Class 3. Pulmonary Hypertension Associated with Lung Hypoplasia

Mechanical Compression Causes Lung Hypoplasia in Congenital Diaphragmatic Hernia with GATA4 Genetic Variants

Betty Pham, Zhuowei Li, Gidsela Luna, Nicole Talaba, Na Zhang, Giangela M. Stokes, Mark D. Wienjold, Jinhao Xu, Yujuan Su, Rebecca Hernan, Wendy K. Chung, Xin Sun, David J. McCulleyUniversity of California, San Diego and Rady Children’s Hospital. University of Wisconsin-Madison. Boston Children’s Hospital and Harvard Medical School. United States American Journal of Physiology Lung […]

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A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia

Carly E. Byrd, John T. Wren, Suneetha Desiraju, Patrick J. McNamaraJohns Hopkins University School of Medicine. University of Iowa Hospitals and Clinics.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02582-4 AbstractDespite ample research in acute pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH) leading to improved survival, there is a paucity of literature on the

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Initial Hemodynamic Phenotypes and Clinical Trajectory in Congenital Diaphragmatic Hernia: A Pilot Study

John T. Wren Jr., Rachael M. Hyland, Patrick J. McNamaraUniversity of Iowa Healthcare.United States Journal of PediatricsJ Pediatr 2026; DOI: 10.1016/j.jpeds.2026.115044 AbstractObjectives: To define clinically the initial (<24 hour) hemodynamic phenotypes (no/mild pulmonary hypertension [PH], pre-capillary PH, and post-capillary PH) in neonates with congenital diaphragmatic hernia (CDH) by echocardiography, and to assess their relationship with clinical outcomes.Study

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Impact of Hernia Sac in Congenital Diaphragmatic Hernia: Associations with Morbidity and Mortality

Krysta M Sutyak 1, Kylie I Holden 2, Charles Green 3, Matthew T Harting 2, KuoJen Tsao 4, Kouji Nagata 5, Richard Keijzer 6, Marietta Jank 6, Tim Jancelewicz 7, Joseph T Church 8, Pamela A Lally 2, Kevin P Lally 4; For, The Congenital Diaphragmatic Hernia Study Group McGovern Medical School and University of Texas Health Science Center at Houston and Children’s Memorial Hermann Hospital. Kyushu University. University of Manitoba. University of Tennessee Health Science Center. University of

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Liver herniation in congenital diaphragmatic hernia is associated with delayed resolution of pulmonary hypertension

Uthaya Kumaran Kanagaraj, Mimi T.Y. Kuan, Michael Castaldo, Erik Skarsgard, Joseph Y. TingUniversity of British Columbia. University of Alberta.Canada Pediatrics and NeonatologyPediatr Neonatol 2026; DOI: 10.1016/j.pedneo.2025.11.011 AbstractBackground: Severe and persistent pulmonary hypertension (PH) predicts mortality and short-term pulmonary morbidity in infants with congenital diaphragmatic hernia (CDH). Intrathoracic liver herniation (liver-up) is a predictor of survival and increased

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Pre-discharge car seat tolerance screening in infants with CHD: a single-centre review

Nicholas V. Barresi, Mary D. Schiff, Frederick Roberts, Sierra Brooks, Olivia Frosch, Evonne MorellChildren’s Hospital of Pittsburgh and University of Pittsburgh.United States Cardiology in the YoungCardiol Young 2026; DOI: 10.1017/S1047951125110731 AbstractObjective: To evaluate car seat tolerance screening failure rate in infants with CHD, clinical factors associated with test failure, and the impact of a failed test.Methods: Single-centre retrospective

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Navigating the Unique Challenge of Pulmonary Hypertension From Left-to-Right PDA Shunts in Two Cases of Congenital Diaphragmatic Hernia

John T. Wren, Jr., Rhucha Joshi, Patrick J. McNamaraUniversity of Iowa Healthcare. Children’s Hospital of Orange County. United States EchocardiographyEchocardiography 2026; 43: DOI: 10.1111/echo.70396 AbstractPulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH) is nearly universal yet incredibly complex. A patent ductus arteriosus (PDA) is increasingly utilized to both monitor echocardiographically and manage CDH-PH. However, as pulmonary

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Neonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature

Anna Chiara Titolo, Mandy Ferrocino, Eleonora Biagi, Luisa Rizzo, Hajrie Seferi, Valentina Dell’Orto, Serafina Perrone, Susanna EspositoParma University Hospital and University of Parma.Italy DiagnosticsDiagnostics 2025; 15: DOI: 10.3390/diagnostics15243154 AbstractNeonatal pulmonary hypertension (PH) is a major cause of illness and death in newborns. Neonatologist-performed echocardiography (NPE) is increasingly used as a bedside tool to assess heart function,

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Investigation of vasoactive intestinal peptide expression and significance in a congenital diaphragmatic hernia animal model

Jiajun Chen, Huijiao Xu, Li Yang, Feifan Chen, Kunpeng Li, Bing Xu, Wenying Liu, Fang HouSichuan Provincial People’s Hospital and University of Electronic Science and Technology of China School of Medicine. China Pediatric Surgery InternationalPediatr Surg Int 2025; 42: DOI: 10.1007/s00383-025-06257-7 AbstractPurpose: To investigate vasoactive intestinal peptide (VIP) expression and distribution in fetal Sprague-Dawley (SD) rat lung

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Incidence and risk factors of pulmonary hypertension in neonates with congenital diaphragmatic hernia: a systematic review and meta-analysis

Rebeca Lopes Figueira, Fabian Doktor, Nazgol Moheimani, Giuseppe Lauriti, Jessie Lu, Giuseppe Speziale, Augusto ZaniHospital for Sick Children. Washington University School of Medicine. University of Leipzig Medical Center. “G. d’Annunzio” University of Chieti-Pescara, “Spirito Santo” Hospital of Pescara. Canada, United States, Germany and Italy Pediatric Surgery InternationalPediatr Surg Int 2025; 42: DOI: 10.1007/s00383-025-06247-9 AbstractPurpose: Pulmonary hypertension secondary

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