Class 1. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease

Phenoxybenzamine: Old Wine in a Bright New Bottle-Taming the wild side of Phenoxybenzamine

R. Benedict Raj, Srinath Reddy Narahari, Vasudev Vemala, Jyotiprakash ReddyAster Ramesh Hospitals.India Journal of Pharmacy and BioAllied SciencesJ Pharm Bioall Sci 2025; 17 (Suppl 3): S2135-S2137DOI: 10.4103/jpbs.jpbs_868_25 AbstractBackground: Phenoxybenzamine (PBZ), a long-acting α-blocker, was once widely used in pediatric cardiac surgeries but fell out of favor due to concerns about systemic hypotension. In the context of developing […]

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Treatment options for children with pulmonary arterial hypertension associated with congenital heart disease

Julie Wacker, Raphael Joye, Maurice BeghettiGeneva University Hospitals.Switzerland Expert Review of Respiratory MedicineExpert Rev Respir Med 2025; DOI: 10.1080/17476348.2025.2581340 AbstractIntroduction: Pulmonary hypertension associated with congenital heart disease (PAH-CHD) represents one of the leading causes of pediatric pulmonary hypertension. Within this entity, patients can be classified into distinct subgroups, each characterized by specific clinical features, pathophysiological mechanisms, and

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Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study

Yuko Walisaka, Kei Inai, Gen Harada, Seiji Asagai, Eriko ShimadaTokyo Women’s Medical University.Japan Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125110159 AbstractBackground: Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been reported, especially before

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study Read More »

Successful percutaneous closure of ventricular septal defects associated with pulmonary hypertension using different atrial septal defect Occluders: A report of two cases

José Luis Colín-Ortiz, Rogelio Zúñiga-Gordillo, Linda Fabiola Pérez-Pérez, Carlos Balcázar-Ochoa, Roberto Tepatzi-Carranco, Rosa María García-MejíaHospital of Poblano Child. Southern General Hospital of Puebla. Tlaxcala’s Children Hospital.Mexico Journal of Cardiology CasesJ Cardiol Cases 2025; 32: 171-174DOI: 10.1016/j.jccase.2025.06.010 AbstractWe present two cases of children with muscular ventricular septal defects (mVSD) and severe pulmonary hypertension. Both children successfully underwent

Successful percutaneous closure of ventricular septal defects associated with pulmonary hypertension using different atrial septal defect Occluders: A report of two cases Read More »

A multimodal multipath AI system for assessing PAH after VSD correction on echocardiography and chest radiography images

Gang Luo, Huashu Liu, Zhixin Li, Zhixian Ji, Silin PanWomen and Children’s Hospital, Qingdao Central Hospital and Qindao Medical College of Qingdao University. China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-19584-5 AbstractDeveloping a novel artificial intelligence (AI) system that can automatically detect pulmonary arterial hypertension (PAH) after correcting the ventricular septal defect (VSD) and to help

A multimodal multipath AI system for assessing PAH after VSD correction on echocardiography and chest radiography images Read More »

Comparative assessment of nutritional status in unoperated children with Congenital Heart Defects: Insights from a tertiary pediatric cardiac center in India

Radha Joshi, Manasi Bhoite, Poonam Mandhare, Shaoni Nath, Sudhir Kapoor1, Rishikesh Wadke, Ragini PandeySri Sathya Sai Sanjeevani Research Foundation and Centre for Child Heart Care and Training in Paediatric Cardiac Skills. India Public Library of Science Global Public HealthPLOS Glob Publi Health 2025; 5: DOI: 10.1371/journal.pgph.0005260 AbstractCongenital Heart Defects (CHD) are structural cardiac malformations ranging from

Comparative assessment of nutritional status in unoperated children with Congenital Heart Defects: Insights from a tertiary pediatric cardiac center in India Read More »

Congenital extrahepatic portosystemic shunt with partial anomalous pulmonary venous return and aneurysmal dilation of the pulmonary artery: successful management of a complex multisystem congenital anomaly

Sweta Mohanty, Shreesha Maiya, Dheeraj Kumar TiwariNarayana Health.India Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125109220 AbstractCongenital extrahepatic portosystemic shunt (CEPS) is an uncommon condition in which the portal vascular system drains into the systemic veins. We describe an unusual case of CEPS with congenital heart disease, presenting with aneurysmal enlargement of the pulmonary artery and

Congenital extrahepatic portosystemic shunt with partial anomalous pulmonary venous return and aneurysmal dilation of the pulmonary artery: successful management of a complex multisystem congenital anomaly Read More »

Efficacy and safety of treprostinil in pediatric pulmonary hypertension following fontan surgery: a real-world analysis

Mingjie Zhang, Xi Chen, Yahe Xu, Yijun Chen, Zhiyue Zhang, Jingru Zhou, Zhuoming XuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06097-3 AbstractIntroduction: This study aimed to evaluate the efficacy and safety of treprostinil in managing pulmonary hypertension (PH) following Fontan surgery in children. The

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Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension

Akari Sato, Mai Sekine, Hidenori Kawasaki, Masayo Kanai, Hirotaka Ishido, Yoichi Iwamoto, Hideaki Senzaki, Ayumu Masuoka, Fujito Numano, Jun Muneuchi, Norie Mitsushita, Satoshi MasutaniSaitama Medical Center and Saitama Medical University. Nihon Institute of Medical Science. International Medical Center. Niigata University Graduate School of Medical and Dental Sciences. Kyushu Hospital and Japan Community Healthcare Organization. Shizuoka

Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension Read More »

Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study

Takumi Yamaguchi, Yumi Tomonari, Shiori Utsunomiya, Nakako Fujioka, Takahiro AsanoJapan Community Health Care Organization Chukyo Hospital. Japan Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04041-x AbstractLow cardiac output syndrome (LCOS) is a critical complication following ventricular septal defect (VSD) closure in children. Despite its clinical importance, the risk factors specific to LCOS in VSD cases are underexplored. This

Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study Read More »

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