Animal Models of Pulmonary Vascular Disease and Therapy

Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation

Yanan Zhang, Xiaoyu Tiana, Liangyi Chenb, Shiqun Zhaob, Xinjing Tang, Xin Liu, Dan Zhou, Chaoshu Tang, Bin Geng, Junbao Dua, Hongfang Jina, Yaqian HuangPeking University First Hospital and Peking University. Wuhan Children’s Hospital. Fuwai Hospital and Peking Union Medical College. China Redox BiologyRedox Biol 2025; 80: DOI: 10.1016/j.redox.2025.103493 AbstractBackground: The binding of endothelin-1 (ET-1) to endothelin type […]

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Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential

Fabian Doktor, Lina Antounians, Rebeca Lopes Figueira, Kasra Khalaj, Miriam Duci, Augusto ZaniHospital for Sick Children and University of Toronto. Leipzig University.Canada and Germany Stem Cells Translational MedicineStem Cells Transl Med 2025; 14: DOI: 10.1093/stcltm/szae095 AbstractDisruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic

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Endothelial Cpt1a Inhibits Neonatal Hyperoxia-Induced Pulmonary Vascular Remodeling by Repressing Endothelial-Mesenchymal Transition

Xiaoyun Li, Katy Hegarty, Fanjie Lin, Jason L. Chang, Amro Abdalla, Karthik Dhanabalan, Sergey O. Solomevich, Wenliang Song, Karim Roder, Chenrui Yao, Wenju Lu, Peter Carmeliet, Gaurav Choudhary, Phyllis A. Dennery, and Hongwei YaoBrown University. Providence VA Medical Center. Warren Alpert Medical School of Brown University. Jinan University. First Affiliated Hospital of Guangzhou Medical University.

Endothelial Cpt1a Inhibits Neonatal Hyperoxia-Induced Pulmonary Vascular Remodeling by Repressing Endothelial-Mesenchymal Transition Read More »

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Tsutomo Shinohara, Jan-Ranier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Divya Guntur, Shalina Taylor, Sarasa Isobe, Melody Dong, Weiguang Yang, Katherine Guo, Benjamin D. Franco, Cholawat Pacharinsak, Laura J. Pisani, Shinji Saitoh, Yoshihide Mitani, Alison L. Marsden, Jesse M. Engreitz, Jakob Körbelin, Marlene RabinovitchLucile

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LPS Increases Artery but Not Airway Contraction in Precision Cut Lung Slices from a Mouse Model of ARDS

Emma Lamanna, Zoe F. Kropf, Raymond Luong, Matthew Narayan, Elizabeth A. Richards, Bailey Cardwell, Simon G. Royce, Claudia A. Nold-Petry, Jane E. BourkeMonash University. RMIT University. Royal Melbourne Institute of Technology. Hudson Institute of Medical Research.Australia American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2024; DOI: 10.1165/rcmb.2024-0249OC AbstractAcute respiratory distress syndrome

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Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension

Run Lan, Meng-Jie Zhang, Ke Liu, Fang-Fang Meng, Xiao-He Xu, Chen-Chen Wang, Meng-Qi Zhang, Yi Yan, Jie-Jian Kou, Lu-Ling Zhao, Yang-Yang He, Hong-Da ZhangHuaihe Hospital and Henan University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital, National Center for Cardiovascular Diseases and Chinese Academy of

Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension Read More »

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle

Min Li, Brittany Alexandre McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette Riddle, David C. Irwin, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States International Journal of Molecular SciencesInt J Mol Sci 2024; 25: DOI: 10.3390/ijms252111600 AbstractPulmonary hypertension (PH) significantly impairs exercise capacity and the quality of life in patients, which is

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle Read More »

THBS1 mediates hypoxia driven EndMT in pulmonary hypertension

Bingming Peng, Yingzhen Zhou, Xingmeng Fu, Li Chen, Zhengxia Pan, Qijian Yi, Tengteng Zhao, Zhou Fu, Ting WangChildren’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders and Ministry of Education Key Laboratory of Child Development and Disorders. University of California, San Diego.China and United States Pulmonary CirculationPulm Circ 2024;

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T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension

Cheng Li, Pingping Liu, Hao Zhu, Huan Yang, Jun Zha, Huiling Yao, Shaoze Zhang, Jin Huang, Guang Li, Gang Jiang, Yongliang Jiang, Aiguo DaiHunan Provincial People’s Hospital and First Affiliated Hospital of Hunan Normal University. Hunan Children’s Hospital. Changsha Central Hospital and University of South China. Hunan University of Chinese Medicine. China Respiratory ResearchRespir Res

T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension Read More »

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

Sajeth Dinakaran, Sima Qutaina, Haitian Zhao, Yuefeng Tang, Zhimin Wang, Santiago Ruiz, Aya Nomura-Kitabayashi, Christine N. Metz, Helen M. Arthur, Stryder M. Meadows, Lionel Blanc, Marie E. Faughnan, Philippe MarambaudFeinstein Institutes for Medical Research and Northwell Health. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Institut Pasteur de Montevideo. Newcastle University. Tulane University. Cohen

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia Read More »

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