Environmental Factors Associated with Pulmonary Vascular Disease

Metagenomic Analysis of Gut Microbiome of Persistent Pulmonary Hypertension of the Newborn

Linli Han, Chuyang Lin, Yue Lan, Yimin Hua, Jinlin Wu, Zhenxin Fan, Yifei LiWest China Second University Hospital and Sichuan University. China Cardiovascular ToxicologyCardiovasc Toxicol 2024; DOI: 10.1007/s12012-024-09949-z AbstractPersistent pulmonary hypertension of the newborn (PPHN) is one of the most common diseases in the neonatal intensive care unit which severely affects neonatal survival. Gut microbes play […]

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The Role of Early Child Nutrition in Pulmonary Hypertension – A Narrative Review

Alina-Costina Luca, Cristina Stoica, Cosmin Diaconescu, Elena T. Tarcă, Solange Tamara Ros, Lăcrămioara Ionela Butnariu, Bogdan Aurelian Stana, Bogdan Gafton, Antoanela Curici, Eduard Vasile Ros, Dana Elena Mîndru“Grigore T. Popa” University of Medicine and Pharmacy. Emergency Hospital for Children “Sfanta Maria”. ”Carol Davila” University of Medicine and Pharmacy.Romania ChildrenChildren 2024; 11: DOI: 10.3390/children11111307 AbstractPulmonary hypertension is

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Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease

Jiahui Xie, Xiaoyu Zhang, Liming Cheng, Yao Deng, Haobo Ren, Minghua Mu, Liang Zhao, Chunjie Mu, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University. First hospital of Kunming. Kunming Children’s Hospital.China Microbiology SpectrumMicrobiol Spectr 2024; DOI: 10.1128/spectrum.01808-24 AbstractDysregulation of immune and inflammatory cells around blood vessels and metabolic dysfunction are key mechanisms in the development of pulmonary arterial hypertension (PAH). The homeostasis of the human microbiome

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Clinical profile and thiamine transporter gene (SLC19A2 and SLC19A3) variations in infants with thiamine-responsive pulmonary hypertension and acute respiratory infection

Swathi Shenoy, Vijaya Kumar Deekshit, Swathi Sunil Rao, Prathibha Shankar Ashwini, Rathika Damodara ShenoyNITTE University Center for Science Education and Research. Doctor’s Hospital. American University of Antigua College of Medicine.India, Antigua and Barbuda Journal of Tropical PediatricsJ Trop Pediatr 2024; DOI: 10.1093/tropej/fmae030 AbstractMaternal thiamine deficiency is prevalent in low- and middle-income countries. Thiamine-responsive pulmonary hypertension (TRPHTN)

Clinical profile and thiamine transporter gene (SLC19A2 and SLC19A3) variations in infants with thiamine-responsive pulmonary hypertension and acute respiratory infection Read More »

The prognostic value of prognostic nutritional index in postoperative onset of PAH in children with isolated VSD: a prospective cohort study based on propensity score matching analysis

Zeying Zhang, Jing Su, Chenyang Li, Shirui Cao, Chao Sun, Qiuzhen Lin, Haiyan Luo, Zhenghui Xiao, Yunbin Xiao, Qiming LiuSecond Xiangya Hospital of Central South University. Hunan Children’s Hospital. China Frontiers in PediatricsFront Pediatr 2024; 12:DOI: 10.3389/fped.2024.1292786 AbstractBackground: The mechanism of pulmonary arterial hypertension (PAH) after surgery/intervention for isolated venticlular septal defect (VSD) in children is unknown.

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Chylothorax related to acute SARS-CoV-2 infection in a patient with Noonan syndrome with prior uncomplicated cardiac surgeries

Lubaina Ehsan, Jessica A. Thoe, John J. Parent, Joseph D. FakhouryWestern Michigan University Homer Stryker, M.D. School of Medicine and Bronson Children’s Hospital. Indiana University School of Medicine.United States Cardiology in the YoungCardiol Young 2024; 34: 448-451DOI: 10.1017/S1047951123004171 AbstractSARS-CoV-2 is a novel coronavirus that has rarely been associated with chylothorax. Patients with Noonan syndrome are at

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GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

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Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders

Haoran Shen, Rui Zheng, Mulong Du, David C. ChristianiNanjing Medical University. Harvard T.H. Chan School of Public Health. Massachusetts General Hospital.China and United States ThoraxThorax 2024; DOI: 10.1136/thorax-2023-221302 AbstractBackground: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the

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An Unusual Etiology of Severe Right Heart Failure Deserving of Wider Recognition

Woosun Kang, Yu Zong, Dhruvil Ashishkumar Patel, Tushar Mishra, Luis AfonsoWayne State University. University of Chicago.United States Journal of the American College of Cardiology Case ReportsJACC Case Rep 2024; 29:DOI: 10.1016/j.jaccas.2024.102222 AbstractA previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of

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Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

A. Dushani, C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. SchwarzBoston Children’s Hospital and Harvard Medical School. Indiana University School of Medicine.United States CellsCells 2024; 13:DOI: 10.3390/cells13030244 AbstractPulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations

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