Class 1. Persistent Pulmonary Hypertension of the Newborn

Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. RottkampUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2024; 51: 271-289DOI: 10.1016/j.clp.2023.10.002 AbstractLong-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN […]

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Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review

Kristen Coletti, K. Taylor Wild, Elizabeth E. Foglia, Suzan Cochius-den Otter, Haresh KirpalaniChildren’s Hospital of Philadelphia and University of Pennsylvania. Erasmus MC University Medical Center.United States and Netherlands Clinics in PerinatologyClin Perinatol 2024; 51: 253-269DOI: 10.1016/j.clp.2023.11.009 AbstractInhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn.

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Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings

Prathik Bandiya, Rajeshwari Madappa, Ajay Raghav JoshiSouth Hospital Complex and Dharmaram College Post. SIGMA Hospital. India Clinics in PerinatologyClin Perinatol 2024; 51: 237-252DOI: 10.1016/j.clp.2023.11.002 AbstractPersistent Pulmonary Hypertension of the Newborn (PPHN) is more common in low and middle income countries (LMICs) due to high incidence of sepsis, perinatal asphyxia and meconium aspiration syndrome. Presence of hypoxic

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Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension

Regan Geisinger, Danielle R. Rios, Patrick J. McNamara, Philip T. LevyUniversity of Iowa. Boston Children’s Hospital and Harvard Medical School.United States Clinics in PerinatologyClin Perinatol 2024; 51: 127-149DOI: 10.1016/j.clp.2023.11.007 AbstractNeonates with a perinatal hypoxic insult and subsequent neonatal encephalopathy are at risk of acute pulmonary hypertension (aPH) in the transitional period. The phenotypic contributors to aPH

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Targeted Therapies for Neonatal Pulmonary Hypertension: Beyond Nitric Oxide

Jeanne Carroll, Rohit Rao, Robin H. SteinhornUniversity of California, San Diego and Rady Children’s Hospital. United States Clinics in PerinatologyClin Perinatol 2024; 51: 113-126DOI: 10.1016/j.clp.2023.11.008 AbstractPulmonary hypertension in the neonatal population can be acute or chronic and carries significant risk for morbidity and mortality. It can be idiopathic but more often is associated with comorbid pulmonary

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Pulmonary Vascular Regulation in the Fetal and Transitional Lung

Hannah Holmes, Brahmdeep S. Saini, Olivia J. Moir, Jack R. T. Darby, Janna L. Morrison, Liqun Sun, Mike SeedHospital for Sick Children and University of Toronto. University of South Australia. Canada and Australia Clinics in PerinatologyClin Perinatol 2024; 51: 1-19DOI: 10.1016/j.clp.2023.11.003 AbstractFetal lungs have fewer and smaller arteries with higher pulmonary vascular resistance (PVR) than a

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Guidelines and Recommendations for Targeted Neonatal Echocardiography and Cardiac Point-of-Care Ultrasound in the Neonatal Intensive Care Unit: An Update from the American Society of Echocardiography

Patrick J. McNamara, Amish Jain, Afif El-Khuffash, Regan Giesinger, Dany Weisz, Lindsey Freud, Philip T. Levy, Shazia Bhombal, Willemde Boode, Tina Leone, Bernadette Richards, Yogen Singh, Jennifer M. Acevedo, John Simpson, Shahab Noori, Wyman W. LaiUniversity of Iowa. University of Toronto. Royal College of Surgeons in Ireland. Boston Children’s Hospital and Harvard Medical School. Emory

Guidelines and Recommendations for Targeted Neonatal Echocardiography and Cardiac Point-of-Care Ultrasound in the Neonatal Intensive Care Unit: An Update from the American Society of Echocardiography Read More »

Challenges in clinical identification of right ventricular dysfunction in preterm infants with persistent pulmonary hypertension of the newborn

Faith Zhua, Caio Barbosa de Oliveira, Nada Mohsen, Ashraf Kharrat, Poorva Deshpande, Luc Mertens, Amish JainMount Sinai Hospital, Hospital for Sick Children and University of Toronto.Canada Early Human DevelopmentEarly Hum Dev 2024; 190DOI: 10.1016/j.earlhumdev.2024.105942 AbstractBackground: Right ventricular dysfunction, typically qualitatively diagnosed (Q-RVd) in preterm infants, requires echocardiography which is not always acutely available. We aimed to identify

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Short term effect of intravenous treprostinil in term and preterm infants with pulmonary hypertension

Yoo-Jin Kim, Seung Han Shin, Ee-Kyung Kim, Han-Suk KimChung-buk National University Hospital. Seoul National University College of Medicine. Seoul National University Children’s Hospital. Republic of Korea BioMed Central PediatricsBMC Pediatr 2024; 23:DOI: 10.1186/s12887-023-04501-4 AbstractBackground: Pulmonary hypertension (PH) is a life-threatening condition in newborns. We aimed to assess the clinical and echocardiographic responses of term and preterm infants

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Case Report: Stüve-Wiedemann syndrome-a rare cause of persistent pulmonary hypertension of the newborn

Jessica Jin, Paula Rothämel, Johanna Büchel, Birgit Kammer, Theresa Brunet, Joseph Pattathu, Andreas W. Flemmer, Claudia Nussbaum, Sebastian SchroepfDr. von Hauner Children’s Hospital, University Hospital and Ludwig-Maximilians-Universität. University Hospital and Technical University of Munich. Germany Frontiers in PediatricsFront Pediatr 2024;DOI: 10.3389/fped.2023.1329404 AbstractIntroduction: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition characterized by hypoxemia due

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