Filed (PHiled). Greater than 1-2 years since publication

A rare cause of newborn central cyanosis

Anna Waldoch, Robert Sabiniewicz, Joanna KwiatkowskaMedical University in Gdansk.Poland EchocardiographyEchocardiography 2020; 37: 1524-1525DOI: 10.1111/echo.14809 AbstractPulmonary arteriovenous malformations are rare congenital vascular anomalies. They are usually associated with congenital hemorrhagic hemangioma. The hemodynamic effect of fistulas depends on their size, as well as the location. The most common manifestations include central cyanosis, ischemic stroke, murmur over the

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Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice

Yi Jin, Bernadette Chen, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00202.2024 AbstractBronchopulmonary dysplasia (BPD) is a common chronic lung disease in pediatrics. Neonatal mice placed in hyperoxia (85% oxygen, HYP) develop lung injury

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice Read More »

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells

Manivannan Yegambaram, Marissa D. Pokharel, Xutong Sun, Qing Lu, Jamie Soto, Saurabh Aggarwal, Emin Maltepe, Jeffery R. Fineman, Ting Wang, Stephen M. BlackFlorida International University. University of California San Francisco. United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26083815 AbstractIt is well-established that mitochondrial dysfunction plays a critical role in the

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

Congenital portosystemic shunts: diagnosis and treatment

Stéphanie Franchi-Abella, Emmanuel Gonzales, Oanez Ackermann, Sophie Banchereau, Daniéle Pariente, Florent Guérin, International Registry of Congenital Poertosystemic Shunt MembersHôpital Bicêtre, Hôpitaux Universitaire Paris-Sud and Assistance Publique Hôpitaux de Paris. National Reference Centre for Rare Pediatric Liver Diseases and Filfoie. University Paris -Sud. France Abdominal RadiologyAbd Radiol 2018; 43: 2023-2036DOI: 10.1007/s00261-018-1619-8 AbstractCongenital portosystemic shunts (CPSS) are rare

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Transcatheter Hepatic Conduit-Azygous Vein Connection Reduces Pulmonary Arteriovenous Malformations in a Cyanotic Fontan Patient

Kanishka Ratnayaka, Zhenglun A. Wei, Justin R. Ryan, Caitlin M. Heyden, Hari K. Narayan, Timothy C. Slesnick, Robert J. Lederman, John W. Moore, Ajit P. Yoganathan, Howaida G. El-SaidRady Children’s Hospital and University of California-San Diego. National Heart, Lung, and Blood Institute. University of Massachusetts Lowell. Children’s Healthcare of Atlanta, Georgia Institute of Technology and

Transcatheter Hepatic Conduit-Azygous Vein Connection Reduces Pulmonary Arteriovenous Malformations in a Cyanotic Fontan Patient Read More »

Pulmonary Complications in Patients With Fontan Circulation: JACC Review Topic of the Week

Ali Abdulkarim, Shawn Shaji, Mahmud Elfituri, Megan Gunsaulus, Muhammad A. Zafar, Ali N. Zaidi, Robert H. Pass, Brian Feingold, Geoffrey Kurland, Jacqueline Kreutzer, Rod Ghassemzadeh, Bryan Goldstein, Shawn West, Tarek AlsaiedIcahn School of Medicine at Mount Sinai. University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh and University of Pittsburgh School of Medicine. University of

Pulmonary Complications in Patients With Fontan Circulation: JACC Review Topic of the Week Read More »

Longitudinal Assessment of Curaçao Criteria in Children with Hereditary Hemorrhagic Telangiectasia

Mordechai Pollak, Dvir Gatt, Michelle Shaw, Sheryl L. Hewko, Anthony Lamanna, Sara Santos, Felix RatjenHospital for Sick Children. Ruth Rappaport Children’s Hospital. Canada and Israel Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113665 AbstractObjective: To assess the utility of the Curaçao criteria by age over time in children with hereditary hemorrhagic telangiectasia (HHT).Study design: This was a single-center, retrospective

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A Congenital Portosystemic Shunt in a Child With Heterotaxy, Situs Inversus, Polysplenia, and Interrupted Inferior Vena Cava With Azygous Continuation

Victoria Carvajal, Saigopala Reddy, Vani Gopalareddy, Adrienne Bean, Gonzalo WallisLevine Children’s Hospital. University of North Carolina Chapel Hill Medical School. United States American College of Gastroenterology Case Reports JournalACG Case Rep J 2023; DOI: 10.14309/crj.0000000000001201 AbstractCongenital portosystemic shunts are rare vascular malformations in which portal venous blood from the intestines and spleen bypasses the liver and

A Congenital Portosystemic Shunt in a Child With Heterotaxy, Situs Inversus, Polysplenia, and Interrupted Inferior Vena Cava With Azygous Continuation Read More »

Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension

Sunil K. Sati, Ujala Rana, Chintamani Joshi, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04098-7 AbstractBackground: Impaired angiogenesis contributes to increased pulmonary vascular resistance in persistent pulmonary hypertension of the newborn (PPHN). Notch signaling, critical to lung angiogenesis, is modulated by micro-RNAs (miR). RNA sequencing of pulmonary arterial endothelial cells

Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension Read More »

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