Class 1. Persistent Pulmonary Hypertension of the Newborn Archives

Mortality Prediction in Newborns With Persistent Pulmonary Hypertension: A Comparison of Four Illness Severity Scores

Pattima Pakhathirathien, Gunlawadee Maneenil, Anucha Thatrimontrichai, Supaporn Dissaneevate, Manapat PaditaukritPrince of Songkla University.Thailand Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.27484 AbstractObjective: This study aimed to compare the accuracy of four neonatal illness severity scores for predicting mortality in persistent pulmonary hypertension of the newborn (PPHN).Study design: This retrospective study included neonates diagnosed with PPHN between 2013 and 2022. […]

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Fetal-to-Neonatal Transition of an Infant with Transposition of the Great Arteries and Intact Ventricular Septum: A Case Report

Jesse A. Weeda, Arjan B. te Pas, Monique C. Haak, Nico A.Blom, Roel L.F. van der PalenWillem-Alexander Children’s Hospital and Leiden University Medical Centre. Netherlands Biomedicine HubBiomed Hub 2024;DOI: 10.1159/000542723 AbstractIntroduction: Transposition of the great arteries (TGA), especially with intact ventricular septum (TGA-IVS), presents unique challenges during fetal-to-neonatal transition, which can contribute to developing persistent pulmonary hypertension

Fetal-to-Neonatal Transition of an Infant with Transposition of the Great Arteries and Intact Ventricular Septum: A Case Report Read More »

Metagenomic Analysis of Gut Microbiome of Persistent Pulmonary Hypertension of the Newborn

Linli Han, Chuyang Lin, Yue Lan, Yimin Hua, Jinlin Wu, Zhenxin Fan, Yifei LiWest China Second University Hospital and Sichuan University. China Cardiovascular ToxicologyCardiovasc Toxicol 2024; DOI: 10.1007/s12012-024-09949-z AbstractPersistent pulmonary hypertension of the newborn (PPHN) is one of the most common diseases in the neonatal intensive care unit which severely affects neonatal survival. Gut microbes play

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Survival and Risk Factor for Mortality of Infants with Trisomy-21 and Pulmonary Hypertension: A Population-Based Study from a Middle-Income Country

Mohd Nizam Mat Bah, Norazah Zahari, Noor Adibah Abdullah, Mohd Hanafi Sapian, EmieliyuzaYusnita AliasMinistry of Health Malaysia and Hospital Sultanah Aminah. University of Malaya.Malaysia Pediatric CardiologyPediatr Cardiol 2024; DOI: 10.1007/s00246-024-03732-1 AbstractLimited studies are available on the outcome of infants with trisomy-21 and pulmonary hypertension (PHT) in lower- and middle-income countries. This population-based cohort study aims to

Survival and Risk Factor for Mortality of Infants with Trisomy-21 and Pulmonary Hypertension: A Population-Based Study from a Middle-Income Country Read More »

Inhaled Nitric Oxide Treatment of Early Pulmonary Hypertension to Reduce the Risk of Death or Bronchopulmonary Dysplasia in Infants Born Extremely Preterm: A Masked Randomized Controlled Trial

Hussnain Mirza, Jorge Garcia, Matthew Zussman, Rajan Wadhawan, Julie Pepe, William OhAdvent Health for Children.United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114427 AbstractObjective: To determine whether inhaled nitric oxide (iNO) treatment of early pulmonary hypertension (PH) would decrease the risk of death or bronchopulmonary dysplasia (BPD) among infants born extremely preterm.Study design: This was a single-center, masked,

Inhaled Nitric Oxide Treatment of Early Pulmonary Hypertension to Reduce the Risk of Death or Bronchopulmonary Dysplasia in Infants Born Extremely Preterm: A Masked Randomized Controlled Trial Read More »

Management and Follow-Up of a Cohort of Neonates With Meconium Aspiration Syndrome Before and After the Revision of the 2015 Neonatal Resuscitation Program

