Class 1. Persistent Pulmonary Hypertension of the Newborn

Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature

Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia, Andrea Dotta, Flaminia Calzolar“Bambino Gesù” Children’s Hospital IRCCS. Monaldi Hospital.Italy Italian Journal of PediatricsItal J Pediatr 2024; 50:DOI: 10.1186/s13052-024-01575-3 AbstractTBX4 gene, located on human […]

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Serum pentraxin 3 levels in term neonates with persistent pulmonary hypertension

A. E. A. Asal, Z. F. Oshaiba, E. N. A. Mansour, O. H. Abd Elazir, A. A. A. NasrAl-Azhar University (for girls).Egypt Journal of Neonatal and Perinatal MedicineJ Neonatal Perinatal Med 2024;DOI: 10.3233/NPM-230211 AbstractBackground: Persistent pulmonary hypertension of the neonate (PPHN) is a serious disorder. The long pentraxin 3 (PTX3) plays an important role in angiogenesis, cell

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Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension

Michael W. Cookson, John P. KinsellaUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado.United States Clinics in PerinatologyClin Perinatol 2024; 51: 95-111DOI: 10.1016/j.clp.2023.11.001 AbstractPivotal trials investigating the use of inhaled nitric oxide (iNO) in the 1990s led to approval by the Food and Drug Administration in 1999. Inhaled nitric oxide is the only approved

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Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, “Precision-Medicine” Approach

Satyan Lakshminrusimha, Steven H. AbmanUniversity of California, Davis Children’s Hospital. University of Colorado Anschutz Medical Campus.United States Clinics in PerinatologyClin Perinatol 2024; 51: 77-94DOI: 10.1016/j.clp.2023.12.003 AbstractOxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clinical

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Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. RottkampUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2024; 51: 271-289DOI: 10.1016/j.clp.2023.10.002 AbstractLong-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN

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Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review

Kristen Coletti, K. Taylor Wild, Elizabeth E. Foglia, Suzan Cochius-den Otter, Haresh KirpalaniChildren’s Hospital of Philadelphia and University of Pennsylvania. Erasmus MC University Medical Center.United States and Netherlands Clinics in PerinatologyClin Perinatol 2024; 51: 253-269DOI: 10.1016/j.clp.2023.11.009 AbstractInhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn.

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Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings

Prathik Bandiya, Rajeshwari Madappa, Ajay Raghav JoshiSouth Hospital Complex and Dharmaram College Post. SIGMA Hospital. India Clinics in PerinatologyClin Perinatol 2024; 51: 237-252DOI: 10.1016/j.clp.2023.11.002 AbstractPersistent Pulmonary Hypertension of the Newborn (PPHN) is more common in low and middle income countries (LMICs) due to high incidence of sepsis, perinatal asphyxia and meconium aspiration syndrome. Presence of hypoxic

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Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension

Regan Geisinger, Danielle R. Rios, Patrick J. McNamara, Philip T. LevyUniversity of Iowa. Boston Children’s Hospital and Harvard Medical School.United States Clinics in PerinatologyClin Perinatol 2024; 51: 127-149DOI: 10.1016/j.clp.2023.11.007 AbstractNeonates with a perinatal hypoxic insult and subsequent neonatal encephalopathy are at risk of acute pulmonary hypertension (aPH) in the transitional period. The phenotypic contributors to aPH

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Targeted Therapies for Neonatal Pulmonary Hypertension: Beyond Nitric Oxide

Jeanne Carroll, Rohit Rao, Robin H. SteinhornUniversity of California, San Diego and Rady Children’s Hospital. United States Clinics in PerinatologyClin Perinatol 2024; 51: 113-126DOI: 10.1016/j.clp.2023.11.008 AbstractPulmonary hypertension in the neonatal population can be acute or chronic and carries significant risk for morbidity and mortality. It can be idiopathic but more often is associated with comorbid pulmonary

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Pulmonary Vascular Regulation in the Fetal and Transitional Lung

Hannah Holmes, Brahmdeep S. Saini, Olivia J. Moir, Jack R. T. Darby, Janna L. Morrison, Liqun Sun, Mike SeedHospital for Sick Children and University of Toronto. University of South Australia. Canada and Australia Clinics in PerinatologyClin Perinatol 2024; 51: 1-19DOI: 10.1016/j.clp.2023.11.003 AbstractFetal lungs have fewer and smaller arteries with higher pulmonary vascular resistance (PVR) than a

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