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Inhaled Nanoparticulate Systems: Composition, Manufacture and Aerosol Delivery

Heidi M. Manour, Priya Muralidharan, Don Hayes Jr.University of Arizona. Ohio State University College of Medicine. United States Journal of Aerosol Medicine and Pulmonary Drug DeliveryJ Aerosol Med Pulm Drug Deliv 2024; 37: 202-218 DOI: 10.1089/jamp.2024.29117.mk AbstractAn increasing growth in nanotechnology is evident from the growing number of products approved in the past decade. Nanotechnology can […]

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The evolution of clinical trials for pediatric pulmonary hypertension: are the needs of patients and their caregivers being met?

Julie Wacker, Raphael Joye, Leon Genecand, Frederic Lador, Maurice BeghettiUniversity Hospitals of Geneva. Switzerland Expert Review of Clinical PharmacologyExpert Rev Clin Pharmacol 2024; DOI: 10.1080/17512433.2024.2396119 AbstractIntroduction: Pediatric pulmonary hypertension is a rare condition. Survival remains poor in the current management era. There is a lack of data regarding the medical management of pediatric pulmonary hypertension and most

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Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

Ekaterina Legchenko, Philippe Chouvarine, Fatimunnisa Qadri, Edgar Specker, Marc Nazaré, Radoslaw Wesolowski, Susann Matthes, Michael Bader, Georg HansmannHannover Medical School. Max-Delbrück-Center for Molecular Medicine. Trypto Therapeutics GmbH. German Center for Cardiovascular Research. Charité Universitätsmedizin Berlin. University of Lübeck. Friedrich-Alexander-University Erlangen-Nürnberg. Germany Journal of the Amerian College of Cardiology Basic to Translational ScienceJACC Basi Transl Sci

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression Read More »

Right Ventricular Strain With 4-Dimensional Computed Tomography Identifies Pulmonary Hypertension in Adults With Repaired Tetralogy of Fallot

Yamato Shimomiya, Michinobu Nagao, Tomohito Kogure, Seiji Asagai, Akihiro Inoue, Atsushi Yamamoto, Shuji Sakai, Kei Inai, Takashi Shirasaka, Tsukasa Kojima, Hidetake YabuuchiKyushu University. Tokyo Women’s Medical University. Japan Circulation JournalCirc J 2024; DOI: 10.1253/circj.CJ-24-0386 AbstractBackground: This study evaluated right ventricular (RV) volume, strain, and morphology using cardiac 4-dimensional computed tomography (4D-CT) to detect pulmonary hypertension (PH) in

Right Ventricular Strain With 4-Dimensional Computed Tomography Identifies Pulmonary Hypertension in Adults With Repaired Tetralogy of Fallot Read More »

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Christopher J. Rhodes, Adam Brownstein, Lloyd L. Liang, Laila Aryan, Min Li, Arjun Vadgama, Zeyneb Kurt, Tae-Hwi Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, Frédéric Perros, David Montani, Nicholas W. Morrell, Florent Soubrier, Martin R.

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension Read More »

Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook

Daniel I. McLennan, Jennifer R. Maldonado, Susan R. Foerster, Stephanie S. Handler, John F. LaDisa Jr., Todd M. Gudausky, Roger J. Guillory IIChildren’s Wisconsin and the Medical College of Wisconsin. Marquette University.United States Frontiers in Cardiovascular MedicineFront Cardiovas Med 2024; DOI: 10.3389/fcvm.2024.1410305 AbstractThe past five years have yielded impressive advancements in fully absorbable metal stent technology.

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Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Read More »

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α Read More »

In situ relief of postrepair pulmonary venous obstruction using the endocardial anchoring technique

Yusuke Yamamoto, Sho Akiyama, Kentaro Hotoda, Mio Noma, Shuhei Yamaguchi, Hiroki Nagamine, Jun Maeda, Yukihiro YoshimuraTokyo Metropolitan Children’s Medical Center. Japan Journal of Thoracic and Cardiovascular Surgery TechniquesJTCVS Tech 2024; 26: 96-99DOI: 10.1016/j.xjtc.2024.04.009 AbstractOutcomes of the conventional repair for total anomalous pulmonary venous return (TAPVR) remain suboptimal mainly due to the occurrence of progressive pulmonary venous

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Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models

Megan Griffiths, Catherine E. Simpson, Jun Yang, Dhananjay Vaidya, Melanie K. Nies, Stephanie Brandal, Rachel Damico, Paul Hassoun, D. Dunbar Ivy, Eric D. Austin, Michael W. Pauciulo, Katie A. Lutz, Lisa J. Martin, Erika B. Rosenzweig, Raymond L. Benza, William C. Nichols, Cedric Manlhiot, Allen D. EverettJohns Hopkins University. University of Texas Southwestern. Children’s Hospital

Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models Read More »

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