Class 1. Drug-induced and Toxin-induced Pulmonary Hypertension

From standard to individualized diazoxide therapy in congenital hyperinsulinism: a narrative review

Teresa Wong, Daniel Chan, Cherie Chua, Wenqi Cher, Selina Lim, Suresh Chandran, Fabian YapKK Women’s and Children’s Hospital. Duke NUS Medical School. Singapore Frontiers in PharmacologyFront Pharmacol 2026; 17:DOI: 10.3389/fphar.2026.1781424 AbstractPurpose: Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia in neonates and infants (blood glucose <3.0 mmol/L in first 2-3 days of life; <3.5 mmol/L […]

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Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience

Antonio Gil‑Nagel, Leopoldo Pérez de la Isla, Elena Sanz Pascual, Enrique J. Balbacid Domingo, Juan J. García PeñasRuber Internacional Hospital. San Carlos Clinical Hospital. La Paz Children’s Hospital and La Paz University Hospital. Universidad Europea de Madrid. Spanish Society of Cardiology. Niño Jesús University Children’s Hospital.Spain Neurology and TherapyNeurol Ther 2026; DOI: 10.1007/s40120-026-00930-2 AbstractIntroduction: Fenfluramine (FFA) is

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Lamp Oil Poisoning: Pulmonary Hypertension Following Oil Aspiration Successfully Treated with Inhaled Nitric Oxide

Demet Tosun, Ilyas Bingöl Nihal AkçayIstanbul Kanuni Sultan Suleyman Training and Research Hospital.Turkey Klinische PädiatrieKlin Padiatr 2026; DOI: 10.1055/a-2814-3185 AbstractAbstract Not Available CategoryClass I. Drug-induced and Toxin-induced Pulmonary HypertensionMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free

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Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty-QuintanaMcGovern Medical School University and McWilliams School of Biomedical Informatics of

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response Read More »

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru ZhouNingxia Medical University and General Hospital of Ningxia Medical University.China Drug Design, Development and TherapyDrug Des Dev Ther 2025; 19: 11119-11144DOI: 10.2147/DDDT.S547530 AbstractPurpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH).Methods: 18β-GA-Lips of varying

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension Read More »

Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension

Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils-Bonnet, Martin Wabitsch, Margaret R. MacLeanUniversity of Strathclyde. Queen Mary University of London. Medical University of Vienna. University of Edinburgh. Laval University. Ulm University Medical Center.United Kingdom, Austria, Canada and Germany

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Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs)

Amy Urbina Lopez, Robin T. Varughese, Candice Marti, Aizara Ermekbaeva, Poduri Annapurna, Kothare Sanjeev, Yash ShahTulane University School of Medicine. Cohens Children’s Hospital and Northwell Health. Boston Children’s Hospital. Our Lady of the Lake Children’s Health.United States SeizureSeizure 2025; 133: 161-166DOI: 10.1016/j.seizure.2025.09.013 AbstractIntroduction: Fenfluramine (FFA), an amphetamine derivative, was historically used as an appetite suppressant but was

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs) Read More »

Fenfluramine and Comparative Antiseizure Therapies in Drug-Resistant Epilepsy: A Systematic Review of Efficacy, Cardiometabolic Safety, and Clinical Outcomes

Ashis Pal, Bhavna Singla, Shivam Singla, Muhammad Habib Ur Rehman, Ali Hamza, Ahmad Mohammad, Momina Abid, Aqib ImranDhaka National Medical Institute Hospital. Erie County Medical Center Hospital. TidalHealth Peninsula Regional. King Edward Medical University. Hurley Medical Center. Madinah Teaching Hospital. Nishtar Medical University.Bangladesh, United States and Pakistan CureusCureus 2025; 17: DOI: 10.7759/cureus.91949 AbstractFenfluramine has emerged as

Fenfluramine and Comparative Antiseizure Therapies in Drug-Resistant Epilepsy: A Systematic Review of Efficacy, Cardiometabolic Safety, and Clinical Outcomes Read More »

Final analysis from an open-label extension study of fenfluramine for the treatment of seizures in Lennox-Gastaut syndrome: long-term impact on patients and caregivers

Kelly G. Knupp, Ingrid E. Scheffer, An-Sofie Schoonjansf, Joseph Sullivan, Lieven Lagae, St´ephane Auvin, Elizabeth A. Thiele, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Katherine C. Nickels, Ronald Davis, Michael D. Lock, David Dai, Timothy Minh, Rebecca Zhang Roper, Najla Dickson, Mélanie Langlois, Am´elie Lothe, Antonio Gil-NagelUniversity of Colorado Anschutz Medical Campus. University

Final analysis from an open-label extension study of fenfluramine for the treatment of seizures in Lennox-Gastaut syndrome: long-term impact on patients and caregivers Read More »

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

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