Class 3. Pulmonary Hypertension Associated with Developmental Diseases of the Lung

Rare Coding Variants in FOXF1 are Associated with Pulmonary Arterial Hypertension

Jose Gomez-Arroyo, Arjan C. Houweling, Alex V. Postma, Tushar Ganjawala, Dennis Dooijes, Harm Jan Bogaard, Jurjan Aman, Rob Zwart, Joseph A. Kizmiller, Gabriëla G. Edel, Aleksey Porollo, Lilian J. Meijboom, Nidhy P. Varghese, Philip Hale, Jason Hong, Na Zhu, Carrie L. Welch, Yufeng Shen, Francis X. McCormack, Micheala A. Aldred, Matthew T. Weirauch, Robbert J.

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Neonatal extracorporeal membrane oxygenation in congenital urinary tract obstruction with pulmonary hypoplasia: a case complicated by alveolar capillary dysplasia emphasizing importance of early rapid genetic testing

Ahreen Allana, Syed Talha Ahmed, Tavleen Sandhu, Sadori Khawaja, Keri Drake, Laura Mackay, Abhishek MakkarChildren’s Hospital of Dallas, University of Texas Southwestern.United States Pediatric NephrologyPediatr Nephrol 2026; DOI: 10.1007/s00467-026-07550-w AbstractA late preterm male infant born at 36 weeks and 2 days of gestation with birth weight of 2.5 kg and prenatally diagnosed bilateral hydronephrosis, megaureter,

Neonatal extracorporeal membrane oxygenation in congenital urinary tract obstruction with pulmonary hypoplasia: a case complicated by alveolar capillary dysplasia emphasizing importance of early rapid genetic testing Read More »

Congenital Pulmonary Lymphangiectasia With Alveolar Capillary Dysplasia in a Neonate With Obstructed Supracardiac Total Anomalous Pulmonary Venous Drainage: A Case Report

Deepan Raj, V. V. Vishnampettai, Lian Dwp, H. L. Chin, Aye Wmm, Goh Dyt. R. T. Grignani, Lim MtcKhoo Teck Puat-National University Children’s Medical Institute, National University Hospital and National University Health System. Kanchi Kamakoti CHILDS Trust Hospital. Yong Loo Lin School of Medicine and National University of Singapore. National University Heart Centre.Singapore and India

Congenital Pulmonary Lymphangiectasia With Alveolar Capillary Dysplasia in a Neonate With Obstructed Supracardiac Total Anomalous Pulmonary Venous Drainage: A Case Report Read More »

Survival Into Adulthood With FOXF1-Associated Pulmonary Vascular Disease After Neonatal Onset

Khalifah A. Aldawsari, Steven H. Abman, David Badesch, David Dunbar IvyUniversity of Colorado Anschutz Medical School and Children’s Hospital Colorado. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70378 AbstractNeonates and infants with FOXF1 mutation develop alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV), which is typically considered a uniformly fatal neonatal lung disorder due

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Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy

Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed AlfadhelAbdullah Specialized Children Hospital and King Abdulaziz Medical City. King Saud Bin Abdulaziz University for Health Sciences. King Abdullah International Medical Research Center. Saudi Arabia Respiratory Medicine Case ReportsRespir Med Case Rep 2026; 62: DOI: 10.1016/j.rmcr.2026.102456 AbstractBackground: Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD-MPV) is a rare

Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy Read More »

Alveolar capillary dysplasia with misalignment of pulmonary veins in neonates: a multicenter cohort study

Prithvi Sendi, Paul Martinez, Kaitlin Kobaitri, Balagangadhar R. TotapallyNicklaus Children’s Hospital. Herbert Wertheim College of Medicine and Florida International University.United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05265-0 AbstractBackground: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare developmental lung disorder associated with high neonatal mortality. We aimed to describe the epidemiology, resource utilization, and

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Alveolar Capillary Dysplasia With Misaligned Pulmonary Veins (ACDMPV): Description of Two Cases and Literature Review

Eleanora Guasti, Giacomo Tardini, Silvia Buratti, Chiara Campone, Erika Alboreto, Martino Cheli, Francesca Faravelli, Daniela Pirlo, Andrea MoscatelliUniversity of Genoa. IRCCS Istituto Giannina Gaslini. Italy Pediatric PulmonologyPediatr Pulmonol 2026; 61: DOI: 10.1002/ppul.71704 AbstractIntroduction: Alveolar capillary dysplasia with misaligned pulmonary veins (ACDMPV) is one of the major causes of neonatal interstitial lung disease, causing persistent pulmonary hypertension (PH)

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Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant

Jennifer A. Wambach, F. Sessions Cole, Lawrence M. NogeeWashington University School of Medicine and St. Louis Children’s Hospital. Johns Hopkins University. United States Clinics in PerinatologyClin Perinatol 2026; 53: 381-401DOI: 10.1016/j.clp.2026.03.003 AbstractHypoxemic respiratory failure is a common reason for admission to the neonatal intensive care unit for term and late preterm infants. Some infants have rare

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Phenotyping persistent pulmonary hypertension of the newborn: recognition of its persistence across world symposium on pulmonary hypertension classifications

Stephanie M. Tsoi, Philip T. Levy, Steven H. Abman, Nidhy P. VargheseBenioff Children’s Hospital and University of California, San Francisco. Harvard Medical School and Boston Children’s Hospital. University of Colorado Anschutz Medical School and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02704-y AbstractThe earliest clinical

Phenotyping persistent pulmonary hypertension of the newborn: recognition of its persistence across world symposium on pulmonary hypertension classifications Read More »

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension

Lea C. Steffes, Kaylie A. Chiles, Sehar R. Masud, Aleen Rahman, Madeline Dawson, Csaba Galambos, Maya E. Kumar, Ripla AroraStanford University School of Medicine. Michigan State University. University of Colorado School of Medicine and Children’s Hospital Colorado.United States Journal of Clinical Investigation InsightsJCI Insights 2026; DOI: 10.1172/jci.insight.194251 AbstractHeterozygous TBX4 variants are the second most common genetic

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