Animal Models of Pulmonary Vascular Disease and Therapy

Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo

Takeshi Furukawa, Masahiko Kishiro, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Katsumi Akimoto, Toshiaki Shimizu, Shiori Kawasaki, Toshio KumasakaJuntendo University School of Medicine.Japan Pediatric CardiologyPediatr Cardiol 2010; 31: 773-779DOI: 10.1007/s00246-010-9695-8 AbstractThe outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness remains […]

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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis

Jiaquan Zhu, HarukiIde, Yaqin Yana Fu, Anouk-Martine Teichert, Hideyuki Kato, Richard D. Weisel, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneThe Hospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2014; 148: 2550-2557DOI: 10.1016/j.jtcvs.2014.07.050 AbstractObjectives: Pulmonary vein stenosis (PVS) is a relentless disease with

Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis Read More »

Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins

Hideyuki Kato, Yaqin Yana Fu, Jiaquan Zhu, Shabana Aafaqi, Otto Rahkonen, Cameron Slorach, Alexandra Traister, Chung Ho Leung, David Chiasson, Luc Mertens, Lee Benson, Richard D. Weisel, Boris Hinz, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneHospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ

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Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats

Yoshitaka Fujimoto, Takashi Urashima, Fumie Kawachi, Toru Akaike, Yoichiro Kusakari, Hiroyuki Ida, Susumu MinamisawaJikei University School of Medicine.Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovas Surg 2017; 154: 1742-1753DOI: 10.1016/j.jtcvs.2017.06.053 AbstractObjective: A rat model of left atrial stenosis-associated pulmonary hypertension due to left heart diseases was prepared to elucidate its mechanism.Methods: Five-week-old Sprague-Dawley rats were randomly divided

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Lymphatic Endothelial Cell Defects in Congenital Cardiac Patients With Postoperative Chylothorax

Aqsa Shakoor, June K. Wu, Ajit Muley, Christopher Kitajewski, Joseph D. McCarron, Noa Shapiro-Franklin, Rozelle Corda, Sophia Chrisomalis-Dringe, Paul J. Chai, Carrie J. ShawberColumbia University Irving Medical Center Vagelos College of Physicians & Surgeons and New York Presbyterian Hospital/Morgan Stanley Children’s Hospital.United States Journal of Vascular AnomaliesJ Vasc Anol 2021; 2: DOI: 10.1097/jova.0000000000000016 AbstractObjectives: Chylothorax following cardiac

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Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing WuShenzhen People’s Hospital, The Second Clinical Medical College of Jinan University and First Affiliated Hospital of Southern University of Science and Technology. Longgang ENT Hospital.University of Chinese Academy of Science-Shenzhen Hospital.China Journal of Bioenergetics and BiomembranesJ Bioenerg Biomembr 2021; 53: 13-23DOI: 10.1007/s10863-020-09863-3 AbstractBronchopulmonary dysplasia (BPD)

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A Read More »

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions

Evan M. Zahn, Eason Abbott, Neil Tailor, Shyam Sathanandam, Dustin ArmerCedars Sinai Medical Center. Renata Medical Company. Morgan Stanley Children’s Hospital. LeBonheur Children’s Hospital.United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2021; 98: 117-127DOI: 10.1002/ccd.29706 AbstractObjectives: This study sought to obtain in vivo data on a new stent and delivery system specifically designed for implantation in infants

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions Read More »

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine Read More »

Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model

Ryan J. Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. Francois, Luke Lamers, Alejandro Roldán‑AlzateUniversity of Wisconsin-Madison.United States Journal of Cardiovascular Magnetic ResonanceJ Cardiovasc Magn Reson 2021; 13: DOI: 10.1186/s12968-021-00709-4 AbstractBackground: Branch pulmonary artery (PA) stenosis (PAS) commonly occurs in patients with congenital heart disease (CHD). Prior studies have documented technical success and clinical

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Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin. United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 1477-1492DOI: 10.1007/s10439-020-02696-6 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the pulmonary arteries (PAs) remodel their lumen diameter to maintain constant wall shear stress (WSS).

Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions Read More »

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