Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible

Tomás Woodgate, Jay Patel, Thomas Day, Brodie Knight, Adriani Spanaki, Alistair Calder, Shahin Moledina, Sadia QuyamGreat Ormond Street Hospital. Royal Hospital for Children. Evelina London Children’s Hospital,United Kingdom PediatricsPediatrics 2026; DOI: 10.1542/peds.2025-073645 AbstractWe report 4 children (aged 3-9 years) with severe pulmonary hypertension (PH) associated with vitamin C deficiency. All presented with either musculoskeletal symptoms or […]

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A Rare Case of Reversible Pulmonary Hypertension Phenotype in a Child with Scurvy: Aetiologies Insights

Mattia Pasquinucci, Luisa Bonsembiante, Sofia Mezzalira, Martina Locallo, Davide MeneghessoAULSS 7 Pedemontana-San Bassiano Hospital. IRCCS Istituto Giannina Gaslini. University of Padua.Italy ReportsReports 2026; DOI: 10.3390/reports9010044 AbstractBackground and Clinical Significance: Scurvy, caused by chronic vitamin C deficiency, is re-emerging in Western countries, particularly among pediatric patients with highly selective diets. While its musculoskeletal and mucocutaneous manifestations are well-known,

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The First 1000 Days: Maternal Nutrient Intake-A Window of Opportunity for Pulmonary Hypertension-A Narrative Review

Alina-Costina Luca, Solange Tamara Rosu, Cosmin Diaconescu, Dana Elena Mîndru, Cristina Gavrilovici, Adriana Vizireanu, Viorel Tarcă, Eduard Vasile Rosu, Elena TarcăGrigore T. Popa University of Medicine and Pharmacy. Apollonia University. Romania NutrientsNutrients 2026; 18: DOI: 10.3390/nu18030424 AbstractThe first 1000 days of life, starting from conception to a child’s second birthday, constitute a pivotal period for fetal

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Burden and outcomes of cardiovascular and pulmonary complications in adolescents and adults with sickle cell disease: a systematic review and meta-analysis

Natasha Kaweme, Sahar Buttress, Arthemon Nguweneza, Cynthia Phiri, Takudzwa Mtisi, Pauline Sambo, Gwendoline Kandawasvika, Hamakwa Mantina, Patience Kuona, Catherine Chunda-LiyokaUniversity Teaching Hospitals. University of Cape Town. University of Zimbabwe.Zambia, South Africa and Zimbabwe Systematic ReviewsSyst Rev 2026;DOI: 10.1186/s13643-026-03077-1 AbstractBackground: Sickle cell disease (SCD) is a genetic blood disorder associated with chronic cardiovascular and pulmonary complications, including pulmonary

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Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension

Viranuj Sueblinvong, Sarah S. Chang, Jing Ma, David R. Archer, Solomon Ofori-Acquah, Roy L. Sutliff, Changwon Park, C. Michael Hart, Benjamin T. Kopp, Bum-Yong KangEmory University School of Medicine. Atlanta Veterans Affairs Healthcare System. National Institutes of Health. Louisiana State University Health Science Center. United States CellsCells 2026; 15: DOI: 10.3390/cells15020154 AbstractPulmonary hypertension (PH) causes morbidity

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Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy

Ruxuan He, Jinrong Liu, Xiaolei Tang, Hui Liu, Yuelin Shen, Xioayan Zhang, Huimin Li, Shunying Zhao, Haiming YangBeijing Children’s Hospital and Capital Medical University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital and Seventh People’s Hospital of Xinjiang Uygur Autonomous Region.China Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04720-8 AbstractBackground: Cobalamin C (cblC) deficiency,

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Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. GrahamUniversity of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and

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Reversible pulmonary hypertension in a patient diagnosed with scurvy

Gregory Berra, Léon Genecand, Anais Juillet, Jean-François Deux, Paco Prada, Hajo Müller, Marco Roffi, Maurice BeghettiGeneva University Hospitals. Switzerland British Medical Journal Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2025-266143 AbstractThis case report describes a woman in her late 50s with reversible pulmonary hypertension (PH) due to scurvy, a rare vitamin C (ascorbic acid) deficiency in

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Early Echocardiographic and Serum Biomarkers Predict Thrombotic Microangiopathy, Endotheliopathy, and Survival after Pediatric Hematopoietic Stem Cell Transplant

Michael A. Smith, Zachary Hutchinson, Elizabeth Colglazier, Claire Parker, Christine S. Higham, Jeffrey R. Fineman, Matt S. Zinter, Christopher C. Dvorak, Hythem M. NawaytouUniversity of California, San Francisco. Transplantation and Cellular TherapyTransplant Cell Ther 2025; DOI: 10.1016/j.jtct.2025.11.024 AbstractBackground: Many life-threatening complications of hematopoietic stem cell transplantation (HSCT) develop secondary to endothelial injury and dysfunction, including transplant-associated thrombotic

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Acute Toxicities and Early Outcomes of Tandem Autologous Stem Cell Transplantation in Pediatric High-Risk Neuroblastoma: A Multicenter Study

Zahra Hudda, Aaron Webster, Eric Anderson, Priscila Badia, Rochelle Bagatell, Saleh Bhar, Alan Bidgoli, Karla Boyd, Sonali Chaudhury, Gabriel Salinas Cisneros, John Craddock, Stella M Davies, Ami V. Desai, Lianna Drobatz, Christopher C. Dvorak, Hannah Elkus, Vanessa A. Fabrizio, Jennifer H Foster, Ellen Fraint, Jason L. Freedman, Jorge Galvez, Mark Garcia, Ann Haight, Christine Higham,

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