Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

Macrophages Contribute to Pulmonary Hypertension Associated With Sickle Cell Disease

Christina Lisk, Francesca Cendali, Natalie Westover, Delaney Swindle, Daniel Colon Hidalgo, Caitlin Lewis, Melissa J. Lucero, Nishant K. Rana, Gemlyn George, Saini Setua, Monika Dzieciatkowska, Kathryn Hassel, Christy S. Niemeyer, Kurt Stenmark, Eva Nozik, Angelo D’Alessandro, Paul W. Buehler, David C. IrwinUniversity of Colorado Denver – Anschutz Medical Campus. Children’s Hospital Colorado. University of Maryland

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Addressing micronutrient deficiencies and vitamin metabolism disorders in pediatric pulmonary hypertension: a strategic proposal for low- and middle-income countries

Mattia Pasquinucci, Marco Scaglione, Sofia Mezzalira, Luisa Bonsembiante, Mariaelena Zaffina, Pietro Pogacnik, Sara Bondanza, Ramona Marini, Maria E. Derchi, Davide MeneghessoSan Bassiano Hospital. Hôpital Universitaire Necker-Enfants Malades. University of Padua.  IRCCS Istituto Giannina Gaslini. Università degli Studi Gugliemo Marconi.Italy and France Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1900356 AbstractBackground: Pediatric pulmonary hypertension

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Extracellular Hemoglobin, Hypoxia, and Macrophage-Mediated Pulmonary Vascular Remodeling in Hemolytic Disease

Melissa J. Lucero, Eva Nozik, Kathryn Hassell, David C. Irwin, Paul W. Buehler, Scott K. FergusonUniversity of Colorado Anschutz Medical Campus. University of Maryland. Embry-Riddle Aeronautical University.United States International Journal of Molecular ScienceInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27188170 AbstractPulmonary hypertension (PH) is a well-recognized complication of chronic hemolytic anemias such as sickle cell

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An infant with persistent pulmonary hypertension of the newborn and congenital hypothyroidism

Georgia Eva Fouli, Raghavendra Subba-Rao, Ravindra Bhat, Anne GreenoughKing’s College Hospital. United Kingdom Case Reports in Perinatal MedicineCase Rep Perinat Med 2026; DOI: 10.1515/crpm-2026-0003 AbstractObjectives: We report an infant who presented with persistent pulmonary hypertension of the newborn (PPHN) to highlight this was likely due to congenital hypothyroidism.Case presentation: A male infant born at term presented with respiratory

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The Epidemiology of Pulmonary Hypertension in Sub-Saharan Africa-A Systematic Report

Katarina Zeder, Lanjing Wang, Veranyuy Ngah, Armella Santi, Eric W. Robbins, Ana O. Mocumbi, Judith Namuyonga, Peter Nyasulu, Gabor Kovacs, Marc Humbert, Geoff Strange, Simon Stewart, Guoqing Diao, Bradley A. MaronUniversity of Maryland. Medical University of Graz. George Washington University. Stellenbosch University. University Eduardo Mondlane. Uganda Heart Institute and Makerere University College of Health Sciences.

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Etiologies of Pulmonary Arterial Hypertension in Early Infants: A 4-year Experience from a Tertiary Care Center in Southern India

Ysphaneendra Mallimoggala, Monalisa Biswas, Nitin Thyagaraja, H. Koushik, Krishnananda Nayak, Shrikiran Aroor, Varashree Bolar Suryakanth, Leslie LewisKasturba Medical College of Manipal Academy of Higher Education, Manipal College of Health Professionals and National Institute of Mental Health and Neuro Sciences. India Annals of African MedicineAnn Afr Med 2026; DOI: 10.4103/aam.aam_555_26 AbstractIntroduction: Pulmonary arterial hypertension (PAH) is relatively uncommon

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Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report

Miki Kanai, Hirofumi Tsuru, Takanori Onuki, Shunsuke Nukaga, Shigehito Baba, Masanori Tsukada, Tadaaki Abe, Fujito Numano, Kei Murayama, Akihiko SaitohSaiseikai Niigata Kenoh Kikan Hospital. Niigata University School of Medicine. Juntendo University. Japan Internal MedicineIntern Med 2026; DOI: 10.2169/internalmedicine.7614-26 AbstractPulmonary hypertension (PH) is uncommon in myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) and its hemodynamics are poorly

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Identification of Clinical Sub-Phenotypes of Sickle Cell Disease Using Latent Class Analysis

Shaina M. Willen, Ann M. Brunson, Oyebimpe O. Adesina, Ted WunUniversity of California Davis. United States American Journal of HematologyAm J Hematol 2026; DOI: 10.1002/ajh.70459 AbstractSickle cell disease (SCD), a monogenic disorder, exhibits variable severity due to genetic and environmental modifiers. Prior studies have proposed hemolytic and vaso-occlusive sub-phenotypes based on limited data. We used latent

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Cardiac Remodeling Patterns in Pediatric and Adolescent Patients with Sickle Cell Disease and Their Association with the Genotype and Clinical Severity of the Disease: A Systematic Review

Alam Eldin M. Mustafa, Niemat Mohammed Tahir AliKing Khalid University. University of Kordofan.Saudi Arabia and Sudan HealthcareHealthcare 2026; 14:DOI: 10.3390/healthcare14142180 AbstractBackground: Sickle cell disease (SCD) is the most common inherited blood disorder globally, affecting approximately 300,000 newborns annually. Cardiac remodeling, resulting from chronic anemia, vascular obstruction, and endothelial dysfunction, substantially contributes to morbidity and mortality in patients

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Long-Term Complications of Sickle Cell Disease

Luisanna M. Sánchez, Ajibike Lapite, Alicia Chang, Titilope A. FasipeIndiana Hemophilia and Thrombosis Center. Baylor College of Medicine and exas Children’s Hospital. University of Texas at Austin and Dell Children’s Hospital. United States Pediatrics in ReviewPediatr Rev 2026; 47: 394-403DOI: 10.1542/pir.2024-006446 AbstractSCD is a prevalent genetic disorder marked by chronic complications that impact quality of life

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