Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

Long-Term Complications of Sickle Cell Disease

Luisanna M. Sánchez, Ajibike Lapite, Alicia Chang, Titilope A. FasipeIndiana Hemophilia and Thrombosis Center. Baylor College of Medicine and exas Children’s Hospital. University of Texas at Austin and Dell Children’s Hospital. United States Pediatrics in ReviewPediatr Rev 2026; 47: 394-403DOI: 10.1542/pir.2024-006446 AbstractSCD is a prevalent genetic disorder marked by chronic complications that impact quality of life […]

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Disease-related complications and risk factors in hemoglobin H disease in a Thai multicenter registry

Nattiya Teawtrakul, Duantida Songdej, Chattree Hantaweepant, Adisak Tantiworawit, Sasinee Hantrakool, Pornpun Sripornsawan, Pacharapan Surapolchai, Supanun Lauhasurayotin, Kitti Torcharus, Pranee Sutcharitchan, Noppacharn Uaprasert, Krissana Panrong, Napat Laoaroon, Patcharee Komvilaisak, Panachai Silpsamrit, Arunotai Meekaewkunchorn, Bunchoo Pongtanakul, Pimlak Charoenkwan & Red Blood Cell Disorders Study GroupSrinagarind Hospital and Khon Kaen University. Ramathibodi Hospital, Siriraj Hospital and Mahidol University.

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A Life Without Lemons: A Case of Severe Pulmonary Arterial Hypertension Secondary to Vitamin C Deficiency in a Child With Autism Spectrum Disorder

Beau Redwood, Simon Erickson, Lily Loughman, Zoe VettenPerth Children’s Hospital. Genetic Services of Western Australia.Australia Journal of Pediatrics and Child HealthJ Pediatr Child Health 2026; DOI: 10.1111/jpc.70448 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh

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Sickle cell disease-associated pulmonary hypertension: an integrated framework linking pathologies, mechanisms, and clinical phenotypes

Florence Vallelian, Dominik J. Schaer, Benoit Lechartier, Paul W. Buehler, David C. IrwinUniversity of Zurich. Lausanne University Hospital and University of Lausanne. University of Maryland. Anschutz Medical Campus School of Medicine and University of Colorado. Switzerland and United States eBioMedicineeBioMedicine 2026; DOI: 10.1016/j.ebiom.2026.106288 AbstractSickle cell disease-associated pulmonary hypertension (SCD-PH) affects approximately 10% of adults with SCD

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Prevalence and Risk Factors for Pulmonary Hypertension in Children with Sickle Cell Disease: A Prospective Observational Study from Central India

Kapil Dev Rabha, Rajkumar Kundavaram, Pooja Soni, Amber Kumar, NarendraKumar Chaudhary, Bhavna DhingraLower Assam Hospital and Research Centre. All India Institute of Medical Sciences.India Indian Journal of PediatricsInd J Pediatr 2026; DOI: 10.1007/s12098-026-06175-z AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders Age Focus: Pediatric Pulmonary Vascular Disease Fresh

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Pulmonary arterial hypertension in infancy: A case series

N. V. Shashikala, K. M. Arun, R. C. Ashwini, Muganagowda PatilBapuji Child Health Institute and Research Centre. India Tropical DoctorTrop Doct 2026;DOI: 10.1177/00494755261451113 AbstractThiamine deficiency is a reversible cause of severe pulmonary arterial hypertension (PAH) in early infancy, particularly among exclusively breastfed infants of mothers consuming polished rice-based diets. This retrospective case series (July 2023-July 2025)

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Pediatric Pulmonary Hypertension: A Systematic Approach

Andrew Corson, Ranjit Philip, Neil Tailor, Abhishek Chakraborty, Kaitlynn Littleford, Grace McCormick, Aaron WalshLe Bonheur Children’s Hospital and University of Tennessee Health Science Center College of Medicine.United States Journal of the American College of Cardiology Case ReportsJACC Case Rep 2026;DOI: 10.1016/j.jaccas.2026.108135 AbstractBackground: Pediatric pulmonary hypertension comprises a variety of etiologies across different age groups, requiring a systematic

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A child with cobalamin C deficiency caused by complex heterozygous variation of c.567dupT and c.80A > G complicated with pulmonary arterial hypertension and hydrocephalus: A case report and literature review

Cui, Xuxia, Zhong, Yajing, Yin, ChongjuanFirst Hospital of Shanxi Medical University.China MedicineMedicine 2026; 105: DOI: 10.1097/MD.0000000000048340 AbstractRationale: Cobalamin C (cblC) deficiency is one of the most common congenital vitamin B12 metabolic abnormalities, and may cause severe neurologic symptoms, gastrointestinal and nephritic symptoms.Patient concerns: A 9-month-old boy presented with a 10-day history of progressive dyspnea and weak cough, accompanied by

A child with cobalamin C deficiency caused by complex heterozygous variation of c.567dupT and c.80A > G complicated with pulmonary arterial hypertension and hydrocephalus: A case report and literature review Read More »

Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible

Tomás Woodgate, Jay Patel, Thomas Day, Brodie Knight, Adriani Spanaki, Alistair Calder, Shahin Moledina, Sadia QuyamGreat Ormond Street Hospital. Royal Hospital for Children. Evelina London Children’s Hospital,United Kingdom PediatricsPediatrics 2026; DOI: 10.1542/peds.2025-073645 AbstractWe report 4 children (aged 3-9 years) with severe pulmonary hypertension (PH) associated with vitamin C deficiency. All presented with either musculoskeletal symptoms or

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A Rare Case of Reversible Pulmonary Hypertension Phenotype in a Child with Scurvy: Aetiologies Insights

Mattia Pasquinucci, Luisa Bonsembiante, Sofia Mezzalira, Martina Locallo, Davide MeneghessoAULSS 7 Pedemontana-San Bassiano Hospital. IRCCS Istituto Giannina Gaslini. University of Padua.Italy ReportsReports 2026; DOI: 10.3390/reports9010044 AbstractBackground and Clinical Significance: Scurvy, caused by chronic vitamin C deficiency, is re-emerging in Western countries, particularly among pediatric patients with highly selective diets. While its musculoskeletal and mucocutaneous manifestations are well-known,

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