Class 1. Drug-induced and Toxin-induced Pulmonary Hypertension

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru ZhouNingxia Medical University and General Hospital of Ningxia Medical University.China Drug Design, Development and TherapyDrug Des Dev Ther 2025; 19: 11119-11144DOI: 10.2147/DDDT.S547530 AbstractPurpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH).Methods: 18β-GA-Lips of varying […]

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension Read More »

Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension

Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils-Bonnet, Martin Wabitsch, Margaret R. MacLeanUniversity of Strathclyde. Queen Mary University of London. Medical University of Vienna. University of Edinburgh. Laval University. Ulm University Medical Center.United Kingdom, Austria, Canada and Germany

Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension Read More »

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs)

Amy Urbina Lopez, Robin T. Varughese, Candice Marti, Aizara Ermekbaeva, Poduri Annapurna, Kothare Sanjeev, Yash ShahTulane University School of Medicine. Cohens Children’s Hospital and Northwell Health. Boston Children’s Hospital. Our Lady of the Lake Children’s Health.United States SeizureSeizure 2025; 133: 161-166DOI: 10.1016/j.seizure.2025.09.013 AbstractIntroduction: Fenfluramine (FFA), an amphetamine derivative, was historically used as an appetite suppressant but was

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs) Read More »

Fenfluramine and Comparative Antiseizure Therapies in Drug-Resistant Epilepsy: A Systematic Review of Efficacy, Cardiometabolic Safety, and Clinical Outcomes

Ashis Pal, Bhavna Singla, Shivam Singla, Muhammad Habib Ur Rehman, Ali Hamza, Ahmad Mohammad, Momina Abid, Aqib ImranDhaka National Medical Institute Hospital. Erie County Medical Center Hospital. TidalHealth Peninsula Regional. King Edward Medical University. Hurley Medical Center. Madinah Teaching Hospital. Nishtar Medical University.Bangladesh, United States and Pakistan CureusCureus 2025; 17: DOI: 10.7759/cureus.91949 AbstractFenfluramine has emerged as

Fenfluramine and Comparative Antiseizure Therapies in Drug-Resistant Epilepsy: A Systematic Review of Efficacy, Cardiometabolic Safety, and Clinical Outcomes Read More »

Final analysis from an open-label extension study of fenfluramine for the treatment of seizures in Lennox-Gastaut syndrome: long-term impact on patients and caregivers

Kelly G. Knupp, Ingrid E. Scheffer, An-Sofie Schoonjansf, Joseph Sullivan, Lieven Lagae, St´ephane Auvin, Elizabeth A. Thiele, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Katherine C. Nickels, Ronald Davis, Michael D. Lock, David Dai, Timothy Minh, Rebecca Zhang Roper, Najla Dickson, Mélanie Langlois, Am´elie Lothe, Antonio Gil-NagelUniversity of Colorado Anschutz Medical Campus. University

Final analysis from an open-label extension study of fenfluramine for the treatment of seizures in Lennox-Gastaut syndrome: long-term impact on patients and caregivers Read More »

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension Read More »

Pre-existing pulmonary arterial hypertension decompensation associated with e-cigarettes in an adolescent

James Andrew Bishara, Patrick EversOregon Health and Science University and Doernbecher Children’s Hospital.United States Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125100577 AbstractAn adolescent girl with a long-standing history of pulmonary arterial hypertension experienced severe clinical decompensation after starting to use e-cigarettes. A combination of e-cigarette cessation, atrial septostomy, increasing treprostinil, and initiation of sotatercept led

Pre-existing pulmonary arterial hypertension decompensation associated with e-cigarettes in an adolescent Read More »

SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension

Lysanne M. Jorna, Dalibor Nakládal, Johannes N. van Heuveln, Diederik E. van der Feen, Quint A. J. Hagdorn, Guido P. L. Bossers, Annemieke van Oosten, Michel Weij, Ludmila Tkáciková, Sona Tkáciková, Robert H. Henning, Martin C. Harmsen, Rolf M. F. Berger, Guido KrenningUniversity Medical Center Groningen, University of Groningen. Comenius University Bratislava. University of Heidelberg.

SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension Read More »

IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension

Zongye Cai, Ly Tu, Siyu Tian, Lin Deng, Yahong Fu, Carole Phan, Thierry P. P. van den Bosch, Karin Tran‐Lundmark, Bence M. Nagy, Horst Olschewski, Xiaoxuan Li, Sihao Wang, Danan Wang, Yi Yan, Lijun Fu, Karin A. Boomars, Christophe Guignabert, Daphne MerkusSecond Affiliated Hospital and Zhejiang University School of Medicine. Erasmus MC and University Medical Center. Pathophysiologie et Innovation Thérapeutique (HPPIT) and Université Paris-Saclay, School of Medicine. Eighth Affiliated Hospital of Sun Yat-sen University. Lund University and Skane University Hospital. Medical University

IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension Read More »

Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension

Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele MiragoliUniversity of Parma. Deutsches Herzzentrum Der Charité, Campus Virchow-Klinikum. University of Verona. University of Pavia. IRCCS Humanitas Research Hospital. Italy and

Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension Read More »

Scroll to Top