Inês Silva Costa, Jose Alarcão, Ana Rodrigues Silva, Raquel HenriquesUnidade Local de Saúde (ULS) de Viseu Dão-Lafões. Unidade Local de Saúde (ULS) de Coimbra.Portugal CureusCureus 2024; 16: DOI: 10.7759/cureus.72894 AbstractIntroduction: Meconium aspiration syndrome (MAS) is a respiratory condition associated with high morbimortality. Standards of care changed over the years addressing its specificities, aiming to decrease poor respiratory

Management and Follow-Up of a Cohort of Neonates With Meconium Aspiration Syndrome Before and After the Revision of the 2015 Neonatal Resuscitation Program Read More »

Treprostinil Use in the NICU

Diana LeeUniversity of Pennsylvania School of Nursing.United States Advances in Neonatal CareAdv Neonat Care 2024; 24: 554-560DOI: 10.1097/ANC.0000000000001218 AbstractBackground: Treprostinil is a prostacyclin analogue that is frequently used in the pediatric and adult population to treat pulmonary hypertension; however, it is not often a drug of choice for patients in the neonatal intensive care unit (NICU).Purpose: To evaluate

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Clinical Characteristics and Outcomes of SARS-CoV-2 Infection in Neonates with Persistent Pulmonary Hypertension of the Newborn (PPHN): A Systematic Review

Saad Alhumaid, Muneera Alabdulqader, Zainab Al Alawi, Mohammed A. Al Ghamdi, Mohammed A. Alabdulmuhsin, Hassan I. Al Hassar, Hussain Ahmed Alsouaib, Hussain Ali Alhassan, Hassan Al-Helal, Sameer Ahmed Almoraihel, Mohammed Jaber Alomran, Hassan Redha AL-Tarfi, Abbas Radi Al-Makinah, Tariq T. Alghareeb, Mohammad Abdullah Alkhwaitem, Murtadha Alsuliman, Ali N. Bukhamseen, Khulood Khaled Alajmi, Ahmed Salman Al

Clinical Characteristics and Outcomes of SARS-CoV-2 Infection in Neonates with Persistent Pulmonary Hypertension of the Newborn (PPHN): A Systematic Review Read More »

Experience of patent ductus arteriosus ligation during extracorporeal membrane oxygenation treatment in newborns with severe respiratory failure due to persistent pulmonary hypertension: a single-center retrospective study

Qi-Liang Zhang, Yi-Nan Liu, Ya-Ting Zeng, Yi-Rong Zheng, Qiang ChenFujian Children’s Hospital, Shanghai Children’s Medical Centerand Fujian Medical University.China Italian Journal of PediatricsItal J Pediatr 2024; 50: DOI: 10.1186/s13052-024-01821-8 AbstractBackground: The aim of this study is to summarize our center’s experience with patent ductus arteriosus (PDA) ligation during extracorporeal membrane oxygenation (ECMO) treatment in newborns with severe

Experience of patent ductus arteriosus ligation during extracorporeal membrane oxygenation treatment in newborns with severe respiratory failure due to persistent pulmonary hypertension: a single-center retrospective study Read More »

Genetic burden in neonatal and pediatric-onset pulmonary hypertension: A single-center retrospective study using exome sequencing in a Chinese population

Chen Chen Fucheng Li, Hang Zhou, Dan Wang, Fang Fu, Qiuxia Yu, Ruibin Huang, Yan Lu, You Wang, Guilan Chen, Fei Guo, Tingying Lei, Chunlin Ma, Ru LiGuangzhou Women and Children’s Medical Center. Guangzhou Medical University. China Pediatrics and NeonatologyPediatr Neonatol 2024; DOI: 10.1016/j.pedneo.2024.06.010 AbstractObjective: This single-center retrospective study aimed to investigate the genetic factors contributing to

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