Class 1. Drug-induced and Toxin-induced Pulmonary Hypertension

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model

Duygu Yilmaz Usta, Seval Olgac, Murside Ayse Demirel, Serdar Kula, Cigdem Elmas, Perihan Sezginer, Akif Kavgaci, Zeynep Safak TeksinGazi University. Alanya Alaadin Keykubat University. Turkey European Journal of Pharmaceutics and BiopharmaceuticsEur J Pharma Biopharma 2025; DOI: 10.1016/j.ejpb.2025.114725 AbstractBosentan monohydrate (BOS) is the most preferred molecule for treating the rare pulmonary arterial hypertension (PAH) disease. BOS shows […]

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model Read More »

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension

Bahram Mirani, John D. Dauz, Kana Yazaki, Neda Latifi, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergUniversity of Toronto, Ted Rogers Centre for Heart Research and Hospital for Sick Children. Beth Israel Deaconess Medical Center and Harvard Medical School. University of South Florida.Canada and United States Arteriosclerosis, Thrombosis and Vascular BiologyArterioscler,

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension Read More »

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model

Akash Gupta, Nahla Zaghloul, Senthil Kumar Thulasingam, Ian Richard Robbins, Geetanjali Gupta, Jad Bader, Joe Gn Garcia, Mohamed AhmedUniversity of Arizona. University of Florida. United States Translational ResearchTransl Res 2025; DOI: 10.1016/j.trsl.2025.02.001 AbstractChAT-expressing T cells represent ∼0.01% of total circulating T lymphocytes in adult wild-type mice. However, we previously reported that systemic infusion of ChAT+ve Jurkat

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model Read More »

Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability

Na Li, Zhaoyang Chen, Wenhui Zhang, Yan Li, Xin Huang, Xiao LiFirst Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital. China Journal of Hazardous MaterialsJ Hazard Mater 2025; 489: DOI: 10.1016/j.jhazmat.2025.137575 AbstractRespiratory toxicity of chemicals is a common clinical and environmental health concern. Currently, most in silico prediction models for chemical respiratory

Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability Read More »

TGFBI regulates pulmonary vascular remodeling through endothelial-to-mesenchymal transition in pulmonary arterial hypertension

Da Eun Roh, Na Rae Park, Bo Geum Choi, Youra Kang, Jung-Eun Kim, Yeo Hyang KimKyungpook National University, Kyungpook National University Children’s Hospital and Kyungpook National University Hospital. Republic of Korea Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2025; 751: DOI: 10.1016/j.bbrc.2025.151435 AbstractPulmonary arterial hypertension (PAH) is a progressive disorder characterized by elevated pulmonary artery

TGFBI regulates pulmonary vascular remodeling through endothelial-to-mesenchymal transition in pulmonary arterial hypertension Read More »

Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension in Rats

Ekaterina Legchenko, Philippe Chouvarine, Klea Hysko, Fatimunnisa Qadri, Radoslw Wesolowski, Edgar Specker, Silke Glage, Martin Meier, Katharina Schwarz, Joerg Heineke, Gerhard Pohlmann, Mehmet Ramazanoglu, Michael Bader, Georg HansmannHannover Medical School. Heidelberg University Medical Faculty Mannheim. Max-Delbrück-Center for Molecular Medicine. Leibniz-Forschungsinstitut für Molekulare Pharmakologie. Fraunhofer Institute for Toxicology and Experimental Medicine. Max Delbrück Center for Molecular

Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension in Rats Read More »

Management of Neonatal Hyperinsulinemic Hypoglycemia: Trends Over Nine Years

Sabitha Sasidharan Pillai, Meghan E. Fredette, Joshua Ray Tanzer, Lisa Swartz ToporHasbro Children’s Hospital and Warren Alpert Medical School of Brown University.United States Rhode Island Medical JournalR I Med J 2024; 108: 23-29DOI: Not Available. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/http://www.rimed.org/rimedicaljournal/2025/01/2025-01-23-contribution-pillai.pdf AbstractBackground: With increasing use of diazoxide for hyperinsulinemic hypoglycemia (HH), reporting of serious side effects of diazoxide such as pulmonary

Management of Neonatal Hyperinsulinemic Hypoglycemia: Trends Over Nine Years Read More »

Resolution of Fenfluramine-associated pulmonary arterial hypertension in Lennox-Gastaut syndrome: A case report and literature review

Rebecca Strafella, Richard Wang, Marissa Petchpradub, Ariel Sacknovitz, Patricia E. McGoldrick, Steven M. WolfNew York Medical College and Westchester Medical Center. Boston Children’s Health.United States Epilepsy and Behavior ReportsEpilepsy Behav Rep 2024; 28: DOI: 10.1016/j.ebr.2024.100730 AbstractFenfluramine is a medication originally approved for weight loss before being withdrawn for an association with the development of pulmonary arterial

Resolution of Fenfluramine-associated pulmonary arterial hypertension in Lennox-Gastaut syndrome: A case report and literature review Read More »

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle

Min Li, Brittany Alexandre McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette Riddle, David C. Irwin, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States International Journal of Molecular SciencesInt J Mol Sci 2024; 25: DOI: 10.3390/ijms252111600 AbstractPulmonary hypertension (PH) significantly impairs exercise capacity and the quality of life in patients, which is

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle Read More »

Trends and patterns in pulmonary arterial hypertension-associated hospital admissions among methamphetamine users: a decade-long study

Amanda Husein, Jolie Boullion, Ismail Hossain, Diensn Xing, Tareq Ferdous Khan, Shenuarin Bhuiyan, Gopi K. Kolluru, Mostafizur Rahman Bhuiyan, Nicholas E. Goeders, Steven A. Conrad, John A. Vanchiere A. Wayne Orr, Christopher G. Kevil, Mohammad Alfrad Nobel BhuiyanLouisiana State University Health Sciences Center at Shreveport. Cleveland State University. Bangabandhu Sheikh Mujib Medical University. United States

Trends and patterns in pulmonary arterial hypertension-associated hospital admissions among methamphetamine users: a decade-long study Read More »

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