Class 3. Pulmonary Hypertension Associated with Airway Disease, Apnea or Hypoventilation

Images: Atypical resolution of sleep-related hypoventilation in congenital central hypoventilation syndrome

Michelle Yoo, Amit Shah, Haitham Shahrour, Hong Li, Ajay S. KasiEmory University and Children’s Healthcare of Atlanta.United States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2025;DOI: 10.5664/jcsm.11644 AbstractPaired-like homeobox 2B (PHOX2B) gene variants cause congenital central hypoventilation syndrome (CCHS) characterized by abnormal ventilatory control necessitating lifelong assisted ventilation (AV). We report a 3-year-old girl who […]

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A Comprehensive Review of Pediatric Obstructive Sleep Apnea: From Assessment to Intervention

Ulhas Jadhav, Jay Bhanushali, Arman Sindhu, Bingu Shiv Kiran Reddy, Amit Toshniwal, Mummaneni RashmikaJawaharlal Nehru Medical College and Datta Meghe Institute of Higher Education and Research.India CureusCureus 2025; 17: DOI: 10.7759/cureus.78051 AbstractPediatric obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by upper airway obstruction during sleep, leading to oxygen desaturation and sleep disruptions. This

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Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association

Jennifer K. Peterson, Shanelle Clarke, Bruce D. Gelb, Nadine A. Kasparian, Vanna Kazazian, Karyn Pieciak, Nancy A. Pike, Shaun P. Setty, Melissa K. Uveges, Nancy A. Rudd, the American Heart Association Pediatric Cardiovascular Nursing Committee of the Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; and Council on Cardiovascular Radiology and InterventionJohns Hopkins University School of Nursing. Children’s Hospital of Wisconsin. Children’s Healthcare Atlanta and Emory University.

Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association Read More »

NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea

Xiaoting Yangzhong, Shu Hua, Yiqiong Wen, Xiaoqing Bi, Min Li, Yuanyuan Zheng, Shibo SunFirst Affiliated Hospital, Kunming Medical University.China Current Molecular MedicineCurr Mol Med 2024; DOI: 10.2174/0115665240294605240426123650 AbstractObstructive sleep apnea [OSA] is widespread in the population and affects as many as one billion people worldwide. OSA is associated with dysfunction of the brain system that controls

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The First Korean Case with Cardiac, Facial, and Digital Anomalies with Developmental Delay Caused by De Novo TRAF7 p.Arg655Gln Variant

Kyung Hee Kim, Ji Yoon Han, Joonhong Park, Jung Sun ChoThe Catholic University of Korea. Jeonbuk National University Medical School and Hospital. Republic of Korea International Journal of Molecular SciencesInt J Mol Sci 2024; 25:DOI: 10.3390/ijms25073701 AbstractTRAF7-related disorders represent some of the rarest inherited disorders, exhibiting clinical features that overlap with cardiac, facial, and digital anomalies

The First Korean Case with Cardiac, Facial, and Digital Anomalies with Developmental Delay Caused by De Novo TRAF7 p.Arg655Gln Variant Read More »

Evaluation of Pre and Post-operative Pulmonary Artery Pressures in Children with Adenotonsillar Hypertrophy and Correlation with Chronicity: A Prospective Study on 50 Children

Khushboo Goel, Sanjeev Bhagat, Dinesh Kumar Sharma, Vishav Yadav, Peeyush Verma, Saivi RajdevGovernment Medical College. Employees State Insurance Model Hospital. India Indian Journal of Otolaryngology and Head and Neck SurgeryIndian J Otolaryngol Head Neck Surg 2024; 76: 639-644DOI: 10.1007/s12070-023-04235-w AbstractChildren with grade III or IV of adenotonsillar hypertrophy especially of a longer duration, may show cardiovascular

Evaluation of Pre and Post-operative Pulmonary Artery Pressures in Children with Adenotonsillar Hypertrophy and Correlation with Chronicity: A Prospective Study on 50 Children Read More »

Cardiac Implications of Adenotonsillar Hypertrophy and Obstructive Sleep Apnea in Pediatric Patients: A Comprehensive Systematic Review

Marco Zaffanello, Refika Hamutcu Ersu, Luana Nosetti, Giulio Beretta, Massimo Agosti, Giorgio PiacentiniUniversity of Verona. Children’s Hospital of Eastern Ontario and University of Ottawa. F. Del Ponte” Hospital and University of Insubria.Italy and Canada ChildrenChildren 2024; DOI: 10.3390/children11020208 AbstractThis review investigates the relationship between pediatric obstructive sleep apnea, often associated with adenotonsillar hypertrophy, and cardiovascular health,

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Elevated transaminases in congenital central hypoventilation syndrome

Rachel Y. Wang, Victoria S. Wang, Thomas G. Keens, Yan Chai, Nisreen Soufi, Iris A. PerezChildren’s Hospital Los Angeles.United States European Respiratory Journal Open ResearchERJ Open Res 2024; 10:DOI: 10.1183/23120541.00658-2023 AbstractPatients with CCHS who also have Hirschsprung disease, elevated or low BMI, or pulmonary hypertension may be predisposed to elevated transaminases and may need periodic follow-up

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Effect of face mask on pulmonary artery pressure during echocardiography in children and adolescents

Alireza Ahmadi, Mohammad Reza Sabri, Zohreh Sadat NavabiIsfahan University of Medical Sciences.Iran Clinical and Experimental PediatricsClin Exp Pediatr 2024;DOI: 10.3345/cep.2023.01172 AbstractBackground: Face masks have become an important tool for preventing the spread of respiratory diseases. However, we hypothesized that face masks with reduced nasal airflow may alter pulmonary artery systolic pressure (PASP).Purpose: This study aimed to evaluate the

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Prevalence of pulmonary hypertension in obstructive sleep apnea and relation to disease severity

Ian Milligan, Anna Kate Shaw, Roberta Leu, Usama Kanaan, Erik MichelfelderChildren’s Healthcare of Atlanta and Emory UniversityUnited States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2023;DOI: 10.5664/jcsm.10952 AbstractStudy objectives: The purpose of this study is to examine the prevalence of pulmonary hypertension (PHTN) in children with obstructive sleep apnea (OSA) using echocardiographic (ECHO) parameters and to

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