Class 1. Persistent Pulmonary Hypertension of the Newborn

Vasopressin in newborns with refractory acute pulmonary hypertension

Simon Ouellet, Christine Drolet, Genevéve Morissette, Annie Pellerin, Audrey HébertCHU de Québec, Université Laval. Canada Pediatric ResearchPediatr Res 2024;DOI: 10.1038/s41390-023-02995-3 AbstractBackground: Acute pulmonary hypertension (aPH) in newborns can be life threatening and challenging to manage. In newborns with refractory aPH, there is currently limited therapeutic agents.Methods: Retrospective single-center cohort study in newborns less than one month old who […]

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Epidemiology of neonatal pneumothorax developed spontaneously and during respiratory supports in neonatal intensive care units

N. Y. Boo, E. L. Lee Ang, The Malaysian National Neonatal RegistryUniversiti Tunku Abdul Rahman. Tengku Ampuan Rahimah Hospital.Malaysia Malaysian Journal of PathologyMalays J Pathol 2023; 45: 441-456DOI: Not Available AbstractBackground: Information on incidence and risk factors associated with different types of neonatal pneumothorax were lacking globally.Objectives: To determine incidences of pneumothorax developed spontaneously and during different

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Maternal treatment with selective serotonin reuptake inhibitors during pregnancy and delayed neonatal adaptation: a population-based cohort study

Marie-Coralie Cornet, Yvonne W. Wu, Heather Forquer, Lyndsay A. Avalos, Achyuth Sriram, Aaron W. Scheffler, Thomas B. Newman, Michael W. KuzniewiczUniversity of California San Francisco. Kaiser Permanente Northern California.United States Archives of Disease in Children Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2023; DOI: 10.1136/archdischild-2023-326049 AbstractObjective: Selective serotonin reuptake inhibitor (SSRI) use is common in

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Shape of Pulmonary Artery Doppler Flow Profile and Right Ventricular Hemodynamics in Neonates

Sébastien Joye, Soume Bhattacharya, Ashraf Kharrat, Bonny Jasani, Regan E. Giesinger, Patrick J. McNamara, Amish JainLausanne University Hospital. LHSC Children’s Hospital. Mount Sinai Hospital and University of Toronto. Hospital of Sick Children. University of Iowa. Switzerland, Canada and United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113864 AbstractObjectives: To characterize pulmonary artery Doppler flow profile (PAFP) patterns

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Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Willem P. de Boode, Afif El-Khuffash, Orla Franklin, Eleanor J. Molloy, Infection, Inflammation, Immunology and Immunisation Section of the European Society for Pediatric Research (ESPR)Children’s Health Ireland at Crumlin. University of California, Davis Children’s Hospital. British Columbia Children’s Hospital. Radboud University Medical Center and Amalia Children’s Hospital. Royal

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Risk factors for death caused by early onset sepsis in neonates: a retrospective cohort study

Xinhong Chen, Huayun He, Hong Wei, Feng Chen, Ya HuChildren’s Hospital of Chongqing Medical University. National Clinical Research Center for Child Health and Disorders. Ministry of Education Key Laboratory of Child Development and Disorders.China BioMed Central Infectious DiseasesBMC Infect Dis 2023; DOI: 10.1186/s12879-023-08851-3 AbstractObjective: To evaluate the association between traditional laboratory findings and death, and to find

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Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study

Enhuan Wei, Xiu-hua Chen, Si-Jia ZhouAffiliated Sanming First Hospital and Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) of Fujian Medical University.China Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1270712 AbstractBackground: This study aims to evaluate the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN).Methods: We conducted a retrospective cohort

Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study Read More »

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

Jamie L. Archambault, Cassidy A. DelaneyUniversity of Colorado.United States BiomedicinesBiomedicines 2023; 11: DOI: 10.3390/biomedicines11113049 AbstractSerotonin (5-HT) is a bioamine that has been implicated in the pathogenesis of pulmonary hypertension (PH). The lung serves as an important site of 5-HT synthesis, uptake, and metabolism with signaling primarily regulated by tryptophan hydroxylase (TPH), the 5-HT transporter (SERT), and

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Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn

Stephanie M. Tsoi, Hythem Nawaytou, Hassan Almeneisi, Martina Steurer, Yili Zhao, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pediatric PulmonologyPediatr Pulmonol 2023; DOI: 10.1002/ppul.26759 AbstractBackground: Neonates with persistent pulmonary hypertension of the newborn (PPHN) can present with hypoxia and right ventricular dysfunction with resultant inadequate oxygen delivery and end-organ damage. This study describes

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Impact of persistent pulmonary hypertension and oxygenation on brain injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia

Keira C. Kilmartin, Asim Al Balushi, Gabriel Altit, Anie Lapointe, Emmanouil Rampakakis, Stephanie Barbosa Vargas, Julie Maluorni, Pia WintermarkMontreal Children’s Hospital and McGill University. National Heart Centre. University of Montreal. Canada and Oman Journal of PerinatologyJ Perinatol 2023; DOI: 10.1038/s41372-023-01805-2 AbstractObjective: To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with

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