Class 5. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other Disorders

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension

Viranuj Sueblinvong, Sarah S. Chang, Jing Ma, David R. Archer, Solomon Ofori-Acquah, Roy L. Sutliff, Changwon Park, C. Michael Hart, Benjamin T. Kopp, Bum-Yong KangEmory University School of Medicine. Atlanta Veterans Affairs Healthcare System. National Institutes of Health. Louisiana State University Health Science Center. United States CellsCells 2026; 15: DOI: 10.3390/cells15020154 AbstractPulmonary hypertension (PH) causes morbidity […]

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Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy

Ruxuan He, Jinrong Liu, Xiaolei Tang, Hui Liu, Yuelin Shen, Xioayan Zhang, Huimin Li, Shunying Zhao, Haiming YangBeijing Children’s Hospital and Capital Medical University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital and Seventh People’s Hospital of Xinjiang Uygur Autonomous Region.China Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04720-8 AbstractBackground: Cobalamin C (cblC) deficiency,

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Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. GrahamUniversity of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and

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Reversible pulmonary hypertension in a patient diagnosed with scurvy

Gregory Berra, Léon Genecand, Anais Juillet, Jean-François Deux, Paco Prada, Hajo Müller, Marco Roffi, Maurice BeghettiGeneva University Hospitals. Switzerland British Medical Journal Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2025-266143 AbstractThis case report describes a woman in her late 50s with reversible pulmonary hypertension (PH) due to scurvy, a rare vitamin C (ascorbic acid) deficiency in

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Early Echocardiographic and Serum Biomarkers Predict Thrombotic Microangiopathy, Endotheliopathy, and Survival after Pediatric Hematopoietic Stem Cell Transplant

Michael A. Smith, Zachary Hutchinson, Elizabeth Colglazier, Claire Parker, Christine S. Higham, Jeffrey R. Fineman, Matt S. Zinter, Christopher C. Dvorak, Hythem M. NawaytouUniversity of California, San Francisco. Transplantation and Cellular TherapyTransplant Cell Ther 2025; DOI: 10.1016/j.jtct.2025.11.024 AbstractBackground: Many life-threatening complications of hematopoietic stem cell transplantation (HSCT) develop secondary to endothelial injury and dysfunction, including transplant-associated thrombotic

Early Echocardiographic and Serum Biomarkers Predict Thrombotic Microangiopathy, Endotheliopathy, and Survival after Pediatric Hematopoietic Stem Cell Transplant Read More »

Acute Toxicities and Early Outcomes of Tandem Autologous Stem Cell Transplantation in Pediatric High-Risk Neuroblastoma: A Multicenter Study

Zahra Hudda, Aaron Webster, Eric Anderson, Priscila Badia, Rochelle Bagatell, Saleh Bhar, Alan Bidgoli, Karla Boyd, Sonali Chaudhury, Gabriel Salinas Cisneros, John Craddock, Stella M Davies, Ami V. Desai, Lianna Drobatz, Christopher C. Dvorak, Hannah Elkus, Vanessa A. Fabrizio, Jennifer H Foster, Ellen Fraint, Jason L. Freedman, Jorge Galvez, Mark Garcia, Ann Haight, Christine Higham,

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Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review

Sagad O.O. Mohamed, Amged Mohammed, Fatima S.K. Salih, Hozifa A.M. Elgadal, Ayman A.A. Elsamany, Mohamed S.K. Salih, Huda M.A. Mustafa, Israa Elawad, Mona G.A. Ahmedkaroum, Safaa G.A. Saeed, Rowa E.A. Ibrahim, Esraa A. Mohamedien, Aya A.H. Babiker, Esraa T. Suliman, Eman O.E. MohamedUniversity of Khartoum. Médecins Sans Frontières. University of Bahri. Ibri Regional Hospital. Harlem

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Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review

Alessandra Di Nora, Maria Carla Finocchiaro, Francesco Pizzo, Trobia Gian Luca, Maria Elena Cucuzza, Antonella Di Stefano, Serena Spampinato, Silvia Marino, Martino Ruggieri, Piero PavoneUniversity of Catania. Cannizzaro Emergency Hospital. ARNAS Garibaldi Hospital.Italy Open MedicineOpen Med 2025; DOI: 10.1515/med-2024-1086 AbstractBackground: Vitamin C is a key to many important functions. It stimulates the immune system by protecting humans

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Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

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Pediatric Pulmonary Hypertension Associated With Treatment of Myeloproliferative Disorders and Malignant Tumors

Ayako Chida‐Nagai, Yukayo Terashita, Shinsuke Hirabayashi, Hirokuni Yamazawa, Yuko Cho, Atsushi ManabeHokkaido University.Japan Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70165 AbstractPulmonary hypertension (PH) is a severe complication observed in pediatric patients after hematopoietic cell transplantation or chemotherapy. A review of records at Hokkaido University Hospital (2014-2024) identified four cases of PH, each with different etiologies, including

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