Class 1. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease

Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children

Yanyun Huang, Yuting Chen, Danyan Su, Suyuan Qin, Cheng Chen, Dongli Liu, Bingbing Ye, Yuqin Huang, Piaoliu Yuan, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1562782 AbstractBackground: Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its long-term effects […]

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Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation

Benjamin S. Frank, Sierra Niemiec, Ludmila Khailova, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Carmen C. Sucharov, Jesse A. DavidsonUniversity of Colorado. University of Michigan.United States Journal of the American College of Cardiology AdvancesJACC Adv 2025; 4: DOI: 10.1016/j.jacadv.2025.101672 AbstractBackground: Endothelin-1 (ET1) is a potent vasoconstrictor and stimulator of pulmonary

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Airway Anomalies Predict Risk of Pediatric Pulmonary Hypertension

Elana R. Kriegel, Aditya Srinivasen, Luke Mammen, Harini Venkataganesh, Jess T. Randall, Lara ReichertAlbany Medical College and Albany Medical Center.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71028 AbstractIntroduction: Pediatric pulmonary hypertension (PH) significantly contributes to morbidity and mortality due to the progressive nature of the disease in some subtypes, which leads to severe right heart failure,

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Long-term survival of shunt closure in atrial septal defects with pulmonary arterial hypertension

Wenjie Chen, Jingyuan Chen, Min Peng, Jun Luo, Haihua Qiu, Yusi Chen, Jiang LiSecond Xiangya Hospital of Central South University. China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133094 AbstractObjective: This study aims to refine closure indications and assess long-term outcomes in pulmonary arterial hypertension associated with atrial septal defect (PAH-ASD).Methods: We enrolled 197 PAH-ASD patients classified

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Pulmonary artery systolic pressure associated with inflammatory factors among pediatric congenital heart disease with pulmonary arterial hypertension after cardiopulmonary bypass

WenJuan Li, Wenyuan Shang, Jihong HuangXinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine.China Jornal de PediatriaJ Pediatr 2025; DOI: 10.1016/j.jped.2025.01.006 AbstractObjective: This study aimed to evaluate the perioperative inflammatory cytokines in pediatric patients with pulmonary arterial hypertension secondary to congenital heart disease and also sought to investigate the correlation between preoperative echocardiographic pulmonary artery

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Ultrasonographic diagnosis and follow-up of a special type of giant fetal hepatic hemangioma

Xiaoyan Weng, Juan Jiang, Gang WenWomen and Children’s Hospital Affiliated to Ningbo University. China Pediatric RadiologyPediatr Radiol 2025; DOI: 10.1007/s00247-025-06196-4 AbstractWe present a case of giant fetal hepatic hemangioma to illustrate the impact of ultrasound monitoring on treatment outcomes. Prenatal ultrasound revealed cardiac enlargement, leading to a cesarean section. The neonate had multiple vascular anomalies, including

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Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta

Ahmed Younis, Yogesh N. V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. EgbeMayo Clinic.United States International Journal of Cardiology Heart and VasculatureInt J Cardiol Heart Vasc 2025; 57: DOI: 10.1016/j.ijcha.2025.101626 AbstractBackground: Pulmonary hypertension (PH) affects 20% of adults with coarctation of aorta (COA). What is not known is whether

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Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

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Unusual presentation of anomalous origin of the right pulmonary artery from the ascending aorta: case report

Mohamed Elhudairy, Naif Alkhushi, Osman Al‑Radi, Khadijah Maghrabi, Gaser AbdelmohsenKing Abdul-Aziz University. Kasr Al Ainy School of Medicine and Cairo University.Saudi Arabia and Egypt Egypt Heart JournalEgypt Heart J 2025; 77: DOI: 10.1186/s43044-025-00614-6 AbstractBackground: Anomalous origin of the right pulmonary artery (AORPA) from the ascending aorta is a rare congenital anomaly, representing approximately 0.12% of all congenital

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Beating the odds: Rare prolonged survival of truncus arteriosus: A case report with literature review

Obuoma Umejuru Amaewhule, Barbara Edewele Otaigbe, Petronila Nnenna Tabansi, Rosemary Atsosime Uwadiale, Victoria Ezinne Emeruwa, Faithful Miebaka DanielRivers State University Teaching Hospital. University of Port Harcourt Teaching Hospital. First On-Call Initiative. London School of Hygiene and Tropical Medicine.Nigeria, Ukraine and United Kingdom MedicineMedicine 2025; 104: DOI: 10.1097/MD.0000000000041324 AbstractRationale: Truncus arteriosus is a cyanotic congenital heart disease in which

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