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Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function

Pilar Blanco-Lobo, Paula Gilabert-Prieto, Beatriz de Felipe, David Moreno-Fuentes, Paloma Guisado Hernández, Ana Ortiz-Ramírez, Anna Mensa-Vilaró, Juan I. Aróstegui, Natalia Palmou, Valle Velasco Gonzalez, Ángela Deyà Martinez, Jan Ramakers, José Ivorra-Cortés, Cristina Roca, Elisa Cordero, Inmaculada Guillen, Nicolás Valerdiz Menéndez, José Manuel Lucena, Mirella Gaboli, Peter Olbrich, Olaf NethIBiS/Hospital Universitario Virgen del Rocío and CSIC/Universidad […]

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Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage Read More »

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Norbert Dera, Łukasz Minarowski, Łukasz Osinski, Anna Doboszynska, Sławomir Szajda, Alina MinarowskaMedical University of Gdańsk. Center of Postgraduate Medical Education. Warsaw Institute of Women’s Health. Medical University of Bialystok. University Teaching Hospital. Regional Specialist Hospital in Olsztyn. University of Warmia and Mazury in Olsztyn. University of Warmia and Mazury. Children’s University Hospital in

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review Read More »

A rare case of isolated unilateral pulmonary vein atresia presenting as interstitial lung disease in a young adult

Arnav Shandil, Mansi Verma, Sushma Makhaik, Sumala KapilaIndira Gandhi Medical CollegeIndia Journal of Cardiovascular and Thoracic ResearchJ Cardiovasc Thorac Res 2025; 17: 212-214DOI: 10.34172/jcvtr.025.33139 AbstractUnilateral pulmonary vein atresia is an unusual congenital cardiovascular abnormality. It occurs due to failure of incorporation of pulmonary veins into the left atrium. It is usually diagnosed in childhood and diagnosis

A rare case of isolated unilateral pulmonary vein atresia presenting as interstitial lung disease in a young adult Read More »

Bronchopulmonary Dysplasia Definitions As Predictors of Early Childhood Pulmonary Function

Brianna C. Aoyama, Sharon A. McGrath-Morrow, Joseph M. CollacoJohns Hopkins University. University of Pennsylvania Perelman School of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71402 AbstractObjective: To assess the clinical utility and predictive ability of three commonly used definitions of bronchopulmonary dysplasia (BPD) (2001 NHLBI, 2018 NICHD, 2019 NRN) in forecasting lung function outcomes in children

Bronchopulmonary Dysplasia Definitions As Predictors of Early Childhood Pulmonary Function Read More »

The relation between Down syndrome and co-occurring conditions in children and young adults: A population-based cohort in Denmark, 1977-2016

Cheng Yin, Chuanjie Deng, Catherine M. Crespi, Sari Bar, Chandra D. Carey, M. Elizabeth Brickner, Eugenia Chock, Erin C. Schafer, Igor Barjaktarevic, Kosuke Inoue, Johnni Hansen, Julia E. HeckUniversity of North Texas. University of California, Los Angeles. University of Texas Southwestern Medical Center. University of Pittsburgh. Yale School of Medicine. Graduate School of Medicine of

The relation between Down syndrome and co-occurring conditions in children and young adults: A population-based cohort in Denmark, 1977-2016 Read More »

Incidence and risk factors of pulmonary hypertension in neonates with congenital diaphragmatic hernia: a systematic review and meta-analysis

Rebeca Lopes Figueira, Fabian Doktor, Nazgol Moheimani, Giuseppe Lauriti, Jessie Lu, Giuseppe Speziale, Augusto ZaniHospital for Sick Children. Washington University School of Medicine. University of Leipzig Medical Center. “G. d’Annunzio” University of Chieti-Pescara, “Spirito Santo” Hospital of Pescara. Canada, United States, Germany and Italy Pediatric Surgery InternationalPediatr Surg Int 2025; 42: DOI: 10.1007/s00383-025-06247-9 AbstractPurpose: Pulmonary hypertension secondary

Incidence and risk factors of pulmonary hypertension in neonates with congenital diaphragmatic hernia: a systematic review and meta-analysis Read More »

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications Read More »

Secondary pulmonary hypertension in an adult patient with Ebstein anomaly post-atrial septal defect closure; can it be reversible? A case report

Ahmed Kheiwa, Vandad Saadat, Joseph Chung, Stephen Nageotte, Anees RazzoukLoma Linda University Medical Center. European Heart Journal Case ReportsEur Heart J Case Rep 2025; 9: DOI: 10.1093/ehjcr/ytaf527 AbstractBackground: Pulmonary hypertension is often a difficult to diagnose condition, in particular in younger population of patients. Early diagnosis and treatment of this condition is crucial to prevent further morbidity

Secondary pulmonary hypertension in an adult patient with Ebstein anomaly post-atrial septal defect closure; can it be reversible? A case report Read More »

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat

Bingbing Ye, Danyan Su, Yuqin Huang, Dongli Liu, Yanyun Huang, Suyuan Qin, Cheng Chen, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Clinical and Experimental HypertensionClin Exp Hypertens 2025; 47: DOI: 10.1080/10641963.2025.2583193 AbstractThis study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat Read More »

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