Animal Models of Pulmonary Vascular Disease and Therapy

Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage

Andreas Damianos, Shathiyah Kulandavela, Pingping Chen, Patrick Nwajei, Sunil Batlahally, Mayank Sharma, Silvia Alvarez-Cubela, Juan Dominguez-Bendala, Ronald Zambrano, Jian Huang, Joshua M. Hare, Augusto Schmidt, Merline Benny, Nelson Claure, Karen YoungUniversity of Miami Miller School of Medicine.United States Journal of Applied PhysiologyJ Appl Physiol 2022; 133: 1031-1041DOI: 10.1152/japplphysiol.00708.2021 AbstractAdults born preterm have an increased risk of […]

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Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

Ruaa Al-Qazaz, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins,Stephen L. ArcherQueen’s University. University of Minnesota Medical School. Laval University. University of Strathclyde.Canada, United States

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Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development

Quinn A. Bonafiglia, Yu-Qing Zhou, Guangpei Hou, Rhidita Saha, Ying-Han R. Hsu, Jonah Burke-Kleinman, Michelle P. BendeckUniversity of Toronto, Ted Rogers Centre for Heart Research and University Health Network.Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2022; 67: 562-573DOI: 10.1165/rcmb.2022-0124OC AbstractPulmonary hypertension (PH) is a multifaceted condition characterized by elevated

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Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension

Mayank Sharma, Michael A. Bellio, Merline Benny, Shathiyah Kulandavelu, Pingping Chen, Chawisa Janjindamai, Chenxu Han, Liming Chang, Shanique Sterling, Kevin Williams, Andreas Damianos, Sunil Batlahally, Kaitlyn Kelly, Daniela Aguilar-Caballero, Ronald Zambrano, Shaoyi Chen, Jian Huang, Shu Wu, Joshua M. Hare, Augusto Schmidt, Aisha Khan, Karen YoungUniversity of Miami Miller School of Medicine.United States Stem Cells Translational Medicine Stem Cells Transl Med 2022; 11: 828-840DOI: 10.1093/stcltm/szac041 AbstractMesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary

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Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life

Hironori Oshita, Hirofumi Sawada, Yoshihide Mitani, Naoki Tsuboya, Jane C. Kabwe, Junko Maruyama, Ali yusuf, Hiromasa Ito, Ryuji Okamoto, Shoichiro Otsuki, Noriko Yodoya, Hiroyuki Ohashi, Kazunobu Oya, Yuhko Kobayashi, Issei Kobayashi, Kaoru Dohi, Yuhei Nishimura, Shinji Saitoh, Kazuo Maruyama, Masahiro HirayamaMie University Graduate School of Medicine. Nagoya City University Graduate School of Medical Sciences. Suzuka

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Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Danielle S. Roberts, Laura G. Sherlock, Janelle N. Posey, Jamie L. Archambault, Eva S. Nozik, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus.United States Physiological ReportsPhysiol Rep 2022; 10: DOI: 10.14814/phy2.15482 AbstractSerotonin (5-hydroxytryptamine, 5-HT) is a potent pulmonary vasoconstrictor and contributes to high pulmonary vascular resistance in the developing ovine lung. In experimental pulmonary hypertension (PH), pulmonary expression of tryptophan hydroxylase-1 (TPH1),

Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension Read More »

Upregulated TSP1 and CD47 Expression in the Lung in Nitrofen-induced Congenital Diaphragmatic Hernia

Hajime TakayasuKitasato University. University of Tsukuba.Japan Pediatrics InternationalPediatr Int 2022; DOI: 10.1111/ped.15447 AbstractBackground: Persistent pulmonary hypertension remains a major cause of mortality and morbidity in congenital diaphragmatic hernia (CDH). The secreted glycoprotein thrombospondin-1 (TSP1), a ligand for receptor CD47, is widely expressed on both systemic and pulmonary vascular cells. TSP1-CD47 signaling has been reported to be one

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Targeted treprostinil delivery inhibits pulmonary arterial remodeling

Aijun Liu, Bin Li, Ming Yang, Yongying Shi, Junwu SuBeijing Anzhen Hospital. The First Affiliated Hospital of Guangzhou Medical University. China European Journal of PharmacologyEur J Pharmacol 2022; 923: DOI: 10.1016/j.ejphar.2021.174700 AbstractIntroduction: Pulmonary arterial hypertension (PAH) is a fatal disease caused by the progressive remodeling of pulmonary arteries (PAs). Treprostinil (TPS) is a tricyclic benzidine prostacyclin clinically

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Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC

Wanjie Huang, Na Liu, Xin Tong, Yanna DuShengjing Hospital of China Medical University. The First Affiliated Hospital of Zhengzhou University.China International Journal of Molecular MedicineInt J Mol Med 2022; 49: DOI: 10.3892/ijmm.2021.5074 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC Read More »

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

Zongye Cai, Siyu Tian, Theo Klein, Ly Tu, Laurie W. Geenen, Thomas Koudstaal, Annemien E. van den Bosch, Yolanda B. de Rijke, Irwin K. M. Reiss, Eric Boersma, Claude van der Ley, Martijn Van Faassen, Ido Kema, Dirk J. Duncker, Karin A. Boomars, Karin Tran‑Lundmark, Christophe Guignabert, Daphne MerkusErasmus MC University Medical Center. Zhejiang University

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