Class 1. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease

The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications

Sixie Zheng, Zheng Wang, Yiting Xue, He Zhang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Jing Wang, Lincai Ye, Lisheng QiuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Women and Children’s Hospital of Ningbo University. Children’s Hospital of Fudan University and National Children’s Medical Center. China Journal of […]

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Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature

Sixie Zheng, Hao Li, Siqi She, Yiting Xue, Debao Li, Jiapei Wang, Jing Wang, Yuqing Hu, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. Affiliated Women and Children’s Hospital of Ningbo University. China Frontiers in ImmunologyFront Immunol 2026; 17: DOI: 10.3389/fimmu.2026.1780303

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The Impact of Acute COVID-19 Infection and Long COVID in Patients with Congenital Heart Disease: A Longitudinal Study by the German National Register for Congenital Heart Disease

Cornelia Tremblay, Ulrike M. M. Bauer, Jens Beudt, Stefan Orwat, Gerhard-Paul Diller, Constanze Pfitzer, Paul C. HelmNational Register for Congenital Heart Defects. Competence Network for Congenital Heart Defects. University Hospital Muenster. Deutsches Herzzentrum der Charité. Freie Universität Berlin and Humboldt-Universität zu Berlin. Germany Journal of Clinical MedicineJ Clin Med 2026; 15: DOI: 10.3390/jcm15051986 AbstractBackground: Patients with congenital

The Impact of Acute COVID-19 Infection and Long COVID in Patients with Congenital Heart Disease: A Longitudinal Study by the German National Register for Congenital Heart Disease Read More »

Protocol for an open-label, randomised, controlled trial to evaluate the efficacy and safety of sotatercept add-on therapy compared with pulmonary vasodilator-based standard of care for pulmonary vasodilator-resistant pulmonary arterial hypertension associated with unrepaired congenital shunts (atrial septal defect, ventricular septal defect or patent ductus arteriosus), including Eisenmenger syndrome: the SuMILE trial

Keimei Yoshida, Kazuya Hosokawa, Takahiro Hiraide, Satoshi Akagi, Kentaro Ejiri, Yu Taniguchi, Shiro Adachi, Takumi Inami, Naohiko Nakanishi, Masaharu Kataoka, Taijyu Satoh, Shunsuke Tatebe, Toshiro Shinke, Hideshi Tomita, Yusuke Akazawa, Takashi Higaki, Koshiro Tagawa, Ayako Ishikita, Soshun Asakawa, Kohtaro AbeKyushu University and Kyushu University Hospital. Keio University School of Medicine. Okayama University. Kobe University Hospital.

Protocol for an open-label, randomised, controlled trial to evaluate the efficacy and safety of sotatercept add-on therapy compared with pulmonary vasodilator-based standard of care for pulmonary vasodilator-resistant pulmonary arterial hypertension associated with unrepaired congenital shunts (atrial septal defect, ventricular septal defect or patent ductus arteriosus), including Eisenmenger syndrome: the SuMILE trial Read More »

Sotatercept in Patients With Eisenmenger Syndrome

Oktay Tutarel, Oliver Miera, Felix BergerDeutsches Herzzentrum der Charité, Freie Universität Berlin and Humboldt-Universität zu Berlin.Germany Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70283 AbstractEisenmenger syndrome represents a complex and severe form of pulmonary arterial hypertension (PAH) associated with congenital heart disease. Sotatercept, a first-in-class activin-signaling inhibitor, offers a novel therapeutic approach in the treatment of PAH,

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Reversing the irreversible? A case of successful surgical repair in a late-presenting aortopulmonary window with severe pulmonary hypertension

Rido Mulawarman, Ericko Ongko Joyo, Muhamad Adrin Aefiansyah Putra, Aditya Agita Sembiring, Sisca Natalia Siagian, Oktavia LilyasarUniversitas Indonesia. Indonesia Egyptian Heart JournalEgypt Heart J 2026; 78: DOI: 10.1186/s43044-026-00726-7 AbstractBackground: Aortopulmonary window (APW) is a rare congenital heart defect, accounting for only 0.2-0.6% of all congenital cardiac anomalies, and is usually identified and surgically corrected within the first

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A Combination Of Vein Of Galen Aneurysmal Malformation And Bovine Aortic Arch In Newborn: A Case Report

Krishna Deo Mandal, Kalpana Subedi, Unnati Amatya, Janak PathakParopakar Maternity and Women’s Hospital. Embassy of India.Nepal Journal of the Nepal Medical AssociationJ Nepal Med Assoc 2025; 63: 347-349DOI: 10.31729/jnma.8987 AbstractVein of Galen aneurysmal malformation is a rare intracranial arteriovenous malformation, coexistence with aortic arch anomalies is even more uncommon, carry high risk of morbidity and mortality

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Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries

Keiichi Hirono, Keiko Uchida, Taku Ishii, Hidekazu Ishida, Shinichi Takatsuki, Hiroyuki Fukushima, Kei Inai, Susumu Hosokawa, Reina Ishizaki, Hirofumi Sawada, Naofumi F. Sumitomo, Ayako Chida-Nagai, Yuichi Ishikawa, Hirohiko Motoki, Atsushi Yao, Shigetoyo Kogaki, Hiroyuki Yamagishi, Shozaburo DoiToyama University Hospital. Tokyo Medical University. Institute of Science Tokyo. Osaka University Graduate School of Medicine. Toho University, Omori

Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries Read More »

Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross-Sectional Study

Saviga Sethasathien, Chanon Kunasol, Suchaya Silvilairat, Rekwan Sittiwangkul, Pannipa Suwannasom, Nipon Chattipakorn, Krit Leemasawat, Siriporn C. ChattipakornChiang Mai University. Thailand Journal of the American Heart AssociationJ Am Heart Assoc 2026; DOI: 10.1161/JAHA.125.045962 AbstractBackground: The Fontan operation results in chronic hemodynamic alterations, including central venous hypertension, which may contribute to gut dysbiosis. This study aimed to compare gut

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Microbiome-Metabolome Axis in BALF Reveals Novel Diagnostic Biomarkers for Congenital Heart Disease-Associated Pulmonary Arterial Hypertension

Xiaoyu Zhang, Liming Cheng, Yuan Zhou, Jiahui Xie, Wenting Gui, Jiaxiang Chen, Zidan Zhang, Kai Liu, Runwei MaFuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University. Kunming Children’s Hospital.China Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2026; 13: DOI: 10.3390/jcdd13010032 AbstractBackground: Early identification of irreversible pulmonary vascular remodeling in

Microbiome-Metabolome Axis in BALF Reveals Novel Diagnostic Biomarkers for Congenital Heart Disease-Associated Pulmonary Arterial Hypertension Read More »

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