Animal Models of Pulmonary Vascular Disease and Therapy

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and […]

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Animal models of pulmonary arterial hypertension associated with atrial septal defect

Li Wang, Ting Tang, Xiaochun Tian, Chang Peng, Shuqi WuGuizhou Children’s Hospital and Affiliated Hospital of Zunyi Medical University. China Scientific ReportsSci Rep 2024; 14: DOI: 10.1038/s41598-024-69002-5 AbstractPulmonary arterial hypertension (PAH) is a well-known complication of congenital heart disease (CHD). The lack of a satisfactory animal model for PAH associated with CHD (PAH-CHD) has limited progress

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General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V. Kalinichenko,You-Yang Zhao, Michael B. Fallon, Zhiyu DaiUniversity of Arizona. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United States CirculationCirculation 2024; 150: 414-417DOI: 10.1161/CIRCULATIONAHA.123.067981 AbstractAbstract Not Available CategoryVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseAnimal Models of Pulmonary Vascular Disease and TherapyPulmonary Vascular Pathology Age Focus: No

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway Read More »

Lipocalin-2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension

Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang-Ling Yuan, Yingjie Cao, Tsz Kin NgBeijing Children’s Hospital, Capital Medical University and National Center for Children’s Health. Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Children’s Hospital and Capital Medical University. Chinese Academy of

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[Protective effects of 2-methoxyestradiol against hypoxic pulmonary hypertension in neonatal rats]

Ou Xie, Shan-Shan Li, Yang Luo, Le WangFirst Affiliated Hospital of Xinjiang Medical University.China Chinese Journal of Contemporary PediatricsZhongguo Dang Dai Er Ke Za Zhi 2024; 26: 757-764DOI: 10.7499/j.issn.1008-8830.2401078 AbstractObjectives: To investigate the protective effects of 2-methoxyestradiol (2ME) against hypoxic pulmonary hypertension (HPH) in neonatal rats.Methods: Ninety-six Wistar neonatal rats were randomly divided into a normoxia group, a

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Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation

Alban Todesco, Julien Grynblat, Kouamé Kan Firmin Akoumia, Damien Bonnet, Pedro Mendes‐Ferreira, Stéphane Morisset, Denis Chemla, Marilyne Levy, Mathilde Méot, Sophie‐Guiti Malekzadeh‐Milani, Birger Tielemans, Benoit Decante, Carine Vastel‐Amzallag, Paul Habert, Maria‐Rosa Ghigna, Marc Humbert, David Montani, David Boulate, Frédéric PerrosNorth Hospital Aix Marseille University, Assistance Publique-Hôpitaux de Marseille. INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis. Hôpital Necker-Enfants malades AP-HP Université de Paris Cité. Le Kremlin-Bicêtre Université Paris-Saclay. Faculty of Medicine of

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Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M. KUonig, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K. Fleischmann, Daniela WenzelUniversity Hospital of the Ruhr University of Bochum and Ruhr University of Bochum. University Hospital of Nottingham. Massachusetts General Hospital and Harvard Medical School. University of

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension Read More »

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin XiaoUniversity of South China. Affiliated Children’s Hospital of Xiangya School of Medicine. Third Xiangya Hospital. Second Xiangya Hospital. Central South University. Changsha Yali High School. China Journal of Cardiovascular Translational

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Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition

Xinyu Lia, Hui Li, Bo Feng, Xiaoyan Chen, Ting Chen, Jiafei Lu, Huating Xie, Nana Su, Houlin Chen, Chenghao Lou, Runxin Zhuang, Xi Chen, Shengwei Jin, Yu HaoSecond Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Ruijin Hospital and Shanghai Jiao Tong University School of Medicine. China Biomedicine and PharmacotherapyBiomed Pharmacother 2024; DOI: 10.1016/j.biopha.2024.117023

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Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension

Anjira S. Ambade, Mario Naranjo, Tijana Tuhy, Rose Yu, Mery Marimoutou, Allen D. Everett, Larissa A. Shimoda, Stefean L. Zimmerman, Ilton M. Cubero Salazar, Catherine E. Simpson, Ryan J. Tedford, Steven Hsu, Paul M. Hassoun, Rachel L. DamicoJohns Hopkins University. Temple University. Johns Hopkins Community Physicians. Institute for In Vitro Sciences Inc. Medical University of

Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension Read More »

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