Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

QT dispersion and T wave peak-to-end in pediatric patients with sickle cell disease

Hanaa H. Eldash, Rana Mostafa, Heba A. BorayekFayoum University.Egypt Journal of ElectrocardiologyJ Electrocardiol 2025; DOI: 10.1016/j.jelectrocard.2025.154059 AbstractAim: The aim of the study was to detect cardiac repolarization changes and the risk of arrhythmias in children with sickle cell disease (SCD) and sickle thalassemia using echocardiography and electrocardiography (ECG).Methods: This is an observational case-control study that compared 20 patients […]

QT dispersion and T wave peak-to-end in pediatric patients with sickle cell disease Read More »

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O’Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. PalmerOhio State University. University of Maryland School of Medicine. University of California San Diego. University of Colorado, Anschutz Medical Campus. United States Biotechnology and BioengineeringBiotechnol Bioeng 2025; DOI: 10.1002/bit.70012 AbstractPlasma transferrin (Tf)

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice Read More »

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial

Dalia A. Gomaa, Sahar M. El‑Haggar, Mohamed R. El‑Shanshory, Osama El‑Razaky, Dalia R. El‑AffyTanta University. Egypt Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00701-w AbstractBackground: Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial Read More »

Scurvy, all the faces you can see: our experience and review of the literature

Fabio Toscano, Giuseppina Zirilli, Simone Foti Randazzese, Mariagrazia Carlino, Romina Gallizzi, Malgorzata Wasniewska, Mariella ValenziseUniversity of Messina. Magna Graecia University of Catanzaro.Italy Italian Journal of PediatricsItal J Pediatr 2025; 51: DOI: 10.1186/s13052-025-02014-7 AbstractBackground: In the recent past an incremental incidence of scurvy has been reported in the pediatric population, especially in children with neuropsychiatric disorders and a

Scurvy, all the faces you can see: our experience and review of the literature Read More »

Vasculopathy among children and adolescents with sickle cell disease: the crosstalk with annexin A1, vitamin D, and myocardial iron overload

Mohsen Saleh ElAlfy, Eman Abdel Rahman Ismail, Sara Mostafa Makkeyah, Ahmed Samir, Dina Husseiny Salama, Nanis Mohammed Salah Eldin, Dina Mohamed Fathy ElMaghraby, Nada Ayman Gad, Marwa Fath Ahmed Ali, Fatma Soliman El-Sayed EbeidAin Shams University. National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority. Minia UniversityEgypt Expert Review of HematologyExpert Rev Hematol

Vasculopathy among children and adolescents with sickle cell disease: the crosstalk with annexin A1, vitamin D, and myocardial iron overload Read More »

Eliglustat and cardiac comorbidities in Gaucher disease: a pharmacogenomic approach to safety and efficacy

Noor Ul Ain, Armaan Saith, Audrey Ruan, Ruhua Yang, Aaron Burton, Pramod K. MistryYale School of Medicine and Yale New Haven Hospital.United States Frontiers in MedicineFront Med 2025; 12: DOI: 10.3389/fmed.2025.1535099 AbstractIntroduction: Gaucher disease (GD), a lysosomal storage disorder, results from the accumulation of glycosphingolipids due to deficient lysosomal glucocerebrosidase activity. This pathological accumulation triggers immune activation,

Eliglustat and cardiac comorbidities in Gaucher disease: a pharmacogenomic approach to safety and efficacy Read More »

Genetic Variants and Clinical Features of Patients With Glycogen Storage Disease Type Ib

Yu Xia, Yu Sun, Taozi Du, Chengkai Sun, Ying Xu, Wensong Ge, Lili Liang, Ruifang Wang, Manqing Sun, Bing Xiao, Wenjuan QiuXinhua Hospital, Ruijin Hospital and Shanghai Jiao Tong University. China Journal of the American Medical Association Network OpenJAMA Netw Open 2025; 8: DOI: 10.1001/jamanetworkopen.2024.61888 AbstractImportance: Glycogen storage disease type Ib (GSDIb) is a rare metabolic disorder

Genetic Variants and Clinical Features of Patients With Glycogen Storage Disease Type Ib Read More »

Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy

Stine Andersen, Jesper Vandborg Bjerre, Karin Baekgaard, Lars Idorn, Mads Jønsson AndersenAarhus University Hospital and Aarhus University. Copenhagen University Hospital.Denmark Pediatric Blood and CancerPediatr Blood Cancer 2025; DOI: 10.1002/pbc.31623 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Diseasec

Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy Read More »

Case Report: severe pulmonary hypertension in a child with micronutrient deficiency

Laure Pache-Wannaz, Cristiana Voicu, Laurence Boillat, Nicole SekarskiLausanne University Hospital and University of Lausanne.Switzerland Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1478889 AbstractWe describe the rare case of a previously healthy seven year-old boy, with an acute clinical onset of severe pulmonary hypertension. He recovered rapidly after vitamin supplementation. Patient history showed a highly selective food

Case Report: severe pulmonary hypertension in a child with micronutrient deficiency Read More »

Targeting Lung Heme Iron by Aerosol Hemopexin Administration in Sickle Cell Disease Pulmonary Hypertension

Melissa Lucero, Christina Lisk, Francesca Cendali, Delaney Swindle, Saini Setua, Kiruphagaran Thangaraju, David I. Pak, Quinton O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Nishant Rana, Saqib Khan, Natalie Westover, Pavel Davizon Castillo, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Andre F. Palmer, Angelo D’Alessandro, Paul W. Buelher, David C. IrwinUniversity of Colorado,

Targeting Lung Heme Iron by Aerosol Hemopexin Administration in Sickle Cell Disease Pulmonary Hypertension Read More »

Scroll to Top