Filed (PHiled). Greater than 1-2 years since publication

BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension

Iona Cuthbertson, Nicholas W. Morrel, Paola CarusoUniversity of Cambridge School of Clinical MedicineUnited Kingdom Circulation ResearchCirc Res 2023; 132(1):109-126DOI: 10.1161/CIRCRESAHA.122.321554 AbstractPulmonary arterial hypertension forms the first and most severe of the 5 categories of pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of peripheral pulmonary arteries, caused by the excessive proliferation of vascular wall cells, […]

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Pulmonary hypertension due to high cardiac output

Kanza N. Qaiser, Sandeep Sahay, Arriano R. TonelliCleveland Clinic. Houston Methodist Hospital.United States Respiratory MedicineRespir Med 2023; DOI: 10.1016/j.rmed.2022.107034 AbstractPulmonary hypertension (PH) is usually associated with a normal or decreased cardiac output (CO). Less commonly, PH can occur in the context of a hyperdynamic circulation, characterized by high CO (>8 L/min) and/or cardiac index ≥4 L/min/m2 in

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Right ventriculo-pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension

Toshitaka Nakaya, Hiroshi Ohira, Takahiro Sato, Taku Watanabe, Masaharu Nishimura, Noriko Oyama-Manabe, Masaru Kato, Yoichi M. Ito and Ichizo TsujinoHokkaido University Hospital. The Institute of Statistical Mathematics.Japan Pulmonary CirculationPulm Circ 2020; 10: DOI: 10.1177/2045894020957223 AbstractRight ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right

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Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Jennifer Barnes, Peter G. Linde, Janethe de Oliveira Pena, David B. BadeschPULSAR Trial Investigators.France, United States, United Kingdom,

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Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias1, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. BadeschHôpital Bicêtre, Assistance Publique-Hôpitaux de Paris. University of Michigan Health System. Imperial

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension

Paul J. Critser, Debra Boyer, Gary A. Visner, Shane L. Collins, Mary P. MullenHarvard University and Boston Children’s Hospital.United States Pediatric TransplantationPediatr Transplant 2022; 26: e14236DOI: 10.1111/petr.14236 AbstractBackground: Lung transplantation is a therapeutic option for end-stage pediatric pulmonary hypertension (PH). Right ventricular (RV) recovery post-lung transplant in children with PH has not been well-described, and questions persist

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Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension

Paul J. Critser, Patrick D. Evers, Kristin Schneider, Russel Hirsch, Michael D. Taylor, Jason C. Woods, Sean M. LangUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center.United States Journal of EchocardiographyJ Echocardiogr 2022; 20: 24-32DOI: 10.1007/s12574-021-00545-6 AbstractBackground: Right ventricular function and afterload are associated with clinical outcomes in pulmonary hypertension (PH). MRI-derived interventricular septal curvature has been

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Prognostic value of longitudinal vasoreactivity in pediatric pulmonary hypertension

Patrick D. Evers, Patrick Quinn, Paul J. Critser, Benjamin S. Frank, Laurie B. ArmsbyOregon Health Sciences University. University of Cininnati. University of Colorado.United States Pulmonary CirculationPulm Circ 2022; 12: e12152DOI: 10.1002/pul2.12152 AbstractUpon diagnosis of pulmonary hypertension in pediatrics, standard practice often involves acute vasoreactivity testing (AVT) in the cardiac catheterization laboratory. However, the importance of repeated

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Pulmonary Vascular Sequelae of Palliated Single Ventricle Circulation: Arteriovenous Malformations and Aortopulmonary Collaterals

Andrew D. Spearman, Salil GindeMedical College of WisconsinUnited States Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2023; 9: 309DOI: 10.3390/jcdd9090309 AbstractChildren and adults with single ventricle congenital heart disease (CHD) develop many sequelae during staged surgical palliation. Universal pulmonary vascular sequelae in this patient population include two inter-related but distinct complications: pulmonary arteriovenous malformations

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