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Navigating Pediatric Cor Pulmonale: A Comprehensive Review of Diagnosis and Management

Yash Thakur, Revat J. Meshram, Amar TaksandeJawaharlal Nehru Medical College and Datta Meghe Institute of Higher Education and Research.India CureusCureus 2024; 16: DOI: 10.7759/cureus.67782 AbstractPediatric cor pulmonale, characterized by right ventricular dysfunction due to chronic pulmonary hypertension, presents significant diagnostic and management challenges. This comprehensive review delves into this complex condition’s etiology, clinical presentation, diagnostic strategies,

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GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control

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Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease

Yanming Shen, Dongshan Liao, Wenlin Shangguan, Liangwan ChenFujian Medical University. Union Hospital. Fuzhou Changle District People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2024; DOI: 10.3389/fcvm.2024.1424679 AbstractObjective: This study strives to the variation and significance of microRNA-21 (miR-21) in children with congenital heart disease (CHD)-related pulmonary artery hypertension (PAH).Methods: Children with CHD (n = 179) were selected as subjects,

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Impact of general anesthesia on the echocardiographic assessment of right ventricular function in pediatric patients with pulmonary arterial hypertension

Charles T. Simpkin, Billy J. McElroy, Gareth J. Morgan, David Dunbar Ivy, Dale A. Burkett, Mark D. Twite, Benjamin S. FrankUniversity of Colorado Denver. United States Pulmonary CirculationPulm Circ 2024; DOI: 10.1002/pul2.12435 AbstractOne of the great diagnostic challenges for children with pulmonary arterial hypertension is the need for general anesthesia (GA) to enable successful right heart

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Association between pertactin-producing Bordetella pertussis and fulminant pertussis in infants: a multicenter study in France, 2008-2019

Pauline Leroux, Soraya Matczak, Valérie Bouchez, Stevenn Volant, Antoine Ouziel, Elise Launay, Albert Faye, Valérie Rabier, Jean Sarlangue, Eric Jeziorski, Zoha Maakaroun-Vermesse, Fouad Madhi, Didier Pinquier, Mathie Lorrot, Marie Pouletty, Aymeric Cantais, Etienne Javouhey, Fatima Aït Belghiti, Sophie Guillot, Carla Rodrigues, Sylvain Brisse, Jérémie F. Cohen, Julie ToubianaUniversité Paris Cité. Hospices Civils de Lyon. University

Association between pertactin-producing Bordetella pertussis and fulminant pertussis in infants: a multicenter study in France, 2008-2019 Read More »

Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension

Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Valerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Grünig, Grzegorz Kopeć, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Yayun Xu, Barry Miller, Marcie Fowler, John Butler, Jeorg Koglin, Janethe de Oliveira Pena, and Marc Humbert, for

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Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH)

Eva Petrow, Changyong Feng, Ashley Frazer-Abel, Roberta Goncalves Marangoni, Katie Lutz, William C. Nichols, V. Michael Holers, Christopher Ritchlin, R. James White III, Benjamin D. KormanUniversity of Rochester Medical Center. University of Colorado School of Medicine. Cincinnati Children’s Medical Center and University of Cincinnati College of Medicine. United States Seminars in Arthritis and RheumatismSemin Arthritis

Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) Read More »

Clinical profile and thiamine transporter gene (SLC19A2 and SLC19A3) variations in infants with thiamine-responsive pulmonary hypertension and acute respiratory infection

Swathi Shenoy, Vijaya Kumar Deekshit, Swathi Sunil Rao, Prathibha Shankar Ashwini, Rathika Damodara ShenoyNITTE University Center for Science Education and Research. Doctor’s Hospital. American University of Antigua College of Medicine.India, Antigua and Barbuda Journal of Tropical PediatricsJ Trop Pediatr 2024; DOI: 10.1093/tropej/fmae030 AbstractMaternal thiamine deficiency is prevalent in low- and middle-income countries. Thiamine-responsive pulmonary hypertension (TRPHTN)

Clinical profile and thiamine transporter gene (SLC19A2 and SLC19A3) variations in infants with thiamine-responsive pulmonary hypertension and acute respiratory infection Read More »