Class 1. Persistent Pulmonary Hypertension of the Newborn

Shape of Pulmonary Artery Doppler Flow Profile and Right Ventricular Hemodynamics in Neonates

Sébastien Joye, Soume Bhattacharya, Ashraf Kharrat, Bonny Jasani, Regan E. Giesinger, Patrick J. McNamara, Amish JainLausanne University Hospital. LHSC Children’s Hospital. Mount Sinai Hospital and University of Toronto. Hospital of Sick Children. University of Iowa. Switzerland, Canada and United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113864 AbstractObjectives: To characterize pulmonary artery Doppler flow profile (PAFP) patterns

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Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Willem P. de Boode, Afif El-Khuffash, Orla Franklin, Eleanor J. Molloy, Infection, Inflammation, Immunology and Immunisation Section of the European Society for Pediatric Research (ESPR)Children’s Health Ireland at Crumlin. University of California, Davis Children’s Hospital. British Columbia Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Royal

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Risk factors for death caused by early onset sepsis in neonates: a retrospective cohort study

Xinhong Chen, Huayun He, Hong Wei, Feng Chen, Ya HuChildren’s Hospital of Chongqing Medical University. National Clinical Research Center for Child Health and Disorders. Ministry of Education Key Laboratory of Child Development and Disorders.China BioMed Central Infectious DiseasesBMC Infect Dis 2023; DOI: 10.1186/s12879-023-08851-3 AbstractObjective: To evaluate the association between traditional laboratory findings and death, and to find

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Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study

Enhuan Wei, Xiu-hua Chen, Si-Jia ZhouAffiliated Sanming First Hospital and Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) of Fujian Medical University.China Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1270712 AbstractBackground: This study aims to evaluate the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN).Methods: We conducted a retrospective cohort

Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study Read More »

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

Jamie L. Archambault, Cassidy A. DelaneyUniversity of Colorado.United States BiomedicinesBiomedicines 2023; 11: DOI: 10.3390/biomedicines11113049 AbstractSerotonin (5-HT) is a bioamine that has been implicated in the pathogenesis of pulmonary hypertension (PH). The lung serves as an important site of 5-HT synthesis, uptake, and metabolism with signaling primarily regulated by tryptophan hydroxylase (TPH), the 5-HT transporter (SERT), and

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Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn

Stephanie M. Tsoi, Hythem Nawaytou, Hassan Almeneisi, Martina Steurer, Yili Zhao, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26759 AbstractBackground: Neonates with persistent pulmonary hypertension of the newborn (PPHN) can present with hypoxia and right ventricular dysfunction with resultant inadequate oxygen delivery and end-organ damage. This study describes

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Impact of persistent pulmonary hypertension and oxygenation on brain injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia

Keira C. Kilmartin, Asim Al Balushi, Gabriel Altit, Anie Lapointe, Emmanouil Rampakakis, Stephanie Barbosa Vargas, Julie Maluorni, Pia WintermarkMontreal Children’s Hospital and McGill University. National Heart Centre. University of Montreal. Canada and Oman Journal of PerinatologyJ Perinatol 2023; DOI: 10.1038/s41372-023-01805-2 AbstractObjective: To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with

Impact of persistent pulmonary hypertension and oxygenation on brain injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia Read More »

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN)

Irfan Shehzad, Ashish Banker, Bibhuti Das, Adil Humayun, Hale Wills, Muppala Raju, Niraj VoraBaylor Scott & White Health.United States CureusCureus 2023; DOI: 10.7759/cureus.45595 AbstractDespite improvements in the medical management of persistent pulmonary hypertension of the newborn (PPHN), a significant number of patients persist with inadequate gas exchange and are treated with extracorporeal membrane oxygenation (ECMO). Prolonged

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

A Neonate With Cytokine Storm Managed With Steroids, Therapeutic Plasma Exchange, and Tocilizumab

Amy LiKamWa, Kaitlin Kobaitri, Balagangadhar R. TotapallyHerbert Wertheim College of Medicine. Nicklaus Children’s Hospital.United States CureusCureus 2023; 15DOI: 10.7759/cureus.45138 AbstractNeonatal cytokine storms, though rare, can induce hyperinflammation due to elevated interleukin-6 (IL-6), triggering multiorgan failure. We present the case of a term male neonate necessitating extracorporeal membrane oxygenation (ECMO) post-birth for persistent pulmonary hypertension due to

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Incidence and types of congenital heart disease at a referral hospital in Jordan: retrospective study from a tertiary center

Abeer A. Hasan, Naser Aldain A. Abu Lehyah, Moath K. Al Tarawneh, Mahmoud Y. Abbad, Areen G. Fraijat, Razan A. Al-Jammal, Dania M. Moamar, Qasem A. Shersheer, Scott O. Guthrie, Joseph R. StarnesMaternity and Children’s Hospital at Al Bashir Hospital. Vanderbilt University Medical Center, Nashville.Jordan and United States Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1261130 AbstractBackground: Congenital

Incidence and types of congenital heart disease at a referral hospital in Jordan: retrospective study from a tertiary center Read More »

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