Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review

Sagad O.O. Mohamed, Amged Mohammed, Fatima S.K. Salih, Hozifa A.M. Elgadal, Ayman A.A. Elsamany, Mohamed S.K. Salih, Huda M.A. Mustafa, Israa Elawad, Mona G.A. Ahmedkaroum, Safaa G.A. Saeed, Rowa E.A. Ibrahim, Esraa A. Mohamedien, Aya A.H. Babiker, Esraa T. Suliman, Eman O.E. MohamedUniversity of Khartoum. Médecins Sans Frontières. University of Bahri. Ibri Regional Hospital. Harlem […]

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review Read More »

Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review

Alessandra Di Nora, Maria Carla Finocchiaro, Francesco Pizzo, Trobia Gian Luca, Maria Elena Cucuzza, Antonella Di Stefano, Serena Spampinato, Silvia Marino, Martino Ruggieri, Piero PavoneUniversity of Catania. Cannizzaro Emergency Hospital. ARNAS Garibaldi Hospital.Italy Open MedicineOpen Med 2025; DOI: 10.1515/med-2024-1086 AbstractBackground: Vitamin C is a key to many important functions. It stimulates the immune system by protecting humans

Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review Read More »

Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease Read More »

Pediatric Pulmonary Hypertension Associated With Treatment of Myeloproliferative Disorders and Malignant Tumors

Ayako Chida‐Nagai, Yukayo Terashita, Shinsuke Hirabayashi, Hirokuni Yamazawa, Yuko Cho, Atsushi ManabeHokkaido University.Japan Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70165 AbstractPulmonary hypertension (PH) is a severe complication observed in pediatric patients after hematopoietic cell transplantation or chemotherapy. A review of records at Hokkaido University Hospital (2014-2024) identified four cases of PH, each with different etiologies, including

Pediatric Pulmonary Hypertension Associated With Treatment of Myeloproliferative Disorders and Malignant Tumors Read More »

Targeted Proteomic Analysis of Sickle Cell Disease Patients With Elevated Tricuspid Regurgitation Velocity

Varshini Babu, Jane A. Little, Claudia R. Morris, Roberto Machado, Simon Gibbs, Gregory A. Kato, Victor R. Gordeuk, MArk T. Gladwin, Yingze Zhang, Seyed Mehdi NouraieUniversity of Pittsburgh. University of North Carolina at Chapel Hill.  Emory University School of Medicine and Children’s Healthcare of Atlanta. Indiana University. Imperial College London. CSL Behring. University of Illinois

Targeted Proteomic Analysis of Sickle Cell Disease Patients With Elevated Tricuspid Regurgitation Velocity Read More »

Cardiovascular disease in Sickle cell: mechanisms, diagnostics and therapeutic advances

Elio Haroun, Ankit Agrawal, Aro Daniela Arockiam, Joseph El Dahdah, Joseph Kassab, Michael Nakhla, Michel Chedid El Helou, Harsha Sanaka, Ziad Zalaquett, Simrat Kaur, Tiffany Dong, Rabi Hanna, Brian Griffin, Tom Kai Ming WangCleveland Clinic. United States HeartHeart 2025; DOI: 10.1136/heartjnl-2025-325837 AbstractCardiovascular complications are increasingly recognised as a major driver of morbidity and early mortality in patients

Cardiovascular disease in Sickle cell: mechanisms, diagnostics and therapeutic advances Read More »

Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Martina U. Muckenthaler, Thomas Geiser, Mona Lichtblau, Silvia UlrichUniversity of Zürich. University of Heidelberg. University of Berne.Switzerland and Germany Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70142 AbstractIron deficiency (ID) is prevalent in pulmonary hypertension(PH), but there is no consensus on ID definition and its possible correlation to prognostic markers.

Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension Read More »

QT dispersion and T wave peak-to-end in pediatric patients with sickle cell disease

Hanaa H. Eldash, Rana Mostafa, Heba A. BorayekFayoum University.Egypt Journal of ElectrocardiologyJ Electrocardiol 2025; DOI: 10.1016/j.jelectrocard.2025.154059 AbstractAim: The aim of the study was to detect cardiac repolarization changes and the risk of arrhythmias in children with sickle cell disease (SCD) and sickle thalassemia using echocardiography and electrocardiography (ECG).Methods: This is an observational case-control study that compared 20 patients

QT dispersion and T wave peak-to-end in pediatric patients with sickle cell disease Read More »

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O’Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. PalmerOhio State University. University of Maryland School of Medicine. University of California San Diego. University of Colorado, Anschutz Medical Campus. United States Biotechnology and BioengineeringBiotechnol Bioeng 2025; DOI: 10.1002/bit.70012 AbstractPlasma transferrin (Tf)

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice Read More »

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial

Dalia A. Gomaa, Sahar M. El‑Haggar, Mohamed R. El‑Shanshory, Osama El‑Razaky, Dalia R. El‑AffyTanta University. Egypt Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00701-w AbstractBackground: Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial Read More »

Scroll to Top