, Esther Liu, Rachel K. Hopper, Ritu Asija, Manchula Navaratnam, Frank L. Hanley, Jeffrey A. FeinsteinLucile Salter Packard Children’s Hospital and Stanford University School of Medicine. Children’s Hospital Los Angeles and Keck School of Medicine University of Southern California.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70134 AbstractSegmental pulmonary hypertension (PH)

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Case Report: A case of severe pulmonary hypertension combined with FBN1 mutation associated geleophysic dysplasia

Ze-yang Chen, Yuan Cao, Jie Yang, Xue-hua He, Li-ping Liu, Yong-hua YuanQingdao University School of Medicine. Hunan Provincial People’s Hospital and First Affiliated Hospital of Hunan Normal University.China Frontiers in PediatricFront Pediatr 2025; DOI: 10.3389/fped.2025.1642390 AbstractBackground: FBN1 gene mutation-associated geleophysic dysplasia (GD) leads to the formation of complex and refractory pulmonary hypertension (PH) through a multifactorial combination

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Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Martina U. Muckenthaler, Thomas Geiser, Mona Lichtblau, Silvia UlrichUniversity of Zürich. University of Heidelberg. University of Berne.Switzerland and Germany Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70142 AbstractIron deficiency (ID) is prevalent in pulmonary hypertension(PH), but there is no consensus on ID definition and its possible correlation to prognostic markers.

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