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GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation

Ruoxuan Jiang, Liuyi Li, Yuhang Luo, Wen Wang, Xiaoya Zeng, Cheng Qian, Chen Gong, Jianlong ShenSecond Affiliated Hospital of Anhui Medical University. First Affiliated Hospital of Anhui Medical University. China International ImmunopharmacologyInt Immunopharmacol 2026; DOI: 10.1016/j.intimp.2026.116394 AbstractPulmonary arterial hypertension (PAH) is a fatal disease marked by pulmonary vascular remodeling. Although endothelial dysfunction and immune cell infiltration […]

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Predicting pulmonary hypertension in infants with bronchopulmonary dysplasia

Henry P. Foote, Minghui Sun, Benjamin Alan Goldstein, Kevin D. Hill, Rachel G. Greenberg, Samuel J. Gentle, Kanecia O. Zimmerman, Rishikesan Kameleswaran, Veeral N. Tolia, Matthew M. Laughon, Wesley Jackson, Christoph P. HornikDuke University Medical Center and Duke University. Yale University School of Medicine. Baylor University Medical Center. University of North Carolina. United States Journal

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Results of a pulmonary hypertension screening program for premature infants with bronchopulmonary dysplasia

Ramya Ramachandra, Alisa Arunamata, Amanda Moy, Michael C. Tracy, Yinyao Ji, Derek Boothroyd, Rachel K. HopperStanford University School of Medicine and Lucile Packard Children’s Hospital.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02580-6 AbstractObjective: Premature infants with bronchopulmonary dysplasia (BPD) are at risk for pulmonary hypertension (PH). We sought to evaluate outcomes of a PH screening protocol.Study

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Jinlong Liu, Xiafeng Yu, Jiwen Xiong, Yi Yan, Yanjun Sun, Yumin Zhong, Hao ZhangShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China Frontiers in Bioengineering and BiotechnologyFront Bioeng Biotechnol 2026; 13: DOI: 10.3389/fbioe.2025.1697468 AbstractObjectives: Reverse Potts shunt is a promising yet high-risk therapy for pediatric pulmonary arterial hypertension. Postoperative hemodynamics is critically influenced by

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A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited BMPR2 Sheep

Sanjeev A. Datar, Nicholas Werry, Austin R. Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar A. Gonzales Viera, Thomas F. Bishop, Tara Urbano, Bret R. McNabb, Eric D. Austin, Jeffery R. Fineman, and Alison L. Van EenennaamUniversity

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The First 1000 Days: Maternal Nutrient Intake-A Window of Opportunity for Pulmonary Hypertension-A Narrative Review

Alina-Costina Luca, Solange Tamara Rosu, Cosmin Diaconescu, Dana Elena Mîndru, Cristina Gavrilovici, Adriana Vizireanu, Viorel Tarcă, Eduard Vasile Rosu, Elena TarcăGrigore T. Popa University of Medicine and Pharmacy. Apollonia University. Romania NutrientsNutrients 2026; 18: DOI: 10.3390/nu18030424 AbstractThe first 1000 days of life, starting from conception to a child’s second birthday, constitute a pivotal period for fetal

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Cardiac Magnetic Resonance Findings and Their Association with Clinical Outcomes in Pediatric Pulmonary Arterial Hypertension: An Exploratory Study

Meryem Beyazal, Merter Keceli, Oguzhan Dogan, Ibrahim EceChildren Hospital and Ankara Bilkent City Hospital.Turkey Journal of Clinical MedicineJ Clin Med 2026; 15: DOI: 10.3390/jcm15031107 AbstractBackground: Cardiac magnetic resonance [CMR] is a non-invasive tool to assess ventricular function in pediatric pulmonary arterial hypertension [PAH]. However, CMR parameters in children remain underexplored. Methods: Thirty-six children with PAH were prospectively

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Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries

Keiichi Hirono, Keiko Uchida, Taku Ishii, Hidekazu Ishida, Shinichi Takatsuki, Hiroyuki Fukushima, Kei Inai, Susumu Hosokawa, Reina Ishizaki, Hirofumi Sawada, Naofumi F. Sumitomo, Ayako Chida-Nagai, Yuichi Ishikawa, Hirohiko Motoki, Atsushi Yao, Shigetoyo Kogaki, Hiroyuki Yamagishi, Shozaburo DoiToyama University Hospital. Tokyo Medical University. Institute of Science Tokyo. Osaka University Graduate School of Medicine. Toho University, Omori

Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries Read More »

Development of a Robust, Rapid and Reliable Tandem Mass Spectrometry Method for the Measurement of Sildenafil, Bosentan and their Major Metabolites

Mohammad Ahmad Bik, Duygu Eryavuz, Onmaz, Karem Mazin Kamil Gharab, Fadime Karaman, Sedat Abusoglu, Abdullah Sivrikaya, Ali UnluSelcuk University. Mustansiriyah University.Turkey and Iraq Indian Journal of Clinical BiochemistryIndian J Clin Biochem 2026; 41: 113-119DOI: 10.1007/s12291-024-01215-x AbstractPulmonary arterial hypertension (PAH) is a lethal, progressive disease with a complex pathogenesis. Bosentan, a dual endothelin receptor antagonist, and sildenafil,

Development of a Robust, Rapid and Reliable Tandem Mass Spectrometry Method for the Measurement of Sildenafil, Bosentan and their Major Metabolites Read More »

Burden and outcomes of cardiovascular and pulmonary complications in adolescents and adults with sickle cell disease: a systematic review and meta-analysis

Natasha Kaweme, Sahar Buttress, Arthemon Nguweneza, Cynthia Phiri, Takudzwa Mtisi, Pauline Sambo, Gwendoline Kandawasvika, Hamakwa Mantina, Patience Kuona, Catherine Chunda-LiyokaUniversity Teaching Hospitals. University of Cape Town. University of Zimbabwe.Zambia, South Africa and Zimbabwe Systematic ReviewsSyst Rev 2026;DOI: 10.1186/s13643-026-03077-1 AbstractBackground: Sickle cell disease (SCD) is a genetic blood disorder associated with chronic cardiovascular and pulmonary complications, including pulmonary

Burden and outcomes of cardiovascular and pulmonary complications in adolescents and adults with sickle cell disease: a systematic review and meta-analysis Read More »

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