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Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism

Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James WestVanderbilt University Medical Center. Second Xiangya Hospital of Central South University. Wistar Institute.United States and China Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70054 AbstractFemale sex increases risk of Group I pulmonary arterial hypertension by […]

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Screening For Critical Congenital Heart Disease Using Pulse-Oximetry, The First Egyptian Multicentre Study

Mohammad Eltahlawi, Alaa Elghamrawy, Maiy Hamdy Elsayed, Mona Hafez, Asmaa Elmesiry, Mohamed Bayomy, Hani Adel, Mahmoud Elfayoumy, Sahbaa Hafez, Said Morsy, Mahmoud Elhady, Baher Nashy, Mohamed Abo ElelaZagazig University. Ministry of Health. Ain Shams University. Mansoura University. Tanta University. Alazhar University. Alexandria University. Benha University. Assuit University.Egypt Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125000289 AbstractBackground: Congenital

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Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability

Na Li, Zhaoyang Chen, Wenhui Zhang, Yan Li, Xin Huang, Xiao LiFirst Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital. China Journal of Hazardous MaterialsJ Hazard Mater 2025; 489: DOI: 10.1016/j.jhazmat.2025.137575 AbstractRespiratory toxicity of chemicals is a common clinical and environmental health concern. Currently, most in silico prediction models for chemical respiratory

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An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension

Ram Raj Prasad, Sushil Kumar, Hui Zhang, Min Li, Cheng-Jun Hu, Suzette Riddle, Brittany A. McKeon, M.G. Frid, Konrad Hoetzenecker, Slaven Crnkovic, Grazyna Kwapiszewska, Rubin M. Tuder, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus. Medical University of Vienna. Medical University of Graz.United States and Austria Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.184141 AbstractThe

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Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series

Aster De Vadder, Lotte Lemloh, Bartolomeo Bo, Lennart Hale, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Germany and United Kingdom European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06019-6 AbstractCongenital diaphragmatic hernia (CDH)-associated pulmonary hypertension (PH) is associated with high morbidity and mortality. Pulmonary vasodilative management is challenging

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Modifiable and Non-Modifiable Risk Factors for Tracheostomy in Preterm Infants

Brandon Dudeck, Elias W. Abebe, Wendy Sun, Peter R. Gaskin, Rose M. Viscardi, Eunsung ChoUniversity of Maryland School of Medicine. Wellspan York Hospital. Los Angeles Mattel Children’s Hospital and University of California, Los Angeles.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71005 AbstractObjective: To identify risk factors for tracheostomy among infants born < 33 week gestational age.Methods: We

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Risk Factors Associated With the Development of Late Pulmonary Artery Hypertension in Extremely Premature Infants

Paige E. Condit, JohnS. Hokanson Vivek Balasubramaniam, David J. McCulley, Michael Lasarev, Luke Lamers, Ryan M. McAdams, Dinushan C. KaluarachchiUniversity of Wisconsin School of Medicine and Public Health. University of California, San Diego. United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.27501 AbstractObjective: To identify risk factors for late pulmonary artery hypertension (PH) at 36 weeks’ postmenstrual

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Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

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Severe pulmonary hypertension in a small-for-date neonate with skeletal dysplasia

Khuloud Mohamed, Mohammad A. A. Bayoumi, Muhammed Riyas Rahmath, Einas Elzubier ElmalikHamad Medical CorporationQatar British Medical Journals Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2024-264256 AbstractAbstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Lung Hypoplasia Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication Article Access

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Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score

Vladimir L. Cousin, Caroline Caula, Jason Vignot, Raphael Joye, Matthieu Blanc, Clémence Marais, Pierre TissièresAP-HP Paris Saclay University, Bicêtre Hospital. Evelina London Children’s Hospital. Geneva University Hospital. Hospital for Sick Children and University of Toronto. France, United Kingdom, Switzerland and Canada Critical CareCrit Care 2025; 29: DOI: 10.1186/s13054-025-05300-2 AbstractBackground: Despite widespread vaccination programs, pertussis continues circulating within

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