Class 1. Persistent Pulmonary Hypertension of the Newborn

Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure

Timothy J. Boly, John M. Dagle, Jonathan M. Klein, Danielle R. Rios, Patrick J. McNamara, Regan E. GiesingerUniversity of Iowa.United States Journal of PerinatologyJ Perinatol 2023; 43: 324-331DOI: 10.1038/s41372-022-01582-4 AbstractObjective: To evaluate the outcomes of extremely premature infants who received inhaled nitric oxide(iNO) for hypoxic respiratory failure(HRF).Study design: Retrospective analysis of 107 infants born 22-26 weeks gestation who […]

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Use of Vasopressin as Rescue Therapy in Refractory Hypoxia and Refractory Systemic Hypotension in Term Neonates with Severe Persistent Pulmonary Hypertension-A Prospective Observational Study

Sachin Shah, Saleha Dhalait, Anurag Fursule, Jayant Khandare, Amita KaulSurya Mother & Child Superspeciality Hospital.India America Journal of PerinatologyAm J Perinatol 2022; DOI: 10.1055/a-1969-1119 AbstractObjective: Persistent pulmonary hypertension of the newborn (PPHN) is a serious cardiorespiratory problem. PPHN is frequently associated with refractory hypoxia and hypotension, and optimal management has the potential to improve important clinical outcomes

Use of Vasopressin as Rescue Therapy in Refractory Hypoxia and Refractory Systemic Hypotension in Term Neonates with Severe Persistent Pulmonary Hypertension-A Prospective Observational Study Read More »

Predicting the Severity and Outcome of Persistent Pulmonary Hypertension of the Newborn Using New Echocardiography Parameters

Muhammad Umer Butt, Ahmad Jabri, Hani Hamade, Ahmad Al Abdouh, Mohammed Mhanna, Faris Haddadin, Farhan Nasser, Nour Hammad, Deaa Abu Jazar, Ahmad J. Toumar, Aisha Siraj, Kathir Balakumaran, Michel IlbawiMetrohealth Medical Center. St. Agnes Hospital. University of Toledo. Baylor College of Medicine. University Hospitals Cleveland Medical Centers. University of Texas Medical Branch. Kent Hospital. Advocate Children’s

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Neonatal mortality and morbidity in Down syndrome in the time of prenatal aneuploidy testing: a retrospective cohort study

Maurike Dorothea de Groot‑van der Mooren, Lukas Augustinus, Johannes Rammeloo. Roos van der Plas, Peter de Winter, Hester van Wieringen, Anne‑Marie van Wermeskerken, Michel Emile Weijerman, Anton Hubertus van KaamAmsterdam UMC Location and University of Amsterdam. Amsterdam Public Health Research Institute. Amsterdam Reproduction & Development Research Institute. St. Antonius Ziekenhuis. Flevoziekenhuis, Hospitaalweg. Spaarne Gasthuis. KU Leuven. Alrijne Hospital. Netherlands European Journal of PediatricsEur J Pediatr 2023; 182: 319-328DOI: 10.1007/s00431-022-04686-3 AbstractThe total uptake of prenatal aneuploidy screening for Down syndrome

Neonatal mortality and morbidity in Down syndrome in the time of prenatal aneuploidy testing: a retrospective cohort study Read More »

Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness

Julie Dillard, Leeann R. Pavlek, Saichidroopi Korada, Bernadette ChenSt. Louis University. Nationwide Children’s Hospital and Ohio State University.United States Journal of PerinatologyJ Perinatol 2022; 42: 37-44DOI: 10.1038/s41372-021-01228-x AbstractObjectives: To identify distinguishing characteristics of neonates with persistent pulmonary hypertension of the newborn (PPHN) unresponsive to inhaled nitric oxide (iNO) and evaluate the use of milrinone in this cohort.Study

Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness Read More »

Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy

Lucie Genet, Daniele De Luca“A.Béclère” Medical Center and Paris Saclay University Hospitals.France Cardiology in the YoungCardiol Young 2022; 32: 996-997DOI: 10.1017/S1047951121004157 AbstractPersistent pulmonary hypertension of the neonate can cause acute and life-threatening hypoxia, but preterm neonates are not suitable candidate to extra-corporeal life support. We report the unique case of an extremely preterm neonates with life-threatening

Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy Read More »

Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model

Devashis Mukherjee, Ujala Rana, Alison J. Kriegel, Pengyuan Liu, Teresa Michalkiewicz, Girija Ganesh KonduriRainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Medical College of Wisconsin and Children’s Wisconsin.United States Pediatric ResearchPediatr Res 2022; 93: 551-558DOI: 10.1038/s41390-022-02151-3 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to

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Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant

Stephanie M. Tsoi, Kirk Jones, Elizabeth Colglazier, Claire Parker, Hythem Nawaytou, David Teitel, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pulmonary CirculationPul Circ 2022; 12: DOI: 10.1002/pul2.12108 AbstractWe present a case of a late preterm infant placed on extracorporeal life support in the first day of life for persistent pulmonary hypertension of

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Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry

Aravanan Anbu Chakkarapani, Samir Gupta, Asma Jamil, Santosh Kumar Yadav, Nim Subhedar, Helmut D. HummlerSidra Medicine. Weill Cornell Medicine-Qatar. Durham University. Johns Hopkins University School of Medicine. Liverpool Women’s Hospital. University of Tuebingen.Qatar, United Kingdom, United States and Germany European Journal of PediatricsEur J Pediatr 2022; 181: 3915-3922DOI: 10.1007/s00431-022-04602-9 AbstractThis study aims to assess the effects of inhaled nitric oxide (iNO) on oxygenation in the

Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry Read More »

A nomogram prediction model for early death in patients with persistent pulmonary hypertension of the newborn

Chuyang Lin, Jiao Mi, Yinyue Zhang†, Sichen Duan, Jinlin Wu, Yifei LiWest China Second University Hospital and Sichuan University.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: DOI: 10.3389/fcvm.2022.1077339 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a major lethal disorder in neonates that leads to an extremely high mortality rate. Thus, the early identification of

